在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SEC16A Antibody

  • 中文名稱:
    SEC16A兔多克隆抗體
  • 貨號:
    CSB-PA080090
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    SEC16A antibody; KIAA0310 antibody; SEC16 antibody; SEC16L antibody; Protein transport protein Sec16A antibody; SEC16 homolog A antibody; p250 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human Sec16A.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Mediates the recruitment of MIA3/TANGO to ERES. Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane. Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183. Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes.
  • 基因功能參考文獻:
    1. these findings highlight a novel function of Sec16A as an essential mediator of endoplasmic reticulum stress-associated unconventional secretion. PMID: 28067262
    2. Sec16A also stabilized the interacting ubiquitin ligase RNF152, which localizes to the lysosome and has structural similarity with RNF183 PMID: 29300766
    3. Mammalian endoplasmic reticulum exit sites are organized by TANGO1 acting as a scaffold, in cooperation with Sec16 for efficient secretion. PMID: 28442536
    4. Results suggest that it is the presence of rare syntenic SEC16A and MAMDC4 deletions that increases susceptibility to axial spondyloarthritis in family members who carry the HLA-B*27 allele. PMID: 25956157
    5. growth factors modulate Sec16 protein levels and dynamics. Sec16 acts as part of a coherent feed-forward loop, which integrates secretion and growth factor signaling. PMID: 25526736
    6. LRRK2 regulates the anterograde endoplasmic reticulum (ER)-Golgi transport through anchoring Sec16A at the endoplasmic reticulum exit sites (ERES). PMID: 25201882
    7. Sec16A remains associated with endoplasmic reticulum exit sites throughout mitosis. PMID: 21045114
    8. Sar1-GTP-dependent assembly of Sec16 on the endoplasmic reticulum(ER) membrane forms an organized scaffold defining ER exit sites PMID: 17005010
    9. Mammalian cells contain two distinct Sec16 homologues: a large protein Sec16L of 2154 aa and a smaller protein Sec16S of 1060 aa. PMID: 17192411
    10. Results suggest that KIAA0310p, a mammalian homologue of yeast Sec16, builds up endoplasmic reticulum (ER) exit sites in cooperation with p125 and plays a role in membrane traffic from the ER. PMID: 17428803
    11. These data are consistent with a model where Sec16 acts as a platform for COPII assembly at endoplasmic reticulum exit sites. PMID: 19638414

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasm, perinuclear region. Cytoplasm, cytosol. Microsome membrane.
  • 蛋白家族:
    SEC16 family
  • 組織特異性:
    Ubiquitous. Expressed at higher levels in the pancreas.
  • 數據庫鏈接:

    HGNC: 29006

    OMIM: 612854

    KEGG: hsa:9919

    STRING: 9606.ENSP00000325827

    UniGene: Hs.522500



主站蜘蛛池模板: 毛片免费视频在线观看| 国产欧美另类久久久精品丝瓜| 亚洲欧美中文字幕高清在线| 欧美群交射精内射颜射潮喷| 欧美日韩一区二区三区视频播放| 在线观看无码不卡av中文| 一区一区三区产品乱码亚洲| 丰满少妇人妻无码| 国产精品白丝喷水在线观看| 自偷自拍亚洲综合精品| 久久ee热这里只有精品| 柠檬福利第一导航在线| 脱了美女内裤猛烈进入gif| 日日碰狠狠躁久久躁2023| 在线|国产精品女主播阳台| 人妻少妇精品久久| 中文字幕无码一区二区免费| 久久五月丁香激情综合| 好男人在在线社区www在线影院| 无码视频一区二区三区在线观看 | 西西4444www大胆无码| 国产suv精品一区二区883| 韩国乱码片免费看| 天堂av成年av影视| 精品国产乱码久久久久久鸭王1| 9re热国产这里只有精品| 亚洲精品卡一卡三卡四卡乱码| 久久人妻少妇嫩草av| 久久久综合亚洲色一区二区三区| 国产黄在线观看免费观看不卡| 欧美大波少妇在厨房被| 一本色道久久综合亚洲精品 | 国产日韩精品欧美一区喷水| 日韩免费一区二区三区高清| 亚洲精品黑牛一区二区三区| 日韩人妻熟女中文字幕a美景之屋| 久久婷婷五月综合色d啪| 中文字幕精品av乱码在线| 国产真实乱对白精彩久久老熟妇女| 丝袜自慰一区二区三区| 人妻aⅴ中文字幕无码|