在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human RNA-binding protein with multiple splicing (RBPMS)

In Stock
  • 中文名稱:
    人RBPMS重組蛋白
  • 貨號:
    CSB-EP821892HU
  • 規格:
    ¥1836
  • 圖片:
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP821892HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) RBPMS.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP821892HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) RBPMS.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    RBPMS
  • Uniprot No.:
  • 別名:
    FLJ32971; Heart and RRM expressed sequence; Hermes; RBP MS; RBP-MS; Rbpms; RBPMS_HUMAN; RNA binding protein gene with multiple splicing; RNA-binding protein with multiple splicing
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    28.8 kDa
  • 表達區域:
    1-196aa
  • 氨基酸序列
    MNNGGKAEKENTPSEANLQEEEVRTLFVSGLPLDIKPRELYLLFRPFKGYEGSLIKLTSKQPVGFVSFDSRSEAEAAKNALNGIRFDPEIPQTLRLEFAKANTKMAKNKLVGTPNPSTPLPNTVPQFIAREPYELTVPALYPSSPEVWAPYPLYPAELAPALPPPAFTYPASLHAQMRWLPPSEATSQGWKSRQFC
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.
  • 基因功能參考文獻:
    1. The possible involvement of the GC box 1 at position - 54 in transcriptional regulation of Rbpms was corroborated by EMSA, which showed formation of a DNA-protein complex in the presence of the oligonucleotide corresponding to this Sp1-binding site. PMID: 29423656
    2. Data indicate RNA Binding Protein with Multiple Splicing (RBPMS), Regulator of Chromosome Condensation and POZ Domain Containing Protein 1 (RCBTB1), and Zinc Finger protein 608 (ZNF608) as miR-21-3p target genes. PMID: 27166999
    3. Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family has been reported. PMID: 28003515
    4. ERG is recruited to mRNAs via interaction with the RNA-binding protein RBPMS, and it promotes mRNA decay by binding CNOT2, a component of the CCR4-NOT deadenylation complex. PMID: 27273514
    5. observation of a strong in vivo erythropoietic effect for RBPMS but not for GTF2E2, supporting the statistical fine-mapping at this locus and demonstrating that RBPMS is a regulator of erythropoiesis PMID: 28017375
    6. Study indicates that the RNA binding increases the stability of RNA-recognition motif (RRM) in RBPMS domain, but residue mutations of RRM domain induce the fluctuation of complex systems through weakening of hydrogen bonds, conformational change or loss of binding affinity. PMID: 27592836
    7. RBPMS1 is a critical repressor of AP-1 signaling and RBPMS1 activation may be a useful strategy for cancer treatment. PMID: 25281386

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Cytoplasm, P-body.
  • 組織特異性:
    Ubiquitously expressed, at various levels depending on the isoform and the tissue.
  • 數據庫鏈接:

    HGNC: 19097

    OMIM: 601558

    KEGG: hsa:11030

    STRING: 9606.ENSP00000340176

    UniGene: Hs.334587



主站蜘蛛池模板: 国精产品999一区二区三区有限| 中文字幕日本六区小电影| 寂寞少妇做spa按摩无码| 狠狠色狠狠人格综合| 免费无码成人av在线播放不卡| 婷婷伊人久久大香线蕉av| а天堂中文最新一区二区三区| 小蜜被两老头吸奶头在线观看| 青青国产揄拍视频| 免费不卡无码av在线观看| 欧美日韩中文国产一区发布| 丁香色婷婷国产精品视频| 亚洲精品无人区| 啪啪激情婷婷久久婷婷色五月| aⅴ亚洲 日韩 色 图网站 播放| 业余 自由 性别 成熟偷窥| 久久精品国产精品亚洲下载| 2020精品国产视| 国产98在线 | 欧美| 亚洲国产精品无码久久98| 国产伦子系列沙发午睡| 亚洲综合无码一区二区三区不卡| 日韩欧美群交p片內射中文| 精品乱码一区二区三四区视频| 国产成人亚洲精品无码蜜芽| 天堂va欧美ⅴa亚洲va在线| 丰满熟妇被猛烈进入高清片| 精品夜夜澡人妻无码av| 精品视频国产狼友视频| 国产精品久久久久久影视不卡| 少妇久久久久久被弄到高潮| 女人张开双腿让男人猛桶| 亚洲一区精品无码色成人| 337p粉嫩大胆色噜噜噜| 国产综合色产在线精品| 久久99国产精品二区| 欧洲无码一区二区三区在线观看| 国产亚洲精品久久777777| 欧美日激情日韩精品嗯| 亚洲免费视频免在线观看| 少妇人妻精品一区二区三区|