在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Repulsive guidance molecule A (RGMA)

In Stock
  • 中文名稱:
    人RGMA重組蛋白
  • 貨號(hào):
    CSB-BP836186HUd8
  • 規(guī)格:
    ¥3168
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    Repulsive guidance molecule A; RGM; RGM domain family member A; RGMA; RGMA_HUMAN
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    Baculovirus
  • 分子量:
    72.5 kDa
  • 表達(dá)區(qū)域:
    169-424aa
  • 氨基酸序列
    PHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNKDKLHLYERTRDLPGRA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal MBP-tagged and C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
  • 基因功能參考文獻(xiàn):
    1. Dysregulation of RGMa plays an important role in the pathology of Parkinson's disease. PMID: 28842419
    2. Thus, we conclude that RGMa inhibits angiogenesis in vitro and in vivo suggesting that its manipulation would be an efficient therapeutic strategy for pro-angiogenic conditions. PMID: 26721439
    3. RGMa expression and promoter methylation status are closely related to colorectal cancer genesis and progression. PMID: 22367090
    4. identification of neogenin-binding site on the repulsive guidance molecule A PMID: 22396795
    5. The expression of RGMA, RGMB and RGMC was evident in most examined prostate cancer cell lines, and also in the prostate cancer tissues PMID: 22076499
    6. Reduced expression of RGMA in breast cancer was associated with breast cancer. PMID: 21617229
    7. The full-length signal peptides of RGMa is functional and furthermore that the C-domains are sufficient and essential for ER targeting, whereas the N-domains are dispensable. Thus, the N-domains are available for additional functions. PMID: 21183991
    8. RGM-A is a unique endogenous inhibitor of leukocyte chemotaxis that limits inflammatory leukocyte traffic PMID: 21467223
    9. Following central nervous system injury, RGM, a novel, potent axonal growth inhibitor, is present in axonal growth impediments: the mature myelin, choroid plexus, and components of the developing scar. PMID: 16216939
    10. RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and increased utilization of ActRIIA leads to generation of an enhanced BMP signal PMID: 17472960
    11. detected a homozygous deletion of chromosomal region 15q26.2 in the cell line HDLM2 encompasing RGMA and CHD2 PMID: 17606441
    12. this study, we show that Unc5B, a member of the netrin receptor family, interacts with neogenin as a coreceptor for RGMa. PMID: 19273616
    13. Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms. PMID: 19303019

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族:
    Repulsive guidance molecule (RGM) family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 30308

    OMIM: 607362

    KEGG: hsa:56963

    STRING: 9606.ENSP00000452126

    UniGene: Hs.271277



主站蜘蛛池模板: www国产精品内射熟女| 天堂无码人妻精品av一区 | 四虎成人精品无码| 国产 中文 制服丝袜 另类| 97se亚洲综合自在线| 国产精久久一区二区三区| 黑鬼大战白妞高潮喷白浆| 最新日韩精品中文字幕| 波多野结衣一区二区免费视频| 欧美精品九九久久久久久久久 | 久久www免费人成_看片| 国产亚洲日韩欧美另类第八页| 天天av天天翘天天综合网| 丁香五月亚洲中文字幕| 97成人精品国语自产拍| 日韩欧美成人免费观看| 极品美女扒开粉嫩小泬| 成人免费乱码大片a毛片| 色欲av久久综合人妻无码| 呻吟国产av久久一区二区| 成人网站免费观看入口| 全部免费毛片在线播放| 婷婷色婷婷开心五月四房播播 | 新香蕉少妇视频网站| 国产三级视频在线观看视| 亚洲日本在线在线看片| 看国产黄大片在线观看| 精品无码av一区二区三区| 中文字幕av无码不卡| 高级会所人妻互换94部分| 精人妻无码一区二区三区| 日本黄页网站免费大全| 日产精品一二三区| 天下第一社区视频www日本| 日韩高清成片免费视频| 丝袜老师办公室里做好紧好爽 | 国产福利酱国产一区二区| 无码任你躁久久久久久老妇蜜桃| av无码免费岛国动作片片段欣赏网| 国内揄拍国内精品人妻| 日本黄页网站免费观看|