在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Protein-arginine deiminase type-2 (PADI2)

Recombinant Human Protein-arginine deiminase type-2 (PADI2)

  • 中文名稱：
    Recombinant Human Protein-arginine deiminase type-2 (PADI2)
  • 貨號(hào)：
    CSB-MP896493HUd7
  • 規(guī)格：
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 別名：
    PAD-H19;Peptidylarginine deiminase II;Protein-arginine deiminase type II
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Full Length
  • 來源：
    Mammalian cell
  • 分子量：
    77.1 kDa
  • 表達(dá)區(qū)域：
    1-665aa
  • 氨基酸序列
    MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEEVATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISLDVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKDMSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRRKLYHVVKYTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVNGKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVPIPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQENLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    C-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the deimination of arginine residues of proteins.
  • 基因功能參考文獻(xiàn)：
    1. the mRNA expression of PADI2, PADI4 and Sp1 is upregulated in rheumatoid arthritis bone marrow CD34+ cells independently of the systemic inflammation or treatment regimen. PMID: 29148420
    2. These data suggest that overexpression of the human PAD2 transgene in the epidermis of transgenic mice increases the malignant conversion rate of benign tumors by promoting an inflammatory microenvironment. PMID: 28766045
    3. Brain gene expression of PADI2, ZNF385A, PSD2, and A2ML1 and DNA methylation dysregulations are implicated in the alteration of brain tissue properties associated with late-life cognitive decline above and beyond the influence of common neuropathologic conditions. PMID: 29084334
    4. Peptidyl arginine deiminase 2 (PADI2) is required for activation of androgen receptor (AR) signaling under androgen-deprived condition. PMID: 28819028
    5. Data suggest that protein-arginine deiminase 2 (PADI2) suppresses the proliferation of colonic epithelial cells through catalysis of protein citrullination, and that downregulation of PADI2 expression might therefore contribute to colon carcinogenesis. PMID: 28403548
    6. Downregulation of PADI2 is an early event in the pathogenesis of colorectal cancer associated with poor prognosis and points toward a possible role of citrullination in modulating tumor cells and their microenvironment. PMID: 27280713
    7. Multiple proteins citrullinated by hypoxia-induced PADs were identified. In addition, the extracellular domain of vascular endothelial growth factor receptor 2 was citrullinated by human PAD2 in vitro. CONCLUSION: Our data may contribute to understanding of pathophysiology of malignant gliomas from the aspects of protein citrullination. PMID: 27818200
    8. Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its binding to the proteasome and decelerates its degradation by the proteasome in mammalian cells. Potential anticancer drug tetrazole analogue of chloramidine 2, at concentrations greater than 1 microM inhibits the enzymatic activity of PAD in vitro. PMID: 27599511
    9. this study shows that a miR-4728 downregulates PADI2, a novel rheumatoid arthritis risk gene PMID: 26927695
    10. We identified the presence of PADI3 mRNA expression in synovial tissue and PADI2 and PADI4 mRNA expressions in fibroblast-like synoviocytes from patients with rheumatoid arthritis. PMID: 26255191
    11. Protein arginine deiminase 2 binds six calcium ions in an ordered fashion. PMID: 25621824
    12. PAD2 activity was significantly higher in cell-free synovial fluid of rheumatoid arthritis patients compared to osteoarthritis patients. PMID: 26245941
    13. PAD2 activity was detected in synovial fluid samples from patients with rheumatoid arthritis. PMID: 25475141
    14. Report increased levels of extracellular PAD2 in the lungs of smokers. PMID: 25897949
    15. PADI2 and vimentin participate in the apoptotic mechanisms of activated T lymphocytes. PMID: 24850148
    16. these studies provide the first genetic evidence that PAD2 functions as an oncogene and suggest that PAD2 may promote tumor progression by enhancing inflammation within the tumor microenvironment. PMID: 25213324
    17. PAD2 appears to use a substrate-assisted mechanism of catalysis in which the positively charged substrate guanidinium depresses the pKa of the nucleophilic cysteine PMID: 24989433
    18. Data suggest peptidylarginine deiminase 2 (PAD2) as a possible biomarker in various inflammatory diseases. PMID: 24384061
    19. PAD2 and PAD4 have distinct substrate specificities. PMID: 24594197
    20. These findings suggest that PAD2 and citrullinated proteins may play a key role in the brain pathology of prion diseases. [review] PMID: 23022892
    21. Our observations show increased levels of protein deimination but not PAD2 in age related macular degeneration retinas and retinal pigment epithelium suggesting reduced rate of turnover of deiminated proteins. PMID: 23562679
    22. PAD2 binds directly to the promoters of the PTN and MAGEA12 genes and that the likely mechanism by which PAD2 regulates expression of these genes is via citrullination of arginine residues 2-8-17 on histone H3 tails. PMID: 22911765
    23. Contact between stimulated T cells and monocyte-macrophages or cytokine-activated monocyte-macrophages constitutes a highly likely source of PAD2 and PAD4, which are observed in inflamed synovial tissues. PMID: 22614825
    24. Normal human and canine mammary epithelium showed strong cytoplasmic and nuclear expression of PAD2, but there was reduced PAD2 expression in mammary carcinomas from both species. PMID: 22520816
    25. 17beta-estradiol stimulation induces the recruitment of PAD2 to target promoters by ERalpha, whereby PAD2 then citrullinates H3R26, which leads to local chromatin decondensation and transcriptional activation. PMID: 22853951
    26. Defective regulation of PAD2 in the periphery blood, without the immunological shelter of the blood-brain barrier, may contribute to the development of the autoimmune responses in MS. PMID: 21878453
    27. This is the first report demonstrating that like in primary open angle glaucoma, normal tension glaucoma also possesses elevated levels of both PAD2 and protein-bound citrulline. PMID: 20806090
    28. PAD2 activation and aberrant citrullinated proteins could play a role in pathogenesis and have value as a marker for the postmortem classification of neurodegenerative diseases. PMID: 20013286
    29. PADI2 does not contribute to genetic susceptibility to schizophrenia. PMID: 19478818
    30. PAD2 is expressed in human monocytic leukaemia THP-1 cells during differentiation into macrophages PMID: 19564157
    31. molecular cloning and gene organization; expressed by all the living epidermal layers, suggesting that PAD type II is functionally important during terminal differentiation of epidermal keratinocytes PMID: 12392711
    32. first report to demonstrate a measurable response in the amounts of peptidylarginine deiminase type II mRNA, protein and activity in human astrocytes by prolonged hypoxic exposure PMID: 15555572
    33. hPADI2 and hPADI4 have different roles under physiological and pathological conditions PMID: 15629448
    34. The amount of peptidyl arginine deiminase type II enzyme and citrullinated myelin basic protein was increased in multiple sclerosis PMID: 17469138
    35. PAD-2 & PAD-4 are only isotypes expressed in synovial tissue in rheumatoid arthritis & other arthritides; inflammatory cells are major source, but PAD-4 also comes from hyperplastic synoviocytes; both isotypes probably involved in citrullination of fibrin PMID: 17968929
    36. These data provide new structure-function dimensions for chemokines in leukocyte mobilization, disclosing an anti-inflammatory role for PAD. PMID: 18645041
    37. The citrullinating enzyme PAD-4 was detected in synovial fluid from patients with rheumatoid arthritis and spondylarthritides. PMID: 18668562
    38. Results describe the in vitro kinetic properties of the human peptidylarginine deiminase isoform 2 (hPAD2), and explore the putative inhibitory action of the methyl ester side chain of paclitaxel. PMID: 18923545

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein arginine deiminase family
  • 組織特異性：
    Detected in keratinocytes in epidermis (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18341

    OMIM: 607935

    KEGG: hsa:11240

    STRING: 9606.ENSP00000364635

    UniGene: Hs.33455



主站蜘蛛池模板： 国产98色在线 | 国| 99c视频色欲在线| 日本污ww视频网站| www国产精品内射熟女| 国产精品亚洲专区无码牛牛 | 1313午夜精品理论片| 免费看小12萝裸体视频国产| 欧美成人无码a区视频在线观看| 国产精品av在线| 黑人粗长大战亚洲女| 国产成人卡2卡3卡4乱码| 久久久肥妇熟女ⅹxxx毛片| 九九视频免费精品视频| 中文字幕日韩一区二区三区不卡| 人妻熟女一区二区aⅴ向井蓝| 午夜福利在线永久视频| 国产高清乱码又大又圆| 国产传媒精品1区2区3区| 国产精品未满十八禁止观看| 丰满人妻熟妇乱又伦精品软件| yy6080久久伦理一区二区| 久久亚洲中文无码咪咪爱| 午夜免费啪视频观看视频| 亚洲精品日本久久一区二区三区| 99精品国产在热久久无码| 极品美女在线观看免费直播| 2021少妇久久久久久久久久| 性生交片免费无码看人| 伊人久久大香线蕉综合网站| 精品无码久久久久国产手机版| 国产女人天天春夜夜春| 无码爆乳护士让我爽| 色 亚洲 日韩 国产 综合| 久久久国产成人一区二区| 偷窥国产亚洲免费视频| 大香网伊人久久综合网2018| 国产jk精品白丝av在线观看| 99久久国产宗和精品1上映| 国产高清乱理伦片| 欧美午夜成人片在线观看| 国产精品久久久久野外|