在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein mono-ADP-ribosyltransferase PARP10 (PARP10), partial

  • 中文名稱:
    人PARP10重組蛋白
  • 貨號:
    CSB-MP709602HU1
  • 規格:
    ¥2376
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    PARP10
  • Uniprot No.:
  • 別名:
    ADP-ribosyltransferase diphtheria toxin-like 10;ARTD10;Poly [ADP-ribose] polymerase 10;PARP-10
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    Mammalian cell
  • 分子量:
    70.1 kDa
  • 表達區域:
    650-1025aa
  • 氨基酸序列
    LEEEAALQLALHRSLEPQGQVAEQEEAAALRQALTLSLLEQPPLEAEEPPDGGTDGKAQLVVHSAFEQDVEELDRALRAALEVHVQEETVGPWRRTLPAELRARLERCHGVSVALRGDCTILRGFGAHPARAARHLVALLAGPWDQSLAFPLAASGPTLAGQTLKGPWNNLERLAENTGEFQEVVRAFYDTLDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAHGFNRSFCGRNATVYGKGVYFARRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGLRAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHVPRASPDDPSGLPGRSPDT
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal hFc1-tagged and C-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA.
  • 基因功能參考文獻:
    1. PARP10 expression decreased upon fasting, a condition that is characterized by increases in mitochondrial biogenesis. Finally, lower PARP10 expression is associated with increased fatty acid oxidation PMID: 29293500
    2. ARTD10 plays roles in immunity, metabolism ,apoptosis and DNA damage repair. [review] PMID: 24878761
    3. PARP10 binding to PCNA is required for translesion DNA synthesis. PMID: 24695737
    4. study results show that the interaction between PARP10 and NS1 of H5N1 avian influenza virus can change cell cycle, and PARP10 can affect virus replication PMID: 22176891
    5. novel PARP enzyme involved in the control of cell proliferation PMID: 15674325
    6. Overexpression of PARP10 results in loss of cell viability, although down-expression by short hairpin RNA leads to delayed G1 progression and concomitant cell death. PMID: 16455663
    7. alternative catalytic mechanism for PARP10 compared to PARP1 in which the acidic target residue of the substrate functionally substitutes for the catalytic glutamate by using substrate-assisted catalysis to transfer ADP-ribose PMID: 18851833

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleolus. Cytoplasm.
  • 組織特異性:
    Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon.
  • 數據庫鏈接:

    HGNC: 25895

    OMIM: 609564

    KEGG: hsa:84875

    STRING: 9606.ENSP00000325618

    UniGene: Hs.348609



主站蜘蛛池模板: 人妻少妇久久中文字幕| 日日噜噜夜夜狠狠视频| 亚洲国产高清在线一区二区三区| 国产精品色拉拉| 白丝爆浆18禁一区二区三区| 亚洲精品成人区在线观看| 欧美大肥婆大肥bbbbb| 欧美激情猛片xxxⅹ大3| 国产亚洲久久久久久久| 日本少妇毛茸茸高潮| 色婷婷久久久swag精品| 亚洲欧美自拍制服另类图区| 18禁成人黄网站免费观看久久| 熟女人妻aⅴ一区二区三区60路| 国产精品久久久久影院| 日韩精品国产另类专区| 国产成人av 综合 亚洲| 国产精品久久久久久无毒不卡| 忘忧草社区中文字幕www| 男女裸交无遮挡啪啪激情试看| 亚洲国产精品久久久久久久| 男女猛烈无遮挡免费视频 | 成年美女黄网站色大片免费看| 99久久久无码国产精品免费| 在线观看国产日韩亚洲中 | 2020久久香蕉国产线看观看| 无码精品国产一区二区免费| 久久国产人妻一区二区| 少妇系列之白嫩人妻| 中文中幕a在线| 国产精品亚洲а∨天堂| 肥臀熟女一区二区三区| 国产sm主人调教女m视频| 亚洲国产欧美不卡在线观看| 国产亚洲综合区成人国产系列| 欧美精品videosex性欧美| 亚洲日韩片无码中文字幕| 欧美日韩精品一区二区在线视频| 国内a∨免费播放| 日韩中文高清在线专区| 国产高潮流白浆视频|