在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human REST corepressor 1 (RCOR1),Partial

Recombinant Human REST corepressor 1 (RCOR1),Partial

  • 中文名稱：
    人RCOR1重組蛋白
  • 貨號：
    CSB-YP019515HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RCOR1重組蛋白
  • 貨號：
    CSB-EP019515HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RCOR1重組蛋白
  • 貨號：
    CSB-BP019515HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RCOR1重組蛋白
  • 貨號：
    CSB-MP019515HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RCOR1
  • Uniprot No.：
  • 別名：
    COREST; KIAA0071; Nr2b2; Nuclear receptor coregulator 1; Nuclear receptor subfamily 2 group B member 2; Protein CoREST; RCOR; Rcor1; RCOR1_HUMAN; REST corepressor 1; Retinoic acid receptor RXR-beta; Retinoid X receptor beta; Rxrb
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 表達區域：
    4-485
  • 氨基酸序列
    MVEKGPEVSG KRRGRNNAAA SASAAAASAA ASAACASPAA TAASGAAASS ASAAAASAAA APNNGQNKSL AAAAPNGNSS SNSWEEGSSG SSSDEEHGGG GMRVGPQYQA VVPDFDPAKL ARRSQERDNL GMLVWSPNQN LSEAKLDEYI AIAKEKHGYN MEQALGMLFW HKHNIEKSLA DLPNFTPFPD EWTVEDKVLF EQAFSFHGKT FHRIQQMLPD KSIASLVKFY YSWKKTRTKT SVMDRHARKQ KREREESEDE LEEANGNNPI DIEVDQNKES KKEVPPTETV PQVKKEKHST QAKNRAKRKP PKGMFLSQED VEAVSANATA ATTVLRQLDM ELVSVKRQIQ NIKQTNSALK EKLDGGIEPY RLPEVIQKCN ARWTTEEQLL AVQAIRKYGR DFQAISDVIG NKSVVQVKNF FVNYRRRFNI DEVLQEWEAE HGKEETNGPS NQKPVKSPDN SIKMPEEEDE APVLDVRYAS AS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.
  • 基因功能參考文獻：
    1. the intact CoREST complex is targeted with dual histone deacetylase and demethylase inhibitors PMID: 29302039
    2. Expressions of REST and RCOR1 genes may downregulate SYN1 expression in gliomas. PMID: 27685921
    3. Rcor1 knock-out monocytes exhibited extensive self-renewal associated with hematopoietic stem cell expansion. PMID: 26119982
    4. Genomic deletions in RCOR1 are associated with a specific gene expression signature and with unfavorable clinical outcomes in diffuse large B-cell lymphoma patients. PMID: 25395426
    5. a combination of virtual screening and biological approaches can lead to compounds reducing REST complex formation PMID: 23800350
    6. Data show that miR-22 specifically interacts with the 3' UTRs of the Rcor1, Rgs2 and HDAC4 mRNAs. PMID: 23349832
    7. The CoREST and REST are necessary and inimical for expression of herpes simplex virus genes. PMID: 21221247
    8. Insight into the molecular basis of the interaction between scaffolding protein CoREST and histone deacetylase LSD1 may suggest a new means of inhibiting LSD1 activity by misdirecting the enzyme away from nucleosomal substrates. PMID: 21142040
    9. silencing of CoREST by siRNA transfection in normal articular cartilage may reflect CoREST repression in advanced osteoarthritic cartilage, which results in phenotypic genes modulation and suggests a homeostatic role of this transcription factor PMID: 20973059
    10. CoREST does not play an influential role in regulating HSV-1 infection. PMID: 20106915
    11. elevated levels of REST and CoREST in the brain of RTT patients and MeCP2 deficient mice result in downregulation of BDNF, apparently by their binding to the RE1 (element) located between the first two promoters of the BDNF gene PMID: 18075316
    12. CoREST is bound to the hsp70 gene promoter under basal conditions and that its binding increases during heat shock response. PMID: 18657505
    13. These results demonstrate that SUMO-1 modification modulates the transcriptional repression by CoREST and is needed for its full repressive activity. PMID: 18854179
    14. The results indicate that both sets of events mediated by ICP0, the degradation of PML and the blocking of silencing via the HDAC1/2-CoREST-REST complex, are interdependent and in large measure dependent on events in the ND10 nuclear bodies. PMID: 18945770
    15. Direct interactions between CoREST1 and SUMO-2 mediate SUMO-dependent changes in chromatin structure and transcription that are important for cell-type-specific gene expression. PMID: 19394292
    16. Analysis of chromatin modification patterns shows that CoREST are recruited to the c-myc promoter leading to appearance of repressive chromatin marks. PMID: 19522008

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.
  • 蛋白家族：
    CoREST family
  • 組織特異性：
    Ubiquitously expressed.
  • 數據庫鏈接：

    HGNC: 17441

    OMIM: 607675

    KEGG: hsa:23186

    STRING: 9606.ENSP00000459789

    UniGene: Hs.510521



主站蜘蛛池模板： 午夜成人爽爽爽视频在线观看| 欧美日韩欧美| 国产精品丝袜久久久久久不卡| 最新国产aⅴ精品无码| 亚洲国产日韩a在线播放| 好男人社区在线www| 日日拍夜夜嗷嗷叫国产| 无码av动漫精品一区二区免费| 人摸人人人澡人人超碰97| 天天爽夜夜爽人人爽| 无码人妻一区二区三区在线视频| 久久99精品国产自在现线小黄鸭| 黑人与中国少妇xxxx视频| 久久久亚洲精品一区二区三区浴池| 少妇挑战三个黑人惨叫4p国语| 国产综合有码无码视频在线 | 国产又爽又大又黄a片| 成人免费一区二区三区| 九九精品成人免费国产片| 色舞月亚洲综合一区二区| 伊人久久精品无码二区麻豆| 成熟丰满熟妇av无码区| 国产色播av在线观看| 亚洲伊人情人综合网站| 潮喷失禁大喷水aⅴ无码| 日韩精品毛片无码一区到三区| 精品午夜国产福利观看| 四虎精品免费永久免费视频| 丰满人妻熟妇乱偷人无码| 亚洲狠狠成人网| 92午夜福利少妇系列| 男人和女人在床的app| 欧美巨波霸乳影院| 中文字幕无码热在线视频| 中文字幕日韩一区二区不卡| 欧美国产国产综合视频| 亚洲一区无码中文字幕| 香港三级日本三级韩级人妇| 亚洲免费观看视频| 久久99精品久久久久婷婷| 国产区又黄又硬高潮的视频|