在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RCOR1 Antibody, FITC conjugated

  • 中文名稱:
    RCOR1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA019515HC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RCOR1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    RCOR1
  • 別名:
    COREST antibody; KIAA0071 antibody; Nr2b2 antibody; Nuclear receptor coregulator 1 antibody; Nuclear receptor subfamily 2 group B member 2 antibody; Protein CoREST antibody; RCOR antibody; Rcor1 antibody; RCOR1_HUMAN antibody; REST corepressor 1 antibody; Retinoic acid receptor RXR-beta antibody; Retinoid X receptor beta antibody; Rxrb antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human REST corepressor 1 protein (394-482AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.
  • 基因功能參考文獻:
    1. the intact CoREST complex is targeted with dual histone deacetylase and demethylase inhibitors PMID: 29302039
    2. Expressions of REST and RCOR1 genes may downregulate SYN1 expression in gliomas. PMID: 27685921
    3. Rcor1 knock-out monocytes exhibited extensive self-renewal associated with hematopoietic stem cell expansion. PMID: 26119982
    4. Genomic deletions in RCOR1 are associated with a specific gene expression signature and with unfavorable clinical outcomes in diffuse large B-cell lymphoma patients. PMID: 25395426
    5. a combination of virtual screening and biological approaches can lead to compounds reducing REST complex formation PMID: 23800350
    6. Data show that miR-22 specifically interacts with the 3' UTRs of the Rcor1, Rgs2 and HDAC4 mRNAs. PMID: 23349832
    7. The CoREST and REST are necessary and inimical for expression of herpes simplex virus genes. PMID: 21221247
    8. Insight into the molecular basis of the interaction between scaffolding protein CoREST and histone deacetylase LSD1 may suggest a new means of inhibiting LSD1 activity by misdirecting the enzyme away from nucleosomal substrates. PMID: 21142040
    9. silencing of CoREST by siRNA transfection in normal articular cartilage may reflect CoREST repression in advanced osteoarthritic cartilage, which results in phenotypic genes modulation and suggests a homeostatic role of this transcription factor PMID: 20973059
    10. CoREST does not play an influential role in regulating HSV-1 infection. PMID: 20106915
    11. elevated levels of REST and CoREST in the brain of RTT patients and MeCP2 deficient mice result in downregulation of BDNF, apparently by their binding to the RE1 (element) located between the first two promoters of the BDNF gene PMID: 18075316
    12. CoREST is bound to the hsp70 gene promoter under basal conditions and that its binding increases during heat shock response. PMID: 18657505
    13. These results demonstrate that SUMO-1 modification modulates the transcriptional repression by CoREST and is needed for its full repressive activity. PMID: 18854179
    14. The results indicate that both sets of events mediated by ICP0, the degradation of PML and the blocking of silencing via the HDAC1/2-CoREST-REST complex, are interdependent and in large measure dependent on events in the ND10 nuclear bodies. PMID: 18945770
    15. Direct interactions between CoREST1 and SUMO-2 mediate SUMO-dependent changes in chromatin structure and transcription that are important for cell-type-specific gene expression. PMID: 19394292
    16. Analysis of chromatin modification patterns shows that CoREST are recruited to the c-myc promoter leading to appearance of repressive chromatin marks. PMID: 19522008

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.
  • 蛋白家族:
    CoREST family
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 17441

    OMIM: 607675

    KEGG: hsa:23186

    STRING: 9606.ENSP00000459789

    UniGene: Hs.510521



主站蜘蛛池模板: 成人精品一区二区三区中文字幕| 午夜无码大尺度福利视频| 国产农村妇女aaaaa视频| 女人被男人桶30分钟无遮挡动态图| 国产高清女同学巨大乳在线观看 | 国产公妇仑乱在线观看| 亚洲中文字幕无码卡通动漫野外| 精品亚洲国产成人av不卡| 国产裸拍裸体视频在线观看| 国产v亚洲v天堂a无码| 久久精品无码一区二区日韩av| 色综合 图片区 小说区| 无码三级av电影在线观看| 亚洲成av人片天堂网| 国产伦理一区二区| 国模欢欢炮交啪啪150| 日日做夜狠狠爱欧美黑人| 亚洲精品tv久久久久久久久j| 欧美日韩精品一区二区三区高清视频 | 日本在线高清不卡免费播放| 精品久久国产综合婷婷五月| 午夜免费啪视频观看视频| 亚洲国产精品尤物yw在线观看| 日日碰狠狠躁久久躁蜜桃| 亚洲三区在线观看内射后入| 亚洲国产成av人天堂无码| 国产剧情无码播放在线看| 亲嘴扒胸摸屁股激烈网站| 国产精品交换| 青青青草国产线观| 国产精品久久久久电影网| 浴室人妻的情欲hd三级国产| 凸凹人妻人人澡人人添| 久久香综合精品久久伊人| 国内偷窥一区二区三区视频| 无码精品黑人一区二区三区| 特大巨黑吊xxxx高潮| 日本熟妇色xxxxxhd| 欧美日韩人妻精品一区二区在线| 亚洲人成图片小说网站| 综合无码一区二区三区|