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  4. Human Ribonuclease 7(RNASE7) ELISA kit

Human Ribonuclease 7(RNASE7) ELISA kit

  • 中文名稱：
    人核糖核酸酶7(RNASE7)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL019798HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人核糖核酸酶7(RNASE7)酶聯(lián)免疫試劑盒（CSB-EL019798HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、尿液、唾液、組織培養(yǎng)上清液、組織勻漿、細胞裂解物樣本中的RNASE7含量。RNASE7是具有研究價值的靶點。它在人體的免疫防御等方面可能發(fā)揮重要作用。相關(guān)研究機制主要圍繞其對病原體的作用展開，如它可能通過降解病原體的核酸來抑制其活性，進而抵御感染，后續(xù)還需更多研究深入明晰其作用細節(jié)。試劑盒檢測范圍為1.56 ng/mL-100 ng/mL，適用于體外研究RNASE7在感染性疾病機制、上皮免疫調(diào)控或黏膜屏障功能等領(lǐng)域的表達規(guī)律，例如分析不同病理狀態(tài)下唾液或尿液中RNASE7的動態(tài)變化，或評估體外培養(yǎng)細胞受病原體刺激后的分泌水平，為探索其在先天免疫中的功能提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    EC 3.1.27.- ELISA Kit; MGC133220 ELISA Kit; Ribonuclease 7 ELISA Kit; ribonuclease, RNase A family, 7 ELISA Kit; RNAS7_HUMAN ELISA Kit; RNase 7 ELISA Kit; RNASE7 ELISA Kit; SAP 2 ELISA Kit; SAP-2 ELISA Kit; Skin derived antimicrobial protein 2 ELISA Kit; Skin-derived antimicrobial protein 2 ELISA Kit
  • 縮寫：
    RNASE7
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, urine, saliva, cell culture supernates, tissue homogenates, cell lysates
  • 檢測范圍：
    1.56 ng/mL-100 ng/mL
  • 靈敏度：
    0.39 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Epigenetics and Nuclear Signaling
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human RNASE7 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %100
    Range %95-105
    1:2Average %98
    Range %93-103
    1:4Average %89
    Range %80-95
    1:8Average %88
    Range %82-99
  • 回收率：
    The recovery of human RNASE7 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 10095-105
    EDTA plasma (n=4)104100-109
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    1002.410 2.456 2.433 2.256
    501.618 1.629 1.624 1.447
    251.076 1.098 1.087 0.910
    12.50.726 0.703 0.715 0.538
    6.250.490 0.483 0.487 0.310
    3.120.384 0.354 0.369 0.192
    1.560.269 0.282 0.276 0.099
    00.178 0.176 0.177 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Causes loss of bacterial membrane integrity. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity.
  • 基因功能參考文獻：
    1. These data suggest that the induction of RNase 7 in response to Mycobacterium tuberculosis could have a role in anti-mycobacterial immunity. PMID: 29346642
    2. RNase 7 has immunomodulatory functions on TH2 cells and decreases the production of TH2 cytokines in the skin. PMID: 28378334
    3. Our results indicate that RNase 7 is an important factor released by keratinocytes to control the growth of P. aeruginosa on the skin surface. PMID: 27513608
    4. Insulin and PI3K/AKT signaling are essential for RNase 7 expression and increased infection risks in diabetic patients may be secondary to suppressed RNase 7 production. PMID: 27401534
    5. This article provides an overview about the role of RNase 7 in cutaneous defense with focus on the molecular mechanism of the antimicrobial activity of RNase 7, the regulation of RNase 7 expression, and the role of RNase 7 in skin diseases. [review] PMID: 27089327
    6. RNH1 bound to RNase 7 and suppressed its antimicrobial activity by blocking its ability to bind the cell wall of uropathogenic bacteria. PMID: 24107847
    7. RNase 7 is an antimicrobial protein that plays an important role in the innate immune defense system of human epithelia. PMID: 12244054
    8. Suggest that RNase 7 may function as antimicrobial peptide with a role in the differentiation and development of the primitive epidermis. PMID: 23545750
    9. the influence of STAT3 on the IL-17A/IFN-gamma -mediated RNase 7 induction PMID: 23555696
    10. RNase 7 expression is increased in the urinary tract with infection and has antibacterial activity against uropathogens at micromolar concentrations. PMID: 23302724
    11. a complex relationship between tear induction of miR-762, its modulation of innate defense genes, and P. aeruginosa internalization PMID: 23469087
    12. RNASE7 prevents staphylococcal skin infections PMID: 20668470
    13. proteases contribute indirectly to the defense function of the stratum corneum by releasing the RNase inhibitor mediated inhibition of RNase 5 and RNase 7. PMID: 19262607
    14. Using phospholipid vesicles as membrane models, RNase 3 triggers first the vesicle aggregation, while RNase 7 induces leakage well before the aggregation step. PMID: 19366593
    15. data indicate that RNase 7 contributes to the E. faecium-killing activity of skin extracts and suggest an important role for RNase 7 in the protection of human skin against E. faecium colonization PMID: 19641608
    16. These findings suggest that antimicrobial peptides found at high baseline levels in healthy skin, such as RNase 7, confer protection against Staphylococcus aureus infection of the skin. PMID: 19919305

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Pancreatic ribonuclease family
  • 組織特異性：
    Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level). Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut. Expressed in liver, kidney
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19278

    OMIM: 612484

    KEGG: hsa:84659

    STRING: 9606.ENSP00000298690

    UniGene: Hs.525206



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