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  4. Recombinant Human Regulating synaptic membrane exocytosis protein 2 (RIMS2), partial

Recombinant Human Regulating synaptic membrane exocytosis protein 2 (RIMS2), partial

  • 中文名稱：
    人RIMS2重組蛋白
  • 貨號：
    CSB-YP892173HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RIMS2重組蛋白
  • 貨號：
    CSB-EP892173HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RIMS2重組蛋白
  • 貨號：
    CSB-EP892173HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RIMS2重組蛋白
  • 貨號：
    CSB-BP892173HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RIMS2重組蛋白
  • 貨號：
    CSB-MP892173HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RIMS2
  • Uniprot No.：
  • 別名：
    KIAA0751; Non small cell lung cancer RimL3a protein; Non small cell lung cancer RimL3c protein; OBOE; Protein regulating synaptic membrane exocytosis 2; Rab-3-interacting molecule 2; Rab-3-interacting protein 3; Rab3 interacting molecule 2; RAB3IP3; Regulating synaptic membrane exocytosis 2; Regulating synaptic membrane exocytosis protein 2; RIM 2; Rims2 (gene name); Rims2; RIMS2_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes.
  • 基因功能參考文獻(xiàn)：
    1. Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 variant containing the region encoded by exons 44 and 47. PMID: 28377503
    2. Here, we report that, like Rab3A, RIM and Munc13 are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux PMID: 22248876
    3. These data suggest that RIM2beta contributes to the stabilization of Ca(v)1.3 gating kinetics in immature cochlear inner hair cells. PMID: 20363327
    4. Western blot analysis shows increased RIMS2 protein expression in the amygdala in schizophrenia. PMID: 18490030
    5. tick-borne encephalitis virus -NS5 has high affinity to regulating synaptic membrane exocytosis-2 (RIMS2) and Scribble, whereas DENV-NS5 binds primarily to the tight junction protein zonula occludens-1 (ZO-1) PMID: 19199833

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  • 亞細(xì)胞定位：
    Cell membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein.
  • 組織特異性：
    Widely expressed. Expressed in melanocytes. In fetal tissues, predominantly expressed in the brain. In the retina, expressed in the outer plexiform layer (at protein level). In the cerebellum, expressed in Purkinje cells (at protein level). In the pancrea
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17283

    OMIM: 606630

    KEGG: hsa:9699

    UniGene: Hs.655271



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