在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein unc-13 homolog B (UNC13B), partial

  • 中文名稱:
    人UNC13B重組蛋白
  • 貨號:
    CSB-YP025622HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人UNC13B重組蛋白
  • 貨號:
    CSB-EP025622HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人UNC13B重組蛋白
  • 貨號:
    CSB-EP025622HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人UNC13B重組蛋白
  • 貨號:
    CSB-BP025622HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人UNC13B重組蛋白
  • 貨號:
    CSB-MP025622HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    hmunc13; MGC133279; MGC133280; munc13; Munc13-2; Protein unc-13 homolog B; UN13B_HUMAN; unc-13 homolog B (C. elegans); UNC13; Unc13b; Unc13h2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release.
  • 基因功能參考文獻:
    1. A rare missense variation (V1525M) in UNC13B was identified by WES in the multiplex family; this variation was present in five of six affected individuals, but not in eight unaffected individuals or one individual of unknown disease status. Resequencing UNC13B coding regions identified five rare missense variations (T103M, M813T, P1349T, I1362T, and V1525M). PMID: 26990377
    2. The 1-5-8-26 CaM binding motif discovered in Munc13-1 cannot be induced in the classical CaM target skMLCK, indicating unique features of the Munc13 CaM binding motif. PMID: 24854537
    3. Munc13-1 regulates insulin exocytosis PMID: 12871971
    4. MUNC13-4 mutations play a role in the development of familial haemophagocytic lymphohistiocytosis subtype 3 through a defective cytotoxic pathway PMID: 15466010
    5. Data suggest that diacylglycerol-activated hmunc13 serves as an effector of Rab34, mediating lysosome-Golgi trafficking. PMID: 16138900
    6. Data identified a polymorphism in the UNC13B gene associated with nephropathy. UNC13B mediates apopotosis in glomerular cells in the presence of hyperglycemia, an event occurring early in the development of nephropathy. PMID: 18633107
    7. In the bound state, the hydrophobic anchor residue of the calmodulin (CaM)-binding motif in Munc13 contacts two distinct methionine residues in the carboxyl-terminal domain of CaM. PMID: 19492809
    8. mechanistic basis for high glucose-induced protein secretion is through interaction of munc13 and rab34, indicating a potentially critical role for this newly described pathway in the pathogenesis of DN. PMID: 19641095

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Cell junction, synapse.
  • 蛋白家族:
    Unc-13 family
  • 組織特異性:
    Expressed in kidney cortical epithelial cells and brain.
  • 數據庫鏈接:

    HGNC: 12566

    OMIM: 605836

    KEGG: hsa:10497

    STRING: 9606.ENSP00000367756

    UniGene: Hs.493791



主站蜘蛛池模板: 无码中文字幕av免费放| 无码av中文一区二区三区桃花岛| 日日摸日日添日日碰9学生露脸| 永久免费观看黄网视频| 久久久精品中文字幕乱码18| 天天爽夜夜爽人人爽曰| 无码人妻啪啪一区二区| 一本久久a久久免费精品不卡| 久久久精品中文字幕乱码18| 巨胸爆乳美女露双奶头挤奶| 亚洲鲁丝片一区二区三区| 性欧美俄罗斯极品| 国产在线观看免费人成视频| 337p粉嫩大胆色噜噜噜| 久久精品无码一区二区无码| 玩肥熟老妇bbw视频| 伊人久久大香线蕉av成人| 无码日韩人妻精品久久蜜桃| 国产亚洲精品久久久久久打不开| 成人亚洲欧美日韩在线观看| 成人18禁深夜福利网站app免费| 国产艳妇av在线观看果冻传媒| 免费看成人aa片无码视频| 沈阳熟女露脸对白视频| 婷婷色香五月综合激激情| 高清欧美性猛交xxxx黑人猛交| av天堂中av世界中文在线播放 | 男人靠女人免费视频网站| 毛片tv网站无套内射tv网站| 亚洲综合无码一区二区痴汉| 久久99热久久99精品| 老子午夜精品无码不卡 | 国产精品乱子伦xxxx| 国产av无码专区亚汌a√ | 亚洲色无码专区一区| 日韩在线不卡免费视频一区| 阳茎伸入女人阳道视频免费| 色噜噜狠狠色综合网| 狠狠色狠狠色综合日日五| 国产激情精品一区二区三区| 少妇饥渴偷公乱av在线观看涩爱|