在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RGMA Antibody, FITC conjugated

RGMA Antibody, FITC conjugated

  • 中文名稱：
    RGMA兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA836186LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RGMA Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Repulsive guidance molecule A antibody; RGM antibody; RGM domain family member A antibody; RGMA antibody; RGMA_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Repulsive guidance molecule A protein (153-408AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
  • 基因功能參考文獻：
    1. Dysregulation of RGMa plays an important role in the pathology of Parkinson's disease. PMID: 28842419
    2. Thus, we conclude that RGMa inhibits angiogenesis in vitro and in vivo suggesting that its manipulation would be an efficient therapeutic strategy for pro-angiogenic conditions. PMID: 26721439
    3. RGMa expression and promoter methylation status are closely related to colorectal cancer genesis and progression. PMID: 22367090
    4. identification of neogenin-binding site on the repulsive guidance molecule A PMID: 22396795
    5. The expression of RGMA, RGMB and RGMC was evident in most examined prostate cancer cell lines, and also in the prostate cancer tissues PMID: 22076499
    6. Reduced expression of RGMA in breast cancer was associated with breast cancer. PMID: 21617229
    7. The full-length signal peptides of RGMa is functional and furthermore that the C-domains are sufficient and essential for ER targeting, whereas the N-domains are dispensable. Thus, the N-domains are available for additional functions. PMID: 21183991
    8. RGM-A is a unique endogenous inhibitor of leukocyte chemotaxis that limits inflammatory leukocyte traffic PMID: 21467223
    9. Following central nervous system injury, RGM, a novel, potent axonal growth inhibitor, is present in axonal growth impediments: the mature myelin, choroid plexus, and components of the developing scar. PMID: 16216939
    10. RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and increased utilization of ActRIIA leads to generation of an enhanced BMP signal PMID: 17472960
    11. detected a homozygous deletion of chromosomal region 15q26.2 in the cell line HDLM2 encompasing RGMA and CHD2 PMID: 17606441
    12. this study, we show that Unc5B, a member of the netrin receptor family, interacts with neogenin as a coreceptor for RGMa. PMID: 19273616
    13. Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms. PMID: 19303019

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Repulsive guidance molecule (RGM) family
  • 數據庫鏈接：

    HGNC: 30308

    OMIM: 607362

    KEGG: hsa:56963

    STRING: 9606.ENSP00000452126

    UniGene: Hs.271277



主站蜘蛛池模板： 亚洲国产精品无码久久青草| 国产熟女一区二区三区五月婷| 解开人妻的裙子猛烈进入| 狠狠cao2020高清视频| 天堂亚洲2017在线观看| 亚洲一卡二卡三卡四卡无卡麻豆| 美女视频黄是免费| 久久不见久久见免费影院www日本 99久久无色码中文字幕 | 强行交换配乱婬bd| 8ⅹ8x擦拨擦拨成人免费视频| 免费1级做爰片在线观看爱| 无套内谢孕妇毛片免费看看| 丰满诱人的人妻3| 中文字幕+乱码+中文乱码www | 久久大蕉香蕉免费| 欧洲精品卡一卡二卡三| 亚洲精品无码一区二区| 国产成人av综合久久| 久久久噜噜噜久久熟女| 中国老熟女重囗味hdxx| 国产av无码专区亚洲a∨毛片| 亚洲高清国产拍精品网络战| 精品日韩亚洲欧美高清a| 又硬又粗进去好爽免费| 国产精品无码午夜福利| 亚洲熟妇久久精品| 国产成人8x人在线视频软件| 综合色就爱涩涩涩综合婷婷| 国产疯狂伦交大片| 国产精品午夜福利视频234区 | 国产精品99久久久精品无码| 青草伊人久久综在合线亚洲观看 | 激情偷乱人伦小说视频| 亚洲成αv人片在线观看| 国产精品无码久久久久久 | 欧美成人看片黄a免费看| av无码人妻一区二区三区牛牛 | 强行从后面挺进人妻| 毛片免费视频肛交颜射免费视频| 狠狠亚洲婷婷综合色香五月排名| 影音先锋无码a∨男人资源站|