在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CLPP Antibody

CLPP Antibody

  • 中文名稱：
    CLPP兔多克隆抗體
  • 貨號：
    CSB-PA005577GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CLPP
  • 別名：
    ATP dependent protease ClpAP (E coli) proteolytic subunit antibody; ATP dependent protease ClpAP proteolytic subunit antibody; ATP dependent protease ClpAP proteolytic subunit human antibody; ATP dependent proteolytic subunit homolog (E coli) antibody; ATP dependent proteolytic subunit homolog antibody; Caseinolytic peptidase ATP dependent proteolytic subunit homolog antibody; Caseinolytic protease ATP dependent proteolytic subunit E coli antibody; clpP antibody; ClpP caseinolytic peptidase ATP dependent proteolytic subunit antibody; ClpP caseinolytic peptidase ATP dependent proteolytic subunit homolog antibody; CLPP_HUMAN antibody; Endopeptidase Clp antibody; mitochondrial antibody; Putative ATP dependent Clp protease proteolytic subunit mitochondrial antibody; Putative ATP dependent Clp protease proteolytic subunit antibody; Putative ATP-dependent Clp protease proteolytic subunit antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human CLPP
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion.
  • 基因功能參考文獻：
    1. Autophagy compensates impaired energy metabolism in CLPXP-deficient Podospora anserina strains and extends healthspan. PMID: 28449241
    2. we demonstrate that a strong mitochondrial cardiomyopathy and diminished respiration due to DARS2 deficiency can be alleviated by the loss of CLPP, leading to an increased de novo synthesis of individual OXPHOS subunits. PMID: 27154400
    3. ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4, LARS2, CLPP and C10orf2 PMID: 26970254
    4. Data suggest that tumors exploit ClpXP-directed proteostasis to maintain mitochondrial bioenergetics, buffer oxidative stress, and enable metastatic competence. PMID: 27389535
    5. Data indicate endopeptidase Clp (ClpP) mutation identified in two patients with Perrault syndrome type 3 in a Turkish family. PMID: 27087618
    6. ClpP proteases from E. coli, S. aureus, and human mitochondria exhibit preferences for certain amino acids in the P1, P2, and P3 positions . PMID: 26606371
    7. Optical trapping to assay single-molecule ClpXP unfolding and translocation of substrates consisting of domains with varying stabilities and sequences; find that ClpXP unfolds most domains by a single pathway, with kinetics that depend on the native fold and structural stability. PMID: 25083874
    8. Deletion of PaClpP, leads to an unexpected healthy phenotype and increased lifespan of the fungal ageing model organism Podospora anserina and This phenotype can be reverted by expression of human ClpP. PMID: 23360988
    9. Perrault syndrome is caused by recessive mutations in CLPP. PMID: 23541340
    10. the N-terminal peptide of ClpP is a structural component of the substrate translocation channel and may play an important functional role as well PMID: 15522782
    11. hClpX can regulate the appearance of hClpP peptidase activity in mitochondria and might affect the nature of the degradation products released during ATP-dependent proteolytic cycles PMID: 16115876
    12. We propose that decreased levels of mitochondrial proteases Lon and ClpP may allow heat shock protein 60 substrate proteins to go through more folding attempts PMID: 18378094

    顯示更多

    收起更多

  • 相關疾病：
    Perrault syndrome 3 (PRLTS3)
  • 亞細胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Peptidase S14 family
  • 組織特異性：
    Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney.
  • 數據庫鏈接：

    HGNC: 2084

    OMIM: 601119

    KEGG: hsa:8192

    STRING: 9606.ENSP00000245816

    UniGene: Hs.515092



主站蜘蛛池模板： 中国少妇偷人hd| 失禁潮痉挛潮喷av在线无码| 亚洲第一狼人天堂久久| 香蕉在线依人视频| 日本爽爽爽爽爽爽在线观看免 | 欧美三级不卡在线观看| 久久99精品国产麻豆蜜芽| 香蕉久久av一区二区三区app| 影音先锋日日狠狠久久| 日本乱码伦午夜福利在线| 国产乱子影视频上线免费观看| 国产免国产免费| 久久国产成人免费网站777| 日本一卡2卡3卡4卡免费精品| 久久久综合九色合综| 日韩一区二区a片免费观看| 国产精品无码av天天爽| 丰满少妇大叫太大太粗| 婷婷色怡春院| 性欧美丰满熟妇xxxx性仙踪林| 国产无遮挡a片又黄又爽| 亚洲性视频免费视频网站| 欧美饥渴少妇xxxxx性| 无码av免费网站| 欧洲成人一区二区三区| 国产极品白嫩精品| 在线精品亚洲一区二区| 在线 v亚洲 v欧美v 专区| 天天做天天爱夜夜夜爽毛片| 亚洲不卡av不卡一区二区| 国产av福利久久| 国产成人av一区二区在线观看| 国语国产精精品国产国语清晰对话 | 欧美人与动牲交app视频| 亚洲色素色无码专区| 中文无码乱人伦中文视频在线| 亚欧美日韩香蕉在线播放视频| 国产在线欧美日韩精品一区| 亚洲丰满熟妇在线播放电影全集| 国产精品原创巨作av| 国内精品久久久久久久影视|