在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Ras GTPase-activating protein SynGAP (SYNGAP1), partial

  • 中文名稱:
    人SYNGAP1重組蛋白
  • 貨號:
    CSB-YP857006HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人SYNGAP1重組蛋白
  • 貨號:
    CSB-EP857006HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人SYNGAP1重組蛋白
  • 貨號:
    CSB-BP857006HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人SYNGAP1重組蛋白
  • 貨號:
    CSB-MP857006HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    DKFZp761G1421 ; KIAA1938; MRD5; Neuronal RasGAP; OTTHUMP00000064825; p135 SynGAP; Ras GTPase activating protein SynGAP; Ras GTPase-activating protein SynGAP; RASA 1; RASA 5; RASA1; RASA5; SYGP1_HUMAN; Synaptic Ras GAP 1; Synaptic Ras GTPase activating protein 1; Synaptic Ras GTPase activating protein 1 homolog; Synaptic Ras GTPase activating protein 135kDa; Synaptic Ras GTPase activating protein; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; SYNGAP 1; SYNGAP1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.
  • 基因功能參考文獻:
    1. De novo, heterozygous, loss-of-function mutations in SYNGAP1 cause a syndromic form of intellectual disability. PMID: 26079862
    2. This is the first description of a special electroencephalogram phenomenon (normalization with eye opening) in association with SYNGAP1 mutations. PMID: 26110312
    3. Syngap transgenic mice exhibited alterations in long-term depression and dendritic spine morphology. PMID: 26558778
    4. Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases. PMID: 25533468
    5. Reduced cognition in mutant Syngap1 transgenic mice is caused by isolated damage to developing forebrain neurons. PMID: 24945774
    6. De novo CHD2 and SYNGAP1 mutations are new causes of epileptic encephalopathies, accounting for 1.2% and 1% of cases, respectively. PMID: 23708187
    7. De novo missense mutations, p.R579X, and possibly all the other truncating mutations in SYNGAP1 result in a loss of its function, causing intellectual disability, autism, and a specific form of epilepsy. PMID: 23161826
    8. SYNGAP1 is a brain-specific protein that interacts with key components of the proteins involved in experience-dependent changes in glutamate synapses involved in learning. PMID: 21480541
    9. We provide evidence that truncating mutations in SYNGAP1 are common in nonsyndromic intellectual disability and can be also associated with autism. PMID: 21237447
    10. The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction. PMID: 18323856
    11. Results indicate that SYNGAP1 disruption is a cause of autosomal dominant nonsyndromic mental retardation. PMID: 19196676

    顯示更多

    收起更多

  • 相關疾病:
    Mental retardation, autosomal dominant 5 (MRD5)
  • 數據庫鏈接:

    HGNC: 11497

    OMIM: 603384

    KEGG: hsa:8831

    STRING: 9606.ENSP00000403636

    UniGene: Hs.586264



主站蜘蛛池模板: 蜜桃臀无码内射一区二区三区| 日本亚欧热亚洲乱色视频| 人成午夜免费视频无码| 亚洲熟女乱色综合亚洲小说| 成人av片无码免费网站| 成在线人免费无码高潮喷水 | 成人性生交大片免费看r老牛网站| 免费人成视频网站在线下载| 精品少妇无码一区二区三批 | 国产乱来乱子视频| 国产极品精品自在线| 久久久99精品成人片| 欧美黑人巨大xxxxx视频| 中国极品少妇videossexhd| 久久国产精品免费一区二区三区 | 亚洲乱码一卡二卡卡3卡4卡| 性欧美丰满熟妇xxxx性| 无套内谢老熟女| 无码国产欧美一区二区三区不卡 | 国产在线不卡视频免费视频| 久久无码喷吹高潮播放不卡 | 五月婷婷开心中文字幕| 天天躁日日躁狠狠躁2018| 日韩视频无码免费一区=区三区| 欧美搡bbbbb搡bbbbb| 我的公把我弄高潮了视频| 国产黄在线观看免费观看不卡| 免费无码久久成人网站入口 | 嫩草欧美曰韩国产大片| 无码毛片视频一区二区本码| 精品国产成人一区二区三区| 婷婷激情综合色五月久久竹菊影视 | 国产又大又黑又粗免费视频| 精品久久久久久久免费人妻| 成人h动漫无码网站久久| 色屁屁www影院免费观看| 一个人看的www日本高清视频| 天堂aⅴ无码一区二区三区| 国产成人午夜福利电影在线播放| 麻花传媒在线观看免费| 国产精品高清视亚洲中文|