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  4. Recombinant Human Required for meiotic nuclear division protein 1 homolog (RMND1)

Recombinant Human Required for meiotic nuclear division protein 1 homolog (RMND1)

  • 中文名稱：
    人RMND1重組蛋白
  • 貨號：
    CSB-YP882123HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RMND1重組蛋白
  • 貨號：
    CSB-EP882123HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RMND1重組蛋白
  • 貨號：
    CSB-EP882123HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RMND1重組蛋白
  • 貨號：
    CSB-BP882123HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RMND1重組蛋白
  • 貨號：
    CSB-MP882123HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RMND1
  • Uniprot No.：
  • 別名：
    bA351K16; bA351K16.3; C6orf96; chromosome 6 open reading frame 96; FLJ20627; MGC117362; MGC149570; MGC882602; required for meiotic nuclear division 1 homolog (S. cerevisiae); Required for meiotic nuclear division protein 1 homolog; Rmnd1; RMND1_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    13-449
  • 氨基酸序列
    HHILSKAH QCRRIGHLML KPLKEFENTT CSTLTIRQSL DLFLPDKTAS GLNKSQILEM NQKKSDTSML SPLNAARCQD EKAHLPTMKS FGTHRRVTHK PNLLGSKWFI KILKRHFSSV STETFVPKQD FPQVKRPLKA SRTRQPSRTN LPVLSVNEDL MHCTAFATAD EYHLGNLSQD LASHGYVEVT SLPRDAANIL VMGVENSAKE GDPGTIFFFR EGAAVFWNVK DKTMKHVMKV LEKHEIQPYE IALVHWENEE LNYIKIEGQS KLHRGEIKLN SELDLDDAIL EKFAFSNALC LSVKLAIWEA SLDKFIESIQ SIPEALKAGK KVKLSHEEVM QKIGELFALR HRINLSSDFL ITPDFYWDRE NLEGLYDKTC QFLSIGRRVK VMNEKLQHCM ELTDLMRNHL NEKRALRLEW MIVILITIEV MFELGRVFF
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome.
  • 基因功能參考文獻：
    1. Hearing impairment and renal failure are associated with RMND1 mutations. PMID: 26395190
    2. Expression of ESR1, RMND1 and CCDC170 associated with variants in separate enhancer elements predisposing breast cancer. [meta-analysis] PMID: 26928228
    3. Results demonstrate that the RMND1 complex is necessary for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome. PMID: 23022098
    4. The RMND1 mutation caused haploinsufficiency that was rescued by overexpression of the wild-type transcript in mutant fibroblasts; this overexpression increased the levels and activities of mitochondrial respiratory-chain proteins. PMID: 23022099
  • 相關疾病：
    Combined oxidative phosphorylation deficiency 11 (COXPD11)
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    RMD1/sif2 family
  • 數據庫鏈接：

    HGNC: 21176

    OMIM: 614917

    KEGG: hsa:55005

    STRING: 9606.ENSP00000356272

    UniGene: Hs.486835



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