Recombinant Human Protein downstream neighbor of Son (DONSON)

中文名稱：

人DONSON重組蛋白
貨號：

CSB-YP868359HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人DONSON重組蛋白
貨號：

CSB-EP868359HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人DONSON重組蛋白
貨號：

CSB-EP868359HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人DONSON重組蛋白
貨號：

CSB-BP868359HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人DONSON重組蛋白
貨號：

CSB-MP868359HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

DONSON
Uniprot No.：

Q9NYP3
別名：

DONSON; C21orf60Protein downstream neighbor of Son; B17
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-566
氨基酸序列

MALSVPGYSP GFRKPPEVVR LRRKRARSRG AAASPPRELT EPAARRAALV AGLPLRPFPA AGGRGGGSGG GPAAARRNPF ARLDNRPRVA AEPPDGPARE QPEAPVPFLD SNQENDLLWE EKFPERTTVT ELPQTSHVSF SEPDIPSSKS TELPVDWSIK TRLLFTSSQP FTWADHLKAQ EEAQGLVQHC RATEVTLPKS IQDPKLSSEL RCTFQQSLIY WLHPALSWLP LFPRIGADRK MAGKTSPWSN DATLQHVLMS DWSVSFTSLY NLLKTKLCPY FYVCTYQFTV LFRAAGLAGS DLITALISPT TRGLREAMRN EGIEFSLPLI KESGHKKETA SGTSLGYGEE QAISDEDEEE SFSWLEEMGV QDKIKKPDIL SIKLRKEKHE VQMDHRPESV VLVKGINTFT LLNFLINSKS LVATSGPQAG LPPTLLSPVA FRGATMQMLK ARSVNVKTQA LSGYRDQFSL EITGPIMPHS LHSLTMLLKS SQSGSFSAVL YPHEPTAVFN ICLQMDKVLD MEVVHKELTN CGLHPNTLEQ LSQIPLLGKS SLRNVVLRDY IYNWRS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability.
基因功能參考文獻：
1. Aberrant splicing and a noncoding mutation in DONSON gene is the cause of microcephaly-micromelia syndrome PMID: 28630177
相關疾病：

Microcephaly-micromelia syndrome (MIMIS); Microcephaly, short stature, and limb abnormalities (MISSLA)
亞細胞定位：

Nucleus.
蛋白家族：

DONSON family
組織特異性：

Expressed in the brain, with higher levels in prenatal compared to adult brain.
數據庫鏈接：

HGNC: 2993

OMIM: 251230

KEGG: hsa:29980

STRING: 9606.ENSP00000307143

UniGene: Hs.436341