在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP)

Recombinant Human Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP)

  • 中文名稱：
    Recombinant Human Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(CLPP)
  • 貨號：
    CSB-YP618094HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(CLPP)
  • 貨號：
    CSB-EP618094HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(CLPP)
  • 貨號：
    CSB-EP618094HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(CLPP)
  • 貨號：
    CSB-BP618094HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(CLPP)
  • 貨號：
    CSB-MP618094HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CLPP
  • Uniprot No.：
  • 別名：
    ATP dependent protease ClpAP (E coli) proteolytic subunit; ATP dependent protease ClpAP proteolytic subunit; ATP dependent protease ClpAP proteolytic subunit human; ATP dependent proteolytic subunit homolog (E coli); ATP dependent proteolytic subunit homolog; Caseinolytic peptidase ATP dependent proteolytic subunit homolog; Caseinolytic protease ATP dependent proteolytic subunit E coli; clpP; ClpP caseinolytic peptidase ATP dependent proteolytic subunit; ClpP caseinolytic peptidase ATP dependent proteolytic subunit homolog; CLPP_HUMAN; Endopeptidase Clp; mitochondrial; Putative ATP dependent Clp protease proteolytic subunit mitochondrial; Putative ATP dependent Clp protease proteolytic subunit; Putative ATP-dependent Clp protease proteolytic subunit
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    57-277
  • 氨基酸序列
    PLIP IVVEQTGRGE RAYDIYSRLL RERIVCVMGP IDDSVASLVI AQLLFLQSES NKKPIHMYIN SPGGVVTAGL AIYDTMQYIL NPICTWCVGQ AASMGSLLLA AGTPGMRHSL PNSRIMIHQP SGGARGQATD IAIQAEEIMK LKKQLYNIYA KHTKQSLQVI ESAMERDRYM SPMEAQEFGI LDKVLVHPPQ DGEDEPTLVQ KEPVEAAPAA EPVPAST
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion.
  • 基因功能參考文獻：
    1. Autophagy compensates impaired energy metabolism in CLPXP-deficient Podospora anserina strains and extends healthspan. PMID: 28449241
    2. we demonstrate that a strong mitochondrial cardiomyopathy and diminished respiration due to DARS2 deficiency can be alleviated by the loss of CLPP, leading to an increased de novo synthesis of individual OXPHOS subunits. PMID: 27154400
    3. ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4, LARS2, CLPP and C10orf2 PMID: 26970254
    4. Data suggest that tumors exploit ClpXP-directed proteostasis to maintain mitochondrial bioenergetics, buffer oxidative stress, and enable metastatic competence. PMID: 27389535
    5. Data indicate endopeptidase Clp (ClpP) mutation identified in two patients with Perrault syndrome type 3 in a Turkish family. PMID: 27087618
    6. ClpP proteases from E. coli, S. aureus, and human mitochondria exhibit preferences for certain amino acids in the P1, P2, and P3 positions . PMID: 26606371
    7. Optical trapping to assay single-molecule ClpXP unfolding and translocation of substrates consisting of domains with varying stabilities and sequences; find that ClpXP unfolds most domains by a single pathway, with kinetics that depend on the native fold and structural stability. PMID: 25083874
    8. Deletion of PaClpP, leads to an unexpected healthy phenotype and increased lifespan of the fungal ageing model organism Podospora anserina and This phenotype can be reverted by expression of human ClpP. PMID: 23360988
    9. Perrault syndrome is caused by recessive mutations in CLPP. PMID: 23541340
    10. the N-terminal peptide of ClpP is a structural component of the substrate translocation channel and may play an important functional role as well PMID: 15522782
    11. hClpX can regulate the appearance of hClpP peptidase activity in mitochondria and might affect the nature of the degradation products released during ATP-dependent proteolytic cycles PMID: 16115876
    12. We propose that decreased levels of mitochondrial proteases Lon and ClpP may allow heat shock protein 60 substrate proteins to go through more folding attempts PMID: 18378094

    顯示更多

    收起更多

  • 相關疾病：
    Perrault syndrome 3 (PRLTS3)
  • 亞細胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Peptidase S14 family
  • 組織特異性：
    Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney.
  • 數據庫鏈接：

    HGNC: 2084

    OMIM: 601119

    KEGG: hsa:8192

    STRING: 9606.ENSP00000245816

    UniGene: Hs.515092



主站蜘蛛池模板： 蜜桃av蜜臀av色欲av麻| 国产精品亚洲а∨天堂免下载| 亚洲成a人v欧美综合天堂下载| 亚洲最大的熟女水蜜桃av网站| 老色鬼永久精品网站| 五月婷婷俺也去开心| 99热门精品一区二区三区无码| 隔壁人妻被水电工征服| 一道本在线伊人蕉无码| 97久久综合区小说区图片区| 久久精品成人无码观看不卡| 亚洲日韩a∨无码久| 乱精品一区字幕二区| 卡一卡二卡三免费视频| 欧洲美熟女乱又伦免费视频| 亚洲精品无码不卡av| 欧美性猛交xxxx乱大交3| 免费无码又爽又刺激高潮视频| 国产sm调教折磨视频失禁| 熟妇人妻激情偷爽文| 毛片免费视频观看| 好大好湿好硬顶到了好爽视频| 久久天天躁狠狠躁夜夜躁2012| 日韩人妻ol丝袜av一二区 | 99热这里只有是精品2| 66亚洲一卡2卡新区成片发布| 国产男女无遮挡猛进猛出| 久久久www成人免费看片| 国产一卡二卡四卡无卡免费| 国产高清在线精品一区| 不卡无码av一区二区三区| 亚洲综合天堂一区二区三区| 亚洲一区二区三区av天堂 | 亚洲精品无码国产| 美女网站免费福利视频| 色播久久人人爽人人爽人人片av| 粉嫩虎白女毛片人体| 激情综合婷婷丁香五月蜜桃| 亚洲va国产va天堂va久久| 午夜国产免费视频亚洲| 亚洲欧美日韩另类丝袜一区|