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  4. Recombinant Human Ras GTPase-activating-like protein IQGAP1 (IQGAP1), partial

Recombinant Human Ras GTPase-activating-like protein IQGAP1 (IQGAP1), partial

  • 中文名稱：
    Recombinant Human Ras GTPase-activating-like protein IQGAP1 (IQGAP1), partial
  • 貨號：
    CSB-EP011800HU
  • 規(guī)格：
    ￥1536
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    30.7 kDa
  • 表達(dá)區(qū)域：
    505-717aa
  • 氨基酸序列
    KAQAHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest.
  • 基因功能參考文獻(xiàn)：
    1. MTA1 participates in Nasopharyngeal carcinoma malignant transformation via regulating IQGAP1 expression and PI3K/Akt signaling pathway. PMID: 29125886
    2. High IQGAP1 expression is associated with angiogenesis of esophageal squamous cell carcinoma. PMID: 30015941
    3. over-expression of IQGAP1 in human head and neck squamous cell carcinoma may indicate poor prognosis. PMID: 29846864
    4. IQGAP1 plays an important role in the cell proliferation and invasion of human breast cancer cells. PMID: 29779034
    5. These results show for the first time that IQGAP1 is up-regulated in Laryngeal squamous cell carcinoma (LSCC)tissues and plays an important role in LSCC cell proliferation and invasiveness, which indicates that IQGAP1 could work as an oncogene and may serve as a promising molecular target for treatment of LSCC. PMID: 28708206
    6. High IQGAP1 expression is associated with invasion in endometrial cancer. PMID: 26934121
    7. Examined the expression of IQGAP1 in different pancreatic cancer cell lines and we found that IQGAP1 level is highly correlated with the degree of malignancy of pancreatic cancer cell metastasis. The proliferation, metastasis, motility and tumorigenesis in SW1990 human pancreatic cells were greatly impaired by down-regulating IQGAP1 expression with RNA interference. PMID: 27100492
    8. Findings discover the IQGAP1 SUMOylation is a novel regulatory mechanism to enhance tumorigenesis and development of CRC in vitro and in vivo. PMID: 28987385
    9. IQGAP1 may have a role in podocyte gene regulation in glomerular disease. PMID: 27377965
    10. the results show that IQGAP1 is a novel regulator of type I IFN production, possibly via interacting with NLRC3 in human monocytic and epithelial cells PMID: 28864474
    11. The structural basis for Cdc42-induced dimerization of IQGAP1 and IQGAP2 has been uncovered. PMID: 27524202
    12. findings suggest a novel role of IQGAP1 in insulin-regulated interaction between caveolae and cytoskeletal elements of the adipocyte, and that this is quelled in the diabetic state PMID: 27458251
    13. Alterated IQGAP1/Rho GTPase signaling in myeloproliferative neoplasm erythrocytes is dependent on JAK2/CALR mutational status. PMID: 27566291
    14. our data suggest that IQ-domain GTPase-activating protein 1 may promote the malignant phenotype of invasive ductal carcinoma via canonical Wnt signaling, and it could be used as a potential prognostic biomarker for breast cancer patients. PMID: 28618949
    15. IQ domain of IQGAP1 is both necessary and sufficient for binding to ERK1 and ERK2, as well as to the MAPK kinases MEK1 and MEK2. PMID: 28396345
    16. Data indicate that the IQGAP1 N-terminal fragment spanning residues 1-191 (CHDF) binds to both F-actin and Ca(2+)/calmodulin. PMID: 27798963
    17. These data were confirmed by phosphomimetic mutation of serine 1443 to glutamate within RGCT, which led to a significant reduction of IQGAP1 affinity for CDC42 and RAC1, clearly disclosing the critical role of RGCT for these interactions. PMID: 27815503
    18. These data reveal that IQGAP1 binds to YAP and modulates its co-transcriptional function, suggesting that IQGAP1 participates in Hippo signaling. PMID: 27440047
    19. The results indicated that IQGAP1 was expressed at higher levels in glioma tissues compared with in normal brain tissues. IQGAP1siRNA significantly inhibited cell proliferation, and cell adhesion, migration and invasion. PMID: 28259970
    20. IQGAP1 protein is involved in normal cell physiology as well as oncologic processes. PMID: 28098764
    21. after AKT-mediated phosphorylation at serine 319, FOXO1 binds to IQGAP1, a hub for activation of the MAPK pathway, and impedes IQGAP1-dependent phosphorylation of ERK1/2 (pERK1/2). PMID: 28279977
    22. High expression of IQGAP1 is associated with glioma. PMID: 28035419
    23. High IQGAP1 expression is associated with hepatocellular carcinoma. PMID: 27488117
    24. MALAT1 promoted the proliferation and invasion of thyroid cancer cells via regulating the expression of IQGAP1. PMID: 27470543
    25. IQGAP1 interaction with PIPKIgamma regulates cell motility and cell signaling. [review] PMID: 26554303
    26. Results show that one actin binding domain in IQGAP1 protein and predict the interaction likely to involve an electrostatic interaction between Lys-240 of alpha-actin and Glu-30 of CHD1. PMID: 26845769
    27. At the cleavage furrow Arv1 recruits myosin heavy chain 9 (MYH9) and myosin light chain 9 (MYL9) by interacting with IQ-motif-containing GTPase-activating protein (IQGAP1). PMID: 27104745
    28. Our data indicate a possible regulatory role for the multiple sclerosis-associated IKZF3 and IQGAP1 variants. PMID: 27080863
    29. the present study is the first to provide evidence that miR-506 acts as a tumor suppressor, at least partially, by directly downregulating IQGAP1 in breast cancer cells. PMID: 26398880
    30. The clinical relevance of IQGAP1 as a tumor growth suppressor is supported by the finding that its expression is lower in bladder cancer compared with benign patient urothelium in multiple independent datasets. PMID: 26078295
    31. the overexpression and interactions of IQGAP1 and beta-catenin contribute to hepatocellular carcinoma progression by promoting cell proliferation and migration. PMID: 26252773
    32. Down-regulation of caveolin-1 or IQGAP1 in PC-3 cells reduced migration and invasion in vitro, and hypercholesterolemia-induced metastasis in vivo. PMID: 25924234
    33. Our results identify OspB as a regulator of mTORC1 and mTORC1-dependent cell proliferation early during S. flexneri infection and establish a role for IQGAP1 in mTORC1 signaling PMID: 26473364
    34. Depletion of IQGAP1 disrupts nuclear envelope localization and delays abscission timing. PMID: 25928398
    35. IQGAP1 and its two isoforms regulate the actin-cytoskeleton alone and with their binding partners, Rac and Cdc42, thereby controlling diverse cellular processes, such as cell migration and adhesion. (Review) PMID: 26051604
    36. IQGAP1 may directly interact with estrogen receptor alpha and serve as a signal integrator, mediating estrogen receptor alpha transcriptional activity, cell proliferation and cell invasion during the progression of thyroid cancer. PMID: 26046126
    37. Increased IQGAP1 expression during the differentiation of cancer stem cell-like cells is involved in an aggressive cell behavior, which may contribute to metastasis of ovarian cancer. PMID: 25675045
    38. These data indicated that TGF-beta inhibited IQGAP1 expression in lung fibroblasts via the NF-kappaB signaling pathway, presenting a potential novel therapeutic target for the treatment of idiopathic pulmonary fibrogenesis . PMID: 25684348
    39. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardiovascular system, pancreas, and lung. (Review) PMID: 25722290
    40. Activated IQGAP1, as an intracellular partner of nephrin, is involved in actin cytoskeleton organization and functional regulation of podocytes. PMID: 25652011
    41. Mechanistically, the N-terminal of SKAP binds to EB1, and its C terminus binds to IQGAP1 in migrating cells. PMID: 26242911
    42. There was a positive correlation between DNAJB6 and IQGAP1 expression. PMID: 25044025
    43. IQGAP1 expression in podocyte under high glucose media is modulated by the ERK1/2 pathway. PMID: 24488174
    44. Study shows that miR-124a expression was downregulated in human glioma tissues, and its expression level was negatively correlated with the pathological grade. Also, the data shows that IQGAP1 is a direct target of miR-124a. PMID: 25175832
    45. these results suggest that a labile pool of IQGAP1 at intercellular junctions disassembles adherens junctions and thus impairs endothelial cell-cell adhesion. PMID: 23807500
    46. Results show that coexpression of IQGAP1 and Dvl in the cytoplasm and nucleus was correlated with the lymph nodal metastase and poor prognosis of non-small cell lung cancer. PMID: 25436461
    47. IQGAP1 may regulate the phenotypic switch of venous smooth muscle cells by myocardin pathway, which is critical for the pathological progression of varicose vein. PMID: 25400725
    48. Data indicate that quercetin inhibited the interaction between IQ motif-containing GTPase activating protein 1 (IQGAP1) and extracellular signal-regulated kinases ERK1/2 in RPMI8226 multiple myeloma cells. PMID: 24397597
    49. Genetic variation within IQGAP1 is associated with cognitive function. PMID: 25222038
    50. IQGAP1 as an essential regulator of the MAPK and Wnt/beta-catenin signaling pathways. PMID: 25733387

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  • 亞細(xì)胞定位：
    Cell membrane. Nucleus. Cytoplasm.
  • 組織特異性：
    Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6110

    OMIM: 603379

    KEGG: hsa:8826

    STRING: 9606.ENSP00000268182

    UniGene: Hs.430551



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