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  4. Recombinant Human RAD9, RAD1, HUS1-interacting nuclear orphan protein (RHINO)

Recombinant Human RAD9, RAD1, HUS1-interacting nuclear orphan protein (RHINO)

  • 中文名稱：
    人RHNO1重組蛋白
  • 貨號：
    CSB-YP863112HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RHNO1重組蛋白
  • 貨號：
    CSB-EP863112HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RHNO1重組蛋白
  • 貨號：
    CSB-EP863112HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RHNO1重組蛋白
  • 貨號：
    CSB-BP863112HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RHNO1重組蛋白
  • 貨號：
    CSB-MP863112HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RHNO1
  • Uniprot No.：
  • 別名：
    RHNO1; C12orf32; RHINO; HKMT1188; RAD9; HUS1; RAD1-interacting nuclear orphan protein 1; RAD9; RAD1; HUS1-interacting nuclear orphan protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-238
  • 氨基酸序列
    MPPRKKRRQP SQKAPLLFHQ QPLEGPKHSC ASTQLPITHT RQVPSKPIDH STITSWVSPD FDTAAGSLFP AYQKHQNRAR HSSRKPTTSK FPHLTFESPQ SSSSETLGIP LIRECPSESE KDVSRRPLVP VLSPQSCGNM SVQALQSLPY VFIPPDIQTP ESSSVKEELI PQDQKENSLL SCTLHTGTPN SPEPGPVLVK DTPEDKYGIK VTWRRRQHLL AYLRERGKLS RSQFLVKS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation.
  • 基因功能參考文獻：
    1. Knockdown of RHINO in human cells partially abrogated ATR-Chk1 kinase signaling following UV irradiation but did not impact the loading of Rad9-Hus1-Rad1 complex on chromatin or the association of Rad9-Hus1-Rad1 complex with TopBP1. PMID: 25602520
    2. Germline variation in the RHINO gene is unlikely to influence inherited susceptibility to breast cancer. PMID: 24562772
    3. We suggest that RHINO functions together with the 9-1-1 complex and TopBP1 to fully activate ATR (ataxia telangiectasia and Rad3-related. PMID: 21659603
    4. Identified C12orf32 to be significantly up-regulated in the great majority of clinical breast cancer specimens. PMID: 20811708
  • 亞細胞定位：
    Nucleus. Chromosome. Note=Localizes to sites of DNA damage in a H2AX-independent manner.
  • 組織特異性：
    Weakly expressed in testis, prostate, ovary, thymus and small intestine. Expressed strongly in breast cancer cells.
  • 數據庫鏈接：

    HGNC: 28206

    OMIM: 614085

    KEGG: hsa:83695

    STRING: 9606.ENSP00000438590

    UniGene: Hs.198853



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