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  4. Recombinant Human Rho guanine nucleotide exchange factor 10 (ARHGEF10), partial

Recombinant Human Rho guanine nucleotide exchange factor 10 (ARHGEF10), partial

  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 10(ARHGEF10) ,partial
  • 貨號：
    CSB-YP002041HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 10(ARHGEF10) ,partial
  • 貨號：
    CSB-EP002041HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 10(ARHGEF10) ,partial
  • 貨號：
    CSB-EP002041HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 10(ARHGEF10) ,partial
  • 貨號：
    CSB-BP002041HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 10(ARHGEF10) ,partial
  • 貨號：
    CSB-MP002041HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ARHGEF10
  • Uniprot No.：
  • 別名：
    ARHGA_HUMAN; ARHGEF10; DKFZp686H0726; GEF10; KIAA0294; MGC131664; Rho guanine nucleotide exchange factor (GEF) 10; Rho guanine nucleotide exchange factor 10
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    May play a role in developmental myelination of peripheral nerves.
  • 基因功能參考文獻：
    1. Ectopic expression of an N-terminal-truncated ARHGEF10 mutant led to the generation of large vesicle-like structures containing both Rab6 and Rab8. PMID: 27550519
    2. This study provided new insights into the roles of ARHGEF10 SNPs rs2280887, rs9657362, and rs4480162 in the development and progression of ischemic stroke in northern Chinese Han population. PMID: 27934548
    3. A significant association of ARHGEF10 with paclitaxel chemotherapy induced peripheral neuropathy was found. PMID: 26143528
    4. Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10). PMID: 21719701
    5. the rs4376531 polymorphism in the ARHGEF10 gene is a risk factor for atherothrombotic stroke in the Han Chinese population PMID: 21743172
    6. The functional single-nucleotide polymorphism of ARHGEF10 confers the susceptibility to atherothrombotic stroke. PMID: 20042462
    7. data support a role for ARHGEF10 in developmental myelination of peripheral nerves PMID: 14508709
    8. Gef10 is the third member of a Rho-specific GEF family with unusual protein architecture PMID: 16896804
    9. A novel RhoA-dependent signaling pathway under the control of ARHGEF10 has a pivotal role in the regulation of the cell division cycle. PMID: 19635168

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  • 相關(guān)疾病：
    Slowed nerve conduction velocity (SNCV)
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14103

    OMIM: 608136

    KEGG: hsa:9639

    STRING: 9606.ENSP00000340297

    UniGene: Hs.98594



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