在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Pyridoxine-5'-phosphate oxidase (PNPO)

Recombinant Human Pyridoxine-5'-phosphate oxidase (PNPO)

  • 中文名稱：
    人PNPO重組蛋白
  • 貨號：
    CSB-YP885740HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PNPO重組蛋白
  • 貨號：
    CSB-EP885740HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PNPO重組蛋白
  • 貨號：
    CSB-EP885740HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PNPO重組蛋白
  • 貨號：
    CSB-BP885740HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PNPO重組蛋白
  • 貨號：
    CSB-MP885740HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PNPO
  • Uniprot No.：
  • 別名：
    EC 1.4.3.5; FLJ10535; PDXPO; PNPO; PNPO_HUMAN; Pyridoxal 5' phosphate synthase; pyridoxamine 5' phosphate oxidase; Pyridoxamine phosphate oxidase ; Pyridoxamine-phosphate oxidase; pyridoxine 5' phosphate oxidase; Pyridoxine-5'-phosphate oxidase
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-261
  • 氨基酸序列
    MTCWLRGVTA TFGRPAEWPG YLSHLCGRSA AMDLGPMRKS YRGDREAFEE THLTSLDPVK QFAAWFEEAV QCPDIGEANA MCLATCTRDG KPSARMLLLK GFGKDGFRFF TNFESRKGKE LDSNPFASLV FYWEPLNRQV RVEGPVKKLP EEEAECYFHS RPKSSQIGAV VSHQSSVIPD REYLRKKNEE LEQLYQDQEV PKPKSWGGYV LYPQVMEFWQ GQTNRLHDRI VFRRGLPTGD SPLGPMTHRG EEDWLYERLA P
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
  • 基因功能參考文獻：
    1. TGF-beta1-mediated PNPO expression was at least in part through the upregulation of miR-143-3p in epithelial ovarian cancer. PMID: 29238081
    2. data support a pathogenic role of the c.347G>A (p.Arg116Gln) mutation in PNPO deficiency; the later onset of symptoms and the milder epilepsy phenotype of these expand the disease phenotype PMID: 28818555
    3. Exome sequencing revealed that the patient was compound heterozygous for pathogenic mutations [c.546+1G>A (IVS5+1 G>A) and c.620delG (p.G207VfsX215)] in the PNPO gene. PMID: 26535729
    4. One sequence variant, R116Q, a single nucleotide polymorphism that has been reported in the general population, was found to have an effect on PNPO activity. PMID: 24645144
    5. Challenge to the paradigm of exclusive PLP responsiveness in patients with pyridoxal 5'-phosphate oxidase deficiency and underlines the importance of consecutive testing of pyridoxine and PLP in neonates with antiepileptic drug-resistant seizures. PMID: 24658933
    6. Generalized epilepsies implicates susceptibility genes: CHRM3 at 1q43, VRK2 at 2p16.1, ZEB2 at 2q22.3, SCN1A at 2q24.3 and PNPO at 17q21.32. PMID: 22949513
    7. provide evidence that a single arginine residue of the C terminus of pyridoxal 5'-phosphate synthase is responsible for coordinating co-operativity in this elaborate protein machinery PMID: 21283685
    8. Results describe a combined computer and biochemical approach to characterize human pyridoxine 5'-phosphate oxidase (PNPO). PMID: 15182361
    9. several mutations appear to cause epilepsy PMID: 15772097
    10. We examined 8 single nucleotide polymorphisms (SNPs) in PNPO and its 5'-flanking regions in 359 schizophrenia patients and 582 control subjects. PMID: 17851041
    11. Sequencing of the PNPO gene revealed a novel homozygous nonsense mutationt in exon 3 in the neonatal and infantile seizure. PMID: 18485777
    12. PNP oxidase R229W mutation identified in patients with neonatal epileptic encephalopathy sgnificantly affect the catalytic efficiency of the enzyme. PMID: 19759001

    顯示更多

    收起更多

  • 相關疾病：
    Pyridoxine-5'-phosphate oxidase deficiency (PNPOD)
  • 蛋白家族：
    Pyridoxamine 5'-phosphate oxidase family
  • 數據庫鏈接：

    HGNC: 30260

    OMIM: 603287

    KEGG: hsa:55163

    STRING: 9606.ENSP00000225573

    UniGene: Hs.631742



主站蜘蛛池模板： 内射一区二区精品视频在线观看 | 亚洲欧洲国产综合aⅴ无码| 亚洲欧美中文日韩v在线97| 亚洲一区二区三区| 国产精品爱久久久久久久| 国产麻豆 9l 精品三级站 | 他掀开裙子把舌头伸进去添视频| 亚洲人成网线在线播放va蜜芽| 免费国产又色又爽又黄的网站| 久久五月丁香激情综合| 一本清日本在线视频精品| 久久久久久久综合狠狠综合| 含紧一点h边做边走动免费视频| 亚洲女教师丝祙在线播放| 国产在线高清视频无码| 欧美日韩在线视频一区| 亚洲一区 日韩精品 中文字幕| 欧美极p品少妇的xxxxx| 国产精品极品在线拍| 国产佗精品一区二区三区| 成a人片亚洲日本久久| 日韩一区二区三区射精| 日本又黄又爽又色又刺激的视频 | 色婷婷狠狠97成为人免费| 人妻精品国产一区二区| 少妇性l交大片毛多| av高清无码 在线播放| 亚洲精品伊人久久久大香| 国产精品毛片无遮挡高清| 国产精品久久久久蜜臀| 一本aⅴ高清一区二区三区| 亚洲日韩中文字幕在线播放| 国产精品人人爽人人做我的可爱| 狼人亚洲国内精品自在线| 亚洲国内成人精品网| 日韩人妻一区二区三区蜜桃视频| 久久国产欧美日韩精品图片| 国产成人美女视频网站| 2019日韩中文字幕mv| 亚洲精品动漫免费二区| 国产精品无码a∨果冻传媒|