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  4. Recombinant Human Protein dpy-19 homolog 2 (DPY19L2), partial

Recombinant Human Protein dpy-19 homolog 2 (DPY19L2), partial

  • 中文名稱：
    人DPY19L2重組蛋白
  • 貨號：
    CSB-YP757514HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人DPY19L2重組蛋白
  • 貨號：
    CSB-EP757514HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人DPY19L2重組蛋白
  • 貨號：
    CSB-EP757514HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人DPY19L2重組蛋白
  • 貨號：
    CSB-BP757514HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人DPY19L2重組蛋白
  • 貨號：
    CSB-MP757514HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    DPY19L2
  • Uniprot No.：
  • 別名：
    DPY19L2; UNQ3127/PRO10284; Probable C-mannosyltransferase DPY19L2; EC 2.4.1.-; Dpy-19-like protein 2; Protein dpy-19 homolog 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation.
  • 基因功能參考文獻：
    1. Low PLCZ1 expression is associated with globozoospermia with DPY19L2 deletion. PMID: 29339016
    2. provide new evidence, on the one hand, for a severe lack of maturation of the NL, and on the other hand, for dramatic modifications in the location of chromatin-related NL partners in DPY19L2-deleted spermatozoa PMID: 28882431
    3. Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2. PMID: 27779748
    4. Among Tunisian patients with globozoospermia, 8 DPY19L2 haplotypes were found. 61.1% were homozygous for a DPY19L2 deletion. A new splice-site mutation at the junction exon-intron 16 [c.1579_1580+4delAGGTAAinsTCAT] was found in 1 patient. PMID: 26516168
    5. The DPY19L2 mutations are the major cause of globozoospermia. PMID: 23512994
    6. Analysis of public databases at the DPY19L2 locus paradoxically revealed that, in the general population, duplications were approximately three times as frequent as deletions. PMID: 23555282
    7. DPY19L2 is the major gene responsible for globozoospermia and enlarges the spectrum of possible mutations in the gene. PMID: 22653751
    8. identification of DPY19L2 deletions and point mutations in European patients shows that globozoospemia caused by a molecular defect of DPY19L2 can be expected in individuals from any ethnic background PMID: 22627659
    9. Patients with globozoospermia have a homozygous deletion of DPY19L2. PMID: 21397064
    10. The relocation of the gene DPY19L2 within a set of low copy repeats. PMID: 16526957

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  • 相關疾病：
    Spermatogenic failure 9 (SPGF9)
  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Dpy-19 family
  • 組織特異性：
    Widely expressed with high expression in testis. Not detectable in ejaculated sperm (at protein level).
  • 數據庫鏈接：

    HGNC: 19414

    OMIM: 613893

    KEGG: hsa:283417

    STRING: 9606.ENSP00000315988

    UniGene: Hs.533644



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