在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human RING finger protein 183 (RNF183), partial

  • 中文名稱:
    人RNF183重組蛋白
  • 貨號:
    CSB-YP019862HU1
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人RNF183重組蛋白
  • 貨號:
    CSB-EP019862HU1
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人RNF183重組蛋白
  • 貨號:
    CSB-EP019862HU1-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人RNF183重組蛋白
  • 貨號:
    CSB-BP019862HU1
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人RNF183重組蛋白
  • 貨號:
    CSB-MP019862HU1
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    RNF183
  • Uniprot No.:
  • 別名:
    RNF183; E3 ubiquitin-protein ligase RNF183
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling.
  • 基因功能參考文獻:
    1. RNF183 plays an important role in executing programmed cell death upon prolonged endoplasmic reticulum stress, likely by inducing apoptosis through Bcl-xL.RNF183 ubiquitinates Bcl-xL. PMID: 29507230
    2. RNF183 promotes proliferation and metastasis of colorectal cancer cells via activation of NF-kappaB-IL-8 axis PMID: 28796265
    3. The RNF183-IL-8 axis is responsible for the resistance of colorectal cancer (CRC)cells to the MEK1/2 inhibitor trametinib and may serve as a candidate target for combined therapy for CRC. PMID: 28756770
    4. Sec16A also stabilized the interacting ubiquitin ligase RNF152, which localizes to the lysosome and has structural similarity with RNF183 PMID: 29300766
    5. RNF183, which is negatively regulated by miR-7, is a novel regulator promoting intestinal inflammation by increasing the ubiquitination and degradation of IkappaBalpha, thereby inducing NF-kappaB activation. The interaction between RNF183-mediated ubiquitination and miRNA may be an important novel epigenetic mechanism in the pathogenesis of inflammatory bowel disease. PMID: 26818663

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum. Golgi apparatus, cis-Golgi network membrane. Lysosome membrane.
  • 組織特異性:
    Kidney and testis.
  • 數據庫鏈接:

    HGNC: 28721

    KEGG: hsa:138065

    UniGene: Hs.729641



主站蜘蛛池模板: 欲色影视天天一区二区三区色香欲 | 国精产品999国精产品官网| 欧美人和黑人牲交网站上线| 亚洲欧美精品aaaaaa片| 国产在线观看无码的免费网站 | 久久青青草原国产免费播放| 久久天天躁夜夜躁狠狠85| 国产偷国产偷亚州清高app| 精品无码国产一区二区三区51安| 精品人妻无码区在线视频| 亚洲精品日韩一区二区小说| 色综合伊人色综合网站无码| 激情 小说 亚洲 图片 伦| 亚洲精品亚洲人成在线| 婷婷丁香五月六月综合激情啪| 一区二区三区国产精华液| 免费看欧美成人a片无码| 国产成人无码av| 四虎亚洲精品成人a在线观看| 国产精品三级av三级av三级| 亚洲午夜精品久久久久久浪潮| 国产精品亚洲lv粉色| 精品久久久久久无码不卡| 久久无码中文字幕免费影院| 精品国产亚洲一区二区三区在线观看| 狠狠色噜噜狠狠狠狠777米奇| 在线精品视频一区二区| 久久精品国产亚洲不av麻豆| 亚洲色成人中文字幕网站| 国自产拍偷拍精品啪啪模特| 日本人妻中文字幕乱码系列| 国产一起色一起爱| 精品一区二区三区免费播放| 国内精品久久久久久久久电影网 | 欧美又大又色又爽aaaa片| 国产日韩精品欧美2020区| 92国产精品午夜福利无毒不卡| 久久久久国产精品免费免费搜索| 人人色在线视频播放| 99视频国产精品免费观看| 日本中文字幕乱码免费|