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  4. Recombinant Human RAC-gamma serine/threonine-protein kinase (AKT3 PKBG)

Recombinant Human RAC-gamma serine/threonine-protein kinase (AKT3 PKBG)

  • 中文名稱：
  • 貨號：
    CSB-YP001556HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP001556HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP001556HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-BP001556HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-MP001556HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    RAC-gamma serine/threonine-protein kinase; EC 2.7.11.1; Protein kinase Akt-3; Protein kinase B gamma; PKB gamma; RAC-PK-gamma; STK-2; AKT3 PKBG
  • 種屬：
    Homo sapiens (Human)
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
  • 基因功能參考文獻：
    1. The authors have found that overexpression of RIZ1 in HEK293 cells reduced the expression of Akt3 protein. PMID: 29367689
    2. Akt3 isoform expression in triple negative breast cancer.AKT3 splice variant lacking serine-472 phosphorylation site promotes apoptosis and suppresses mammary tumorigenesis. PMID: 29038347
    3. FEZF1-AS1 promoted multiple myeloma cells proliferation through regulating miR-610/Akt3 axis. PMID: 29864963
    4. these results suggested that this newly identified miR497/AKT3 signaling pathway may contribute to papillary thyroid cancer (PTC)occurrence and progression. These findings provide novel potential therapeutic targets for the therapy of PTC PMID: 28849051
    5. miR-30a-3p may be a promising biomarker for the early screening of high-risk populations and early diagnosis of Lung adenocarcinoma (LUAD). Our studies provide insights into identifying novel potential biomarkers for diagnosis and prognosis of LUAD PMID: 28791371
    6. these findings illustrated that cir-ZNF609 took part in the onset of HSCR through the crosstalk with AKT3 by competing for shared miR-150-5p. PMID: 27903978
    7. Results found that TR4 promotes the AKT3 expression through transcriptional regulation to drive the EMT phenotype and enhance the seminoma cell proliferation and invasion. PMID: 29197138
    8. Akt1-Akt3 activity (according to Thr308 phosphorylation) is not associated with proliferative processes in the tumor tissue of the thyroid. PMID: 29235817
    9. The results of this study indicated AKT isoforms have different roles and downstream substrates in glioblastoma. and they indicate AKT3 delays tumor progression. PMID: 27422127
    10. Report frequency of genetic variation in Akt3 and discuss link to disease. PMID: 28931550
    11. AKT3 Splice Variants are associated with HPV-Positive Oropharyngeal Cancers. PMID: 28733453
    12. Results show that AKT3 influences outcome of pneumococcal meningitis in human patients; validated the findings in a mouse experimental pneumococcal meningitis model. PMID: 27193124
    13. High AKT3 expression is associated with triple-negative breast cancer. PMID: 28160548
    14. This study showed that activating mutations of AKT3 are associated with a much broader spectrum of developmental brain disorders in children, with several clinical phenotypes determined partially by the type of mutation and level of mosaicism. PMID: 28969385
    15. MiR-511-3p may serve as a prognostic factor and tumor suppressor in prostate cancer, very likely through inverse regulation of its downstream target gene of AKT3. PMID: 28624527
    16. Studies found AKT3 to be important in coordinating mitochondrial biogenesis with growth factor-induced increase in cellular energy demands. This isoform also plays an important role in platelet activation and thrombosis. [review] PMID: 26953242
    17. miR-29b prevents angiogenesis/tumorigenesis in breast cancer cell by targeting Akt3 and inducing VEGF and C-myc arrest in breast cancer cells. PMID: 28365400
    18. AKT3 expression is markedly upregulated in AKT inhibitor-resistant cells. Induction of AKT3 is regulated epigenetically by the bromodomain and extra terminal domain proteins. Importantly, knockdown of AKT3, but not AKT1 or AKT2, in resistant cells restores sensitivity to MK2206. PMID: 27297869
    19. miR-15b-5p is a critical regulator of human EC proliferation and migration by targeting the AKT3 pathway. PMID: 28254819
    20. Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1/Cdc42 pathway. PMID: 28389565
    21. partial co-localization of AKT3 with AURKB was observed during anaphase. Overall, this study suggests that AKT3 could repress the antiproliferative effects of AURKi, with a novel activity particularly suppressing the aneuploidy induction. PMID: 28028179
    22. A C119S Akt3 mutant was hypomorphic for all downstream phenotypes shown by wild-type Akt3. This study documents isozyme-specific and chemical redox signal-personalized physiological responses. PMID: 28114274
    23. the mitochondrial oxygen consumption rate was significantly reduced in Akt3-knockdown cancer cell lines PMID: 26972278
    24. our findings indicate that the expression levels of P-GP, MYC, caspase-8, and AKT3 are candidate biomarkers of cell sensitivity to PLKis. PMID: 27699933
    25. miR-29a could act as a tumor suppressor in PTC by targeting AKT3 and that miR-29a may potentially serve as an anti-tumor agent in the treatment of papillary thyroid carcinoma. PMID: 26482618
    26. showed that miR-20b was down-regulated in the retina and retinal endothelial cells in diabetic rats, with a correlated up-regulation of VEGF and AKT3 PMID: 27421659
    27. The siRNA-induced AKT3 and PI3KCA mRNA knockdown. PMID: 26902608
    28. Bioinformatics analysis further revealed cyclin D2 (CCND2) and AKT3, putative tumor promoters, as potential targets of miR610. Data from reporter assays showed that miR610 directly binds to the 3'untranslated PMID: 26782072
    29. Data show that elevated expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs), Akt3 protein, and tumor suppressor protein p53 (p53) in ovarian serous adenocarcinoma tissues are an indication of more advanced disease and worse prognosis. PMID: 27629740
    30. Perhaps Bcl-2 down-regulation and Akt-3 up-regulation can be linked with survival signals in A549 cell line. We can conclude that Bcl-2 and Akt-3 might be therapeutic targets to inhibit cell proliferation in NSCLC. PMID: 27072269
    31. High AKT3 expression is associated with ovarian cancer. PMID: 26512921
    32. AKT3 has a role in prostate cancer proliferation through regulation of Akt, B-Raf, and TSC1/TSC2 PMID: 26318033
    33. mirn424 has a role in inhibiting Akt3/E2F3 axis and tumor growth in hepatocellular carcinoma PMID: 26315541
    34. Akt1 and Akt2 activated both SREBP-1 and SREBP-2, whereas Akt3 upregulated SREBP-1 to enhance hepatitis C virus translation. PMID: 26855332
    35. Flot-2 exerts a pro-neoplastic role in NPC and is involved in tumor progression and metastasis. Moreover, Flot-2 exerts its role through NF-kappaB and PI3K/Akt3 signaling. PMID: 26206082
    36. Downregulation of AKT3 increases migration and metastasis in triple negative breast cancer cells by upregulating S100A4. PMID: 26741489
    37. These findings indicate that AKT3 upregulation may cause focal malformations of cortical development. PMID: 25091978
    38. These findings suggest a central AKT-FOXG1-reelin signaling pathway in focal malformations of cortical development and support pathway inhibitors as potential treatments or therapies for some forms of focal epilepsy. PMID: 26523971
    39. Data show that both serine/threonine phosphatases PHLPP and dephosphorylated the physiological substrates of Akt1 and Akt3 with similar efficiencies. PMID: 26427440
    40. miR-582-5p regulated the progression of hepatocellular carcinoma through directly inhibiting the expression of CDK1 and AKT3, and indirectly inhibiting the expression of cyclinD1 PMID: 26002580
    41. A 1q44 deletion involving only AKT3 in a boy and his father, is reported. PMID: 25424989
    42. MiR-22 induces EPC senescence by downregulating AKT3 expression. PMID: 25323119
    43. findings identify PI3K/AKT pathway mutations as an important cause of epileptogenic brain malformations and establish megalencephaly, hemimegalencephaly, and focal cortical dysplasia as part of a single pathogenic spectrum. PMID: 25722288
    44. AKT3, PI3KCA, and VEGFR2 silencing reduces the invasiveness of glioblastoma multiforme T98G cells. PMID: 25501707
    45. The individual contribution of each Akt isoform in p120 RasGAP fragment N-mediated cell protection against Fas ligand induced cell death, was investigated. PMID: 25246356
    46. Data suggest that three isoforms of the serine/threonine protein kinase Akt (Akt1, Akt2, Akt3) regulate cell survival, cell growth, cell proliferation, and cell metabolism in breast cancer cells. [REVIEW] PMID: 25233414
    47. Akt3-expressing human glioblastoma cells had enhanced activation of DNA repair proteins, leading to increased DNA repair and subsequent resistance to radiation and temozolomide. PMID: 25737557
    48. The PI3K/AKT/mTOR pathway is distinguishable in SCLC genomic alterations. Therefore, a sequencing-based comprehensive analysis could stratify SCLC patients by potential therapeutic targets. PMID: 25122428
    49. Akt3 is a negative regulator of IGFBP-3 protein. PMID: 24942865
    50. Our study revealed AKT-3 amplification and deletions in 11% (9/82) and 13% (11/82) of triple-negative breast cancers, respectively. PMID: 24138071

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  • 相關疾病：
    Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 (MPPH2)
  • 亞細胞定位：
    Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, RAC subfamily
  • 組織特異性：
    In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
  • 數據庫鏈接：

    HGNC: 393

    OMIM: 611223

    KEGG: hsa:10000

    STRING: 9606.ENSP00000263826

    UniGene: Hs.498292



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