在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

UNC13B Antibody, HRP conjugated

  • 中文名稱:
    UNC13B兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA025622LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) UNC13B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    hmunc13 antibody; MGC133279 antibody; MGC133280 antibody; munc13 antibody; Munc13-2 antibody; Protein unc-13 homolog B antibody; UN13B_HUMAN antibody; unc-13 homolog B (C. elegans) antibody; UNC13 antibody; Unc13b antibody; Unc13h2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein unc-13 homolog B protein (12-215AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release.
  • 基因功能參考文獻:
    1. A rare missense variation (V1525M) in UNC13B was identified by WES in the multiplex family; this variation was present in five of six affected individuals, but not in eight unaffected individuals or one individual of unknown disease status. Resequencing UNC13B coding regions identified five rare missense variations (T103M, M813T, P1349T, I1362T, and V1525M). PMID: 26990377
    2. The 1-5-8-26 CaM binding motif discovered in Munc13-1 cannot be induced in the classical CaM target skMLCK, indicating unique features of the Munc13 CaM binding motif. PMID: 24854537
    3. Munc13-1 regulates insulin exocytosis PMID: 12871971
    4. MUNC13-4 mutations play a role in the development of familial haemophagocytic lymphohistiocytosis subtype 3 through a defective cytotoxic pathway PMID: 15466010
    5. Data suggest that diacylglycerol-activated hmunc13 serves as an effector of Rab34, mediating lysosome-Golgi trafficking. PMID: 16138900
    6. Data identified a polymorphism in the UNC13B gene associated with nephropathy. UNC13B mediates apopotosis in glomerular cells in the presence of hyperglycemia, an event occurring early in the development of nephropathy. PMID: 18633107
    7. In the bound state, the hydrophobic anchor residue of the calmodulin (CaM)-binding motif in Munc13 contacts two distinct methionine residues in the carboxyl-terminal domain of CaM. PMID: 19492809
    8. mechanistic basis for high glucose-induced protein secretion is through interaction of munc13 and rab34, indicating a potentially critical role for this newly described pathway in the pathogenesis of DN. PMID: 19641095

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Cell junction, synapse.
  • 蛋白家族:
    Unc-13 family
  • 組織特異性:
    Expressed in kidney cortical epithelial cells and brain.
  • 數據庫鏈接:

    HGNC: 12566

    OMIM: 605836

    KEGG: hsa:10497

    STRING: 9606.ENSP00000367756

    UniGene: Hs.493791



主站蜘蛛池模板: 亚洲中文字幕无码中文字在线| 欧美国产亚洲日韩在线二区| 国产精品女丝袜白丝袜| 狠狠躁天天躁中文字幕| 波多野结衣一区二区三区高清| 国产精品三级国产电影| 久久精品亚洲精品无码白云tv| 人成午夜免费视频无码| 欧美激情a∨在线视频播放| yy111111少妇无码影院| 欧美精品国产aⅴ一区二区在线| 亚洲综合色噜噜狠狠网站超清| 大又大粗又爽又黄少妇毛片免费 | 久久人妻国产精品31| 中文字幕人妻第一区| 成熟妇人a片免费看网站| 男女高潮又爽又黄又无遮挡| 国产综合精品久久丫| 欧美性猛交xxxxx按摩欧美| 亚洲熟妇av一区二区三区| 久久躁狠狠躁夜夜av| 自拍区小说区图片区亚洲| 无码熟妇人妻av在线影片免费 | 国产激情高中生呻吟视频 | 久久大香香蕉国产| 久久精品人人槡人妻人| 免费国产高清毛不卡片基地| 三级无码在钱av无码在钱| 99久久精品国产第一页| 亚洲日韩精品欧美一区二区一| 韩国精品无码少妇在线观看| 尤物蜜芽国产成人精品区| 毛片免费视频在线观看| 欧美成人aaa片一区国产精品| 未满十八勿入av网免费| 一本大道大臿蕉视频无码| ā片在线观看免费观看| 亚洲∧v久久久无码精品| 亚洲国产剧情中文视频在线| 国产日产欧产精品网站| 国精产品999国精产品官网|