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DPY19L2 Antibody, Biotin conjugated

  • 中文名稱:
    DPY19L2兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA757514LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DPY19L2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    DPY19L2
  • 別名:
    DPY19L2 antibody; UNQ3127/PRO10284 antibody; Probable C-mannosyltransferase DPY19L2 antibody; EC 2.4.1.- antibody; Dpy-19-like protein 2 antibody; Protein dpy-19 homolog 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Probable C-mannosyltransferase DPY19L2 protein (599-749AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation.
  • 基因功能參考文獻:
    1. Low PLCZ1 expression is associated with globozoospermia with DPY19L2 deletion. PMID: 29339016
    2. provide new evidence, on the one hand, for a severe lack of maturation of the NL, and on the other hand, for dramatic modifications in the location of chromatin-related NL partners in DPY19L2-deleted spermatozoa PMID: 28882431
    3. Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2. PMID: 27779748
    4. Among Tunisian patients with globozoospermia, 8 DPY19L2 haplotypes were found. 61.1% were homozygous for a DPY19L2 deletion. A new splice-site mutation at the junction exon-intron 16 [c.1579_1580+4delAGGTAAinsTCAT] was found in 1 patient. PMID: 26516168
    5. The DPY19L2 mutations are the major cause of globozoospermia. PMID: 23512994
    6. Analysis of public databases at the DPY19L2 locus paradoxically revealed that, in the general population, duplications were approximately three times as frequent as deletions. PMID: 23555282
    7. DPY19L2 is the major gene responsible for globozoospermia and enlarges the spectrum of possible mutations in the gene. PMID: 22653751
    8. identification of DPY19L2 deletions and point mutations in European patients shows that globozoospemia caused by a molecular defect of DPY19L2 can be expected in individuals from any ethnic background PMID: 22627659
    9. Patients with globozoospermia have a homozygous deletion of DPY19L2. PMID: 21397064
    10. The relocation of the gene DPY19L2 within a set of low copy repeats. PMID: 16526957

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  • 相關疾病:
    Spermatogenic failure 9 (SPGF9)
  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Dpy-19 family
  • 組織特異性:
    Widely expressed with high expression in testis. Not detectable in ejaculated sperm (at protein level).
  • 數據庫鏈接:

    HGNC: 19414

    OMIM: 613893

    KEGG: hsa:283417

    STRING: 9606.ENSP00000315988

    UniGene: Hs.533644



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