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  4. Recombinant Human Rho GTPase-activating protein 26 (ARHGAP26), partial

Recombinant Human Rho GTPase-activating protein 26 (ARHGAP26), partial

  • 中文名稱：
    Recombinant Human Rho GTPase-activating protein 26(ARHGAP26) ,partial
  • 貨號：
    CSB-YP892479HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Rho GTPase-activating protein 26(ARHGAP26) ,partial
  • 貨號：
    CSB-EP892479HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Rho GTPase-activating protein 26(ARHGAP26) ,partial
  • 貨號：
    CSB-EP892479HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Rho GTPase-activating protein 26(ARHGAP26) ,partial
  • 貨號：
    CSB-BP892479HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Rho GTPase-activating protein 26(ARHGAP26) ,partial
  • 貨號：
    CSB-MP892479HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ARHGAP26
  • Uniprot No.：
  • 別名：
    arhgap26; FLJ42530; GRAF; GRAF1; GTPase regulator associated with focal adhesion kinase; GTPase regulator associated with focal adhesion kinase pp125(FAK) ; KIAA0621; oligophrenin 1 like protein; Oligophrenin-1-like protein; oligophrenin1like protein; OPHN1L; OPHN1L1; RHG26_HUMAN; Rho GTPase activating protein 26 ; Rho GTPase activating protein26; Rho GTPase-activating protein 26; Rho-type GTPase-activating protein 26
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    GTPase-activating protein for RHOA and CDC42.
  • 基因功能參考文獻：
    1. GRAF1 plays a role in the maintenance of normal epithelial phenotype and its depletion leads to an epithelial-mesenchymal transition-like process that might be involved in neoplastic transformation. PMID: 27588930
    2. We conclude that a transient interaction between Cdc42 and GRAF1 drives endocytic turnover and controls the transition essential for endosomal maturation of plasma membrane internalised by this mechanism. PMID: 26446261
    3. GRAF expression is a favorable prognostic marker in patients with acute myeloid leukemia. PMID: 25088035
    4. ADAR1 regulates the expression of ARHGAP26 through A-to-I RNA editing by disrupting the binding of miR-30b-3p and miR-573 within the 3' UTR of ARHGAP26. PMID: 24067935
    5. proposed that GRAF1 remodels membrane microdomains at adhesion sites into endocytic carriers, facilitating membrane turnover during cell morphological changes PMID: 21965292
    6. Findings suggest that the hypermethylation of GRAF promoter might be one of early events in the development of AML. PMID: 21074269
    7. a GTPase-activating protein that regulates muscle maturation and to highlight the functional importance of BAR domains in myotube formation PMID: 21622574
    8. Decreased level of GRAF transcript is associated with acute myeloid leukemia, myelodysplastic syndrome and chronic myeloid leukemia. PMID: 20704716
    9. The GRAF gene was down-regulated in AML, which might play a role in the leukemogenesis. PMID: 20533268
    10. The analysis of the expression pattern of the GRAF1/OPHN-1-L gene in human tissues and organs revealed the predominant brain expression of a novel splicing isoform. PMID: 20602808
    11. abnormal GRAF methylation might be an adverse prognostic event in MDS PMID: 20374274
    12. Graf residues important for the structural integrity are critical for binding RhoA and for the catalytic activity of GAP, but GTPase selectivity appears to be modulated by a more subtle interplay involving residues on the periphery of the main interface. PMID: 18929667
    13. GRAF is a negative regulator of RhoA in vivo, it acts as a GTP-ase activating protein (GAP) for RhoA and may be a downstream effector of RhoA in certain cell types. PMID: 9858476

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  • 相關(guān)疾?。?/div>
    Leukemia, juvenile myelomonocytic (JMML)
  • 亞細胞定位：
    Cell junction, focal adhesion. Cytoplasm, cytoskeleton.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17073

    OMIM: 605370

    KEGG: hsa:23092

    STRING: 9606.ENSP00000274498

    UniGene: Hs.654668



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