在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein transport protein Sec16A (SEC16A), partial

  • 中文名稱:
    人SEC16A重組蛋白
  • 貨號:
    CSB-EP020942HU
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    SEC16A; KIAA0310; SEC16; SEC16L; Protein transport protein Sec16A; SEC16 homolog A; p250
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    26.1kDa
  • 表達區域:
    2121aa-2332aa
  • 氨基酸序列
    AYLPDDKNKSIVWDEKKNQWVNLNEPEEEKKAPPPPPTSMPKTVQAAPPALPGPPGAPVNMYSRRAAGTRARYVDVLNPSGTQRSEPALAPADFVAPLAPLPIPSNLFVPTPDAEEPQLPDGTGREGPAAARGLANPEPAPEPKLSRCSSMSSLSREVSQHFNQAPGDLPAAGGPPSGAMPFYNPAQLAQACATSGSSRLGRIGQRKHLVLN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

問答及客戶評論

 常見問題解答
Q:

I'm looking for Sec16A (human species). Do you have anything available?

A:
Thanks for your inquiry.
1.full-length Sec16A (human species)
Reference: https://www.uniprot.org/uniprot/O15027
Sorry, the full length of the default Isoform 1 has 2179aa, we can't provide the full length, we can only provide the partial.
If you're interested in the partial protein, please let us know which region you're interested in.
Below is one of the partial proteins that we can provide for your reference:
Recombinant Human Protein transport protein Sec16A(SEC16A),partial
CSB-YP020942HU >> Yeast
CSB-EP020942HU >> E.coli
CSB-BP020942HU >> Baculovirus
CSB-MP020942HU >> Mammalian cell
Expression Region: 1943-2154aa; Partial of Isoform 4
Tag information:EP, YP, BP, MP: Tag type will be determined during the manufacturing process.
The expected tag for each expression system is listed as follows: EP, YP, BP, MP: N-terminal 6xHis-tagged
Sequence:

AYLPDDKNKSIVWDEKKNQWVNLNEPEEEKKAPPPPPTSMPKTVQAAPPALPGPPGAPVNMYSRRAAGTRARYVDVLNPSGTQRSEPALAPADFVAPLAPLPIPSNLFVPTPDAEEPQLPDGTGREGPAAARGLANPEPAPEPKLSRCSSMSSLSREVSQHFNQAPGDLPAAGGPPSGAMPFYNPAQLAQACATSGSSRLGRIGQRKHLVLN
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805085/pdf/zmk839.pdf
This literature reports that the SEC16A (1943-2154) can react with Sec23A.

靶點詳情

  • 功能:
    Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Mediates the recruitment of MIA3/TANGO to ERES. Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane. Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183. Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes.
  • 基因功能參考文獻:
    1. these findings highlight a novel function of Sec16A as an essential mediator of endoplasmic reticulum stress-associated unconventional secretion. PMID: 28067262
    2. Sec16A also stabilized the interacting ubiquitin ligase RNF152, which localizes to the lysosome and has structural similarity with RNF183 PMID: 29300766
    3. Mammalian endoplasmic reticulum exit sites are organized by TANGO1 acting as a scaffold, in cooperation with Sec16 for efficient secretion. PMID: 28442536
    4. Results suggest that it is the presence of rare syntenic SEC16A and MAMDC4 deletions that increases susceptibility to axial spondyloarthritis in family members who carry the HLA-B*27 allele. PMID: 25956157
    5. growth factors modulate Sec16 protein levels and dynamics. Sec16 acts as part of a coherent feed-forward loop, which integrates secretion and growth factor signaling. PMID: 25526736
    6. LRRK2 regulates the anterograde endoplasmic reticulum (ER)-Golgi transport through anchoring Sec16A at the endoplasmic reticulum exit sites (ERES). PMID: 25201882
    7. Sec16A remains associated with endoplasmic reticulum exit sites throughout mitosis. PMID: 21045114
    8. Sar1-GTP-dependent assembly of Sec16 on the endoplasmic reticulum(ER) membrane forms an organized scaffold defining ER exit sites PMID: 17005010
    9. Mammalian cells contain two distinct Sec16 homologues: a large protein Sec16L of 2154 aa and a smaller protein Sec16S of 1060 aa. PMID: 17192411
    10. Results suggest that KIAA0310p, a mammalian homologue of yeast Sec16, builds up endoplasmic reticulum (ER) exit sites in cooperation with p125 and plays a role in membrane traffic from the ER. PMID: 17428803
    11. These data are consistent with a model where Sec16 acts as a platform for COPII assembly at endoplasmic reticulum exit sites. PMID: 19638414

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasm, perinuclear region. Cytoplasm, cytosol. Microsome membrane.
  • 蛋白家族:
    SEC16 family
  • 組織特異性:
    Ubiquitous. Expressed at higher levels in the pancreas.
  • 數據庫鏈接:

    HGNC: 29006

    OMIM: 612854

    KEGG: hsa:9919

    STRING: 9606.ENSP00000325827

    UniGene: Hs.522500



主站蜘蛛池模板: 97影院理论午夜伦不卡| 熟妇与小伙子matur老熟妇e| 国产乱视频在线观看| 亚洲精品尤物av在线观看不卡 | 国产乱人伦精品免费| 中文字幕在线免费看线人| 成人啪啪高潮不断观看 | 伊人久久大香线蕉午夜av| 精品国产免费人成电影在线看| 五十路熟女一区二区三区| 7777精品伊人久久久大香线蕉| 国产一卡三卡四卡无卡精品| 国产亚洲日韩欧美另类丝瓜app| 影音先锋每日av色资源站| 日韩精品无码一区二区三区| 真人做受试看120分钟小视频| 亚洲色欲色欲www成人网| 国产偷窥熟妇高潮呻吟| 极品少妇hdxx麻豆hdxx| 久久亚洲道色宗和久久 | 五月天激情国产综合婷婷婷| 巨胸美乳无码人妻视频| 丁香婷婷无码不卡在线| 亚洲国产精品久久久久秋霞小| 亚洲精品天堂成人片av在线播放| 国产xxxx做受性欧美88| 精品无码成人片一区二区| 中国精学生妹品射精久久| 中文成人在线| 国产精品成人永久在线| 国产精品高潮呻吟av久久黄 | 狠狠cao2020高清视频| 亚洲中文无码mv| 日韩少妇内射免费播放18禁裸乳| 欧美丰满妇大ass| 亚洲性色成人av| 放荡的少妇2欧美版| 亚洲妇熟xxxx妇色黄| 扒开双腿猛进入喷水高潮叫声| 久久www免费人成_看片中文| h肉动漫无码无修6080动漫网|