在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Receptor-type tyrosine-protein phosphatase T (PTPRT), partial

In Stock
  • 中文名稱:
    人PTPRT重組蛋白
  • 貨號:
    CSB-MP019065HU
  • 規(guī)格:
    ¥1536
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    Receptor-type tyrosine-protein phosphatase rho;RPTP-rho;R-PTP-T
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    Mammalian cell
  • 分子量:
    109.2 kDa
  • 表達(dá)區(qū)域:
    26-747aa
  • 氨基酸序列
    QSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVEPEKQVDNTVKM
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    C-terminal hFc1-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    May be involved in both signal transduction and cellular adhesion in the CNS.
  • 基因功能參考文獻(xiàn):
    1. The single cell genotyping not only confirmed the co-occurrence of the PTPRT, CAND1 and DOCK6 mutations in the same AML clone but also revealed a clonal hierarchy, as the PTPRT mutation was likely acquired after the CAND1 and DOCK6 mutations. PMID: 27244256
    2. PTPRT promoter methylation is significantly associated with sensitivity to STAT3 inhibition in HNSCC cells, suggesting that PTPRT promoter methylation may serve as a predictive biomarker for responsiveness to STAT3 inhibitors in clinical development PMID: 25982282
    3. Data reported evidence that rs2866943 polymorphism in PTPRT 3'-UTR was involved in the occurrence of esophageal squamous cell carcinoma by acting as a protective factor while rs6029959 acts as a risk factor. PMID: 25967969
    4. Data show that hepatitis B virus X protein mutant HBxDelta127 enhances proliferation of hepatoma cells through up-regulating miR-215 targeting protein tyrosine phosphatase, receptor type T (PTPRT). PMID: 24434140
    5. tumor-specific mutational events in the PTPRT gene can serve as direct drivers for tumor growth by inducing hyperactivation of STAT3, a potent oncogenic transcription factor and PTPRT substrate PMID: 24395800
    6. The catalytic domain point mutants show a decreased thermal and thermodynamic stability and decreased activation energy relative to phosphatase activity, when compared to wild- type PMID: 22389709
    7. [review] High-throughput mutational analysis identifies loss-of-function mutations in six PTPs in human colon cancers, providing critical cancer genetics evidence that PTPs can act as tumour suppressor genes. PMID: 21517784
    8. Data show that paxillin is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin phosphorylation at tyrosine residue 88(Y88). PMID: 20133777
    9. alterations of the PTPRT-mediated signaling pathway by PTPRT phosphatase domain mutation may not play a critical role in the development of common human cancers PMID: 17223850
    10. STAT3 is a substrate of receptor protein tyrosine phosphatase T PMID: 17360477
    11. brain-specific PTPRT regulates synapse formation through interaction with cell adhesion molecules, and this function and the phosphatase activity are attenuated through tyrosine phosphorylation by the synaptic tyrosine kinase Fyn. PMID: 19816407

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Receptor class 2B subfamily
  • 組織特異性:
    Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 9682

    OMIM: 608712

    KEGG: hsa:11122

    STRING: 9606.ENSP00000362283

    UniGene: Hs.526879



主站蜘蛛池模板: 自拍偷在线精品自拍偷99| 熟妇人妻系列aⅴ无码专区友真希| 精品久久久久久中文字幕| 黑人玩弄人妻1区二区| 香蕉啪视频在线观看视频久| 内射女校花一区二区三区| 亚洲爆乳无码精品aaa片蜜桃| 国产精品自在拍在线播放| 日本亚洲欧美日韩国产ay| 免费看又色又爽又黄的国产软件| 欧美大成色www永久网站婷| 日本在线高清不卡免费播放| 337p日本欧洲亚洲大胆艺术图| a三级三级成人网站在线视频| 麻豆亚洲一区| 成人无码视频在线观看大全| 人妻无码系列一区二区三区| 熟女少妇丰满一区二区| 最新国产乱人伦偷精品免费网站 | 亚洲中文字幕无码久久精品1| 最新69国产成人精品视频免费| 国产农村黄aaaaa特黄av毛片 | 精品人妻系列无码人妻漫画| 黑人巨茎大战欧美白妇| 久久国内精品自在自线观看| 欧美精品一区二区精品久久| 艳z门照片无码av| 免费高清av一区二区三区| 玩弄丰满少妇人妻视频| 人人妻人人澡人人爽不卡视频| 日本无翼乌邪恶大全彩h| 激情综合婷婷丁香五月情| 少妇裸交aa大片| 久久www免费人成精品| 在线亚洲综合欧美网站首页| 人妻av无码专区久久| 内射无码专区久久亚洲| 久久综合九色综合97伊人| 亚洲国产成人爱av网站| 吃奶呻吟打开双腿做受动态图 | 99e热久久免费精品首页|