Recombinant Human Protein phosphatase 1 regulatory subunit 3A (PPP1R3A), partial

中文名稱：

人PPP1R3A重組蛋白
貨號(hào)：

CSB-YP613701HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人PPP1R3A重組蛋白
貨號(hào)：

CSB-EP613701HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人PPP1R3A重組蛋白
貨號(hào)：

CSB-EP613701HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PPP1R3A重組蛋白
貨號(hào)：

CSB-BP613701HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人PPP1R3A重組蛋白
貨號(hào)：

CSB-MP613701HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

PPP1R3A
Uniprot No.：

Q16821
別名：

Glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle; Glycogen associated regulatory subunit of protein phosphatase 1; GM; PP1G; PPP1R3; PPP1R3A; PPR3A_HUMAN; Protein phosphatase 1 glycogen-associated regulatory subunit; Protein phosphatase 1 glycogen-targeting subunit, muscle; Protein phosphatase 1 regulatory subunit 3A; Protein phosphatase 1 regulatory subunit GM; protein phosphatase 1, regulatory (inhibitor) subunit 3A; Protein phosphatase 1, regulatory subunit 3; Protein phosphatase type-1 glycogen targeting subunit; RG1; Serine /threonine specific protein phosphatase; Type 1 protein phosphatase skeletal muscle glycogen targeting subunit
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase.
基因功能參考文獻(xiàn)：
1. Variant in PPP1R3A is associated with type 2 diabetes. PMID: 29948331
2. In the univariate analyses, TP53, PPP1R3A, and KMT2B were significantly more frequently mutated in interval cancers than in screen-detected cancers. PMID: 27587435
3. results demonstrate that hScrib acts as a scaffold to integrate the control of the PP1gamma and ERK signaling pathways and explains how disruption of hScrib localisation can contribute towards the development of human malignancy PMID: 23359326
4. A joint effect between the Asp905 and BMI increases the risk of type 2 diabetes, and Asp905Tyr and ARE polymorphism of PPP1R3 gene are not the major diabetogenic gene variants in Chinese population. PMID: 11793847
5. G(M) promotes glycogen storage and inversely regulates glycogen synthase and glycogen phosphorylase activities, while, specifically, synthase phosphatase activity of G(M)-PP1 is inhibited by glycogen. PMID: 12941760
6. Among the largest cohort of nondiabetic subjects (Caucasian, n = 112), the presence of the deletion allele (ARE-2) was associated with insulin resistance and hyperandrogenemia. PMID: 15181086
7. Inactivation of PPP1R3 gene is associated with tumor progression and metastasis of colorectal cancers PMID: 15870946
8. PPP1R3A C1984DeltaAG (stop codon 668) isthe 1st prevalent mutation that directly impairs glycogen synthesis & decreases glycogen levels in human skeletal muscle. It is present in approximately 1 in 70 UK whites. PMID: 18232732
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相關(guān)疾病：

Diabetes mellitus, non-insulin-dependent (NIDDM)
亞細(xì)胞定位：

Membrane; Single-pass membrane protein.
組織特異性：

Skeletal muscle and heart.
數(shù)據(jù)庫鏈接：

HGNC: 9291

OMIM: 125853

KEGG: hsa:5506

STRING: 9606.ENSP00000284601

UniGene: Hs.458309