在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

UNC13B Antibody, HRP conjugated

  • 中文名稱:
    UNC13B兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA025622LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) UNC13B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    hmunc13 antibody; MGC133279 antibody; MGC133280 antibody; munc13 antibody; Munc13-2 antibody; Protein unc-13 homolog B antibody; UN13B_HUMAN antibody; unc-13 homolog B (C. elegans) antibody; UNC13 antibody; Unc13b antibody; Unc13h2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein unc-13 homolog B protein (12-215AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release.
  • 基因功能參考文獻:
    1. A rare missense variation (V1525M) in UNC13B was identified by WES in the multiplex family; this variation was present in five of six affected individuals, but not in eight unaffected individuals or one individual of unknown disease status. Resequencing UNC13B coding regions identified five rare missense variations (T103M, M813T, P1349T, I1362T, and V1525M). PMID: 26990377
    2. The 1-5-8-26 CaM binding motif discovered in Munc13-1 cannot be induced in the classical CaM target skMLCK, indicating unique features of the Munc13 CaM binding motif. PMID: 24854537
    3. Munc13-1 regulates insulin exocytosis PMID: 12871971
    4. MUNC13-4 mutations play a role in the development of familial haemophagocytic lymphohistiocytosis subtype 3 through a defective cytotoxic pathway PMID: 15466010
    5. Data suggest that diacylglycerol-activated hmunc13 serves as an effector of Rab34, mediating lysosome-Golgi trafficking. PMID: 16138900
    6. Data identified a polymorphism in the UNC13B gene associated with nephropathy. UNC13B mediates apopotosis in glomerular cells in the presence of hyperglycemia, an event occurring early in the development of nephropathy. PMID: 18633107
    7. In the bound state, the hydrophobic anchor residue of the calmodulin (CaM)-binding motif in Munc13 contacts two distinct methionine residues in the carboxyl-terminal domain of CaM. PMID: 19492809
    8. mechanistic basis for high glucose-induced protein secretion is through interaction of munc13 and rab34, indicating a potentially critical role for this newly described pathway in the pathogenesis of DN. PMID: 19641095

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Cell junction, synapse.
  • 蛋白家族:
    Unc-13 family
  • 組織特異性:
    Expressed in kidney cortical epithelial cells and brain.
  • 數據庫鏈接:

    HGNC: 12566

    OMIM: 605836

    KEGG: hsa:10497

    STRING: 9606.ENSP00000367756

    UniGene: Hs.493791



主站蜘蛛池模板: 午夜爱爱爱爱爽爽爽网站| 亚洲 另类 日韩 制服 无码| 捆绑白丝粉色jk震动捧喷白浆| 人妻护士在线波多野结衣| 欧美亚洲日本国产其他| 国产偷窥熟女高潮精品视频| 在线视频免费观看爽爽爽| 国产免费看又黄又大又污的胸| 国产黄在线观看免费观看不卡| 黄网站色成年片在线观看| 色欲天天天无码视频| 极品少妇小泬50pthepon| 摸丰满大乳奶水www免费| 天堂а√中文最新版在线| 国产精品无需播放器在线观看| 18无码粉嫩小泬无套在线观看| 日本特黄特色aaa大片免费| 久久国产劲爆∧v内射-百度| 亚洲国产欧美在线人成人| 亚洲国产精品无码专区成人| 久久精品国产一区二区电影| √最新版天堂资源网在线| 九九热线有精品视频| 青青草在在观免费福利线观看| 少妇激情一区二区三区视频| 午夜成人亚洲理伦片在线观看| 少妇被粗大的猛烈进出图片| 欧美激性欧美激情在线| 亚洲欧美综合在线天堂| 国产成人精品白浆久久69| 日本少妇高潮喷水免费可以看| 亚洲精品久久国产精品| 精品女同一区二区| 性人久久网av| 精品一卡二卡三卡四卡网站| 亚洲熟妇无码av不卡在线播放| 无码国产精品一区二区免费式影视| 国产精品久久久一区二区| 综合久久久久6亚洲综合| 成人三级无码视频在线观看| 亚洲精品无码久久久久久|