在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RGMA Antibody, FITC conjugated

RGMA Antibody, FITC conjugated

  • 中文名稱：
    RGMA兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA836186LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RGMA Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Repulsive guidance molecule A antibody; RGM antibody; RGM domain family member A antibody; RGMA antibody; RGMA_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Repulsive guidance molecule A protein (153-408AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
  • 基因功能參考文獻：
    1. Dysregulation of RGMa plays an important role in the pathology of Parkinson's disease. PMID: 28842419
    2. Thus, we conclude that RGMa inhibits angiogenesis in vitro and in vivo suggesting that its manipulation would be an efficient therapeutic strategy for pro-angiogenic conditions. PMID: 26721439
    3. RGMa expression and promoter methylation status are closely related to colorectal cancer genesis and progression. PMID: 22367090
    4. identification of neogenin-binding site on the repulsive guidance molecule A PMID: 22396795
    5. The expression of RGMA, RGMB and RGMC was evident in most examined prostate cancer cell lines, and also in the prostate cancer tissues PMID: 22076499
    6. Reduced expression of RGMA in breast cancer was associated with breast cancer. PMID: 21617229
    7. The full-length signal peptides of RGMa is functional and furthermore that the C-domains are sufficient and essential for ER targeting, whereas the N-domains are dispensable. Thus, the N-domains are available for additional functions. PMID: 21183991
    8. RGM-A is a unique endogenous inhibitor of leukocyte chemotaxis that limits inflammatory leukocyte traffic PMID: 21467223
    9. Following central nervous system injury, RGM, a novel, potent axonal growth inhibitor, is present in axonal growth impediments: the mature myelin, choroid plexus, and components of the developing scar. PMID: 16216939
    10. RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and increased utilization of ActRIIA leads to generation of an enhanced BMP signal PMID: 17472960
    11. detected a homozygous deletion of chromosomal region 15q26.2 in the cell line HDLM2 encompasing RGMA and CHD2 PMID: 17606441
    12. this study, we show that Unc5B, a member of the netrin receptor family, interacts with neogenin as a coreceptor for RGMa. PMID: 19273616
    13. Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms. PMID: 19303019

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Repulsive guidance molecule (RGM) family
  • 數據庫鏈接：

    HGNC: 30308

    OMIM: 607362

    KEGG: hsa:56963

    STRING: 9606.ENSP00000452126

    UniGene: Hs.271277



主站蜘蛛池模板： 亚洲精品无码成人片久久| 中国大陆高清aⅴ毛片| 国产综合色在线视频区| 国产无套粉嫩白浆在线| 18禁真人抽搐一进一出免费| 2019久久久最新精品| 国产萌白酱喷水视频在线观看| 亚洲人成在线影院| 国产精品美女久久久久久| 国产aⅴ视频免费观看| 精品国产第一福利网站| 日本又黄又爽又色又刺激的视频| 无码人妻一区二区三区在线| 亚洲中文字幕久久无码| 在线日产精品一区| 亚洲精品综合欧美一区二区三区| 国产偷国产偷亚洲高清app| 色一情一乱一伦| 亚洲人成在线观看网站不卡 | 亚洲a∨国产av综合av网站| 无人去码一码二码三码区| 激情综合色五月丁香六月欧美| 日韩精品人妻系列无码专区免费| 久久综合色一综合色88| 亚洲欧美日韩国产自偷| 特级精品毛片免费观看| 韩国三级hd中文字幕| 国产午夜无码片在线观看影视 | 亚洲日韩精品无码专区| 久久久久无码中| 男女下面一进一出好爽视频| 久久亚洲精品人成综合网| 国产午夜精品一区二区三区四区 | 不卡无码av一区二区三区| 国产精品无码久久综合网| 小宝极品内射国产在线| 女人被狂躁到高潮视频免费软件 | 日韩精品亚洲色大成网站| 精品亚洲成a人无码成a在线观看| 无码中文av有码中文av| 双腿高潮抽搐喷白浆视频|