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  4. Recombinant Human Protein Wnt-10b (WNT10B)

Recombinant Human Protein Wnt-10b (WNT10B)

  • 中文名稱：
    人WNT10B重組蛋白
  • 貨號：
    CSB-YP026130HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人WNT10B重組蛋白
  • 貨號：
    CSB-EP026130HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人WNT10B重組蛋白
  • 貨號：
    CSB-BP026130HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人WNT10B重組蛋白
  • 貨號：
    CSB-MP026130HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Protein Wnt-10b; Protein Wnt-12; SHFM6; wingless type MMTV integration site family; member 10B; WN10B_HUMAN; WNT 10B protein; WNT 12; Wnt10b; wnt12
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    29-389
  • 氨基酸序列
    NE ILGLKLPGEP PLTANTVCLT LSGLSKRQLG LCLRNPDVTA SALQGLHIAV HECQHQLRDQ RWNCSALEGG GRLPHHSAIL KRGFRESAFS FSMLAAGVMH AVATACSLGK LVSCGCGWKG SGEQDRLRAK LLQLQALSRG KSFPHSLPSP GPGSSPSPGP QDTWEWGGCN HDMDFGEKFS RDFLDSREAP RDIQARMRIH NNRVGRQVVT ENLKRKCKCH GTSGSCQFKT CWRAAPEFRA VGAALRERLG RAIFIDTHNR NSGAFQPRLR PRRLSGELVY FEKSPDFCER DPTMGSPGTR GRACNKTSRL LDGCGSLCCG RGHNVLRQTR VERCHCRFHW CCYVLCDECK VTEWVNVCK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.
  • 基因功能參考文獻：
    1. Treatment of secondary hyperparathyroidism with calcitriol improved the bone anabolism by inhibiting osteoclasts and promoting osteoblasts that might be achieved by increasing the Wnt 10b level. PMID: 30149605
    2. We report an Indian girl with split-hand/foot malformation (SHFM), sparse hair, and interrupted eyebrows, who carries a novel homozygous deletion c.695_697delACA in WNT10B. The variant is deduced to cause an in-frame deletion of Asn residue 232 (p.Asn232del). PMID: 29427788
    3. Wnt10b is involved in forskolin/hCG-mediated BeWo cell fusion via beta-catenin/GCMa/syncytin pathway, which may also involve activation of PKA PMID: 28370659
    4. These results present the first evidence for a recurrent rearrangement promoted by a mobile ht-WNT10B oncogene, as a relevant mechanism for Wnt involvement in human cancer. PMID: 27853307
    5. High expression of WNT10B is associated with epithelial-mesenchymal transition and invasion of pancreatic cancer. PMID: 28586066
    6. this study provides novel insight into the mechanism of action of parathyroid hormone on human periodontal ligament cells and establish their interplay with T cells via the Wnt10b pathway as a modulating factor for the anabolic properties of the hormone in periodontal regeneration PMID: 28071181
    7. findings provide the identification of autosomal-dominant WNT10B mutations in individuals with oligodontia, which increases the spectrum of congenital tooth agenesis and suggests attenuated Wnt signaling in endothelial differentiation of dental pulp stem cells. PMID: 27321946
    8. these findings clearly demonstrate that Wnt10b promotes epidermal keratinocyte transformation through induced Egf pathway PMID: 25995040
    9. Data show that Wnt protein Wnt10b is expressed in cardiomyocytes and localized in the intercalated discs of mouse and human hearts. PMID: 26338900
    10. WNT10B enhances proliferation through beta-catenin and RAC1 GTPase in human corneal endothelial cells. PMID: 26370090
    11. Sequence analysis of WNT10B gene revealed a novel 4-bp deletion mutation. PMID: 24211389
    12. No association between WNT10B polymorphisms and adiposity parameters was found. However, a role for WNT10B variants in determining human bone mineral density was found. PMID: 23325361
    13. Variations in WNT10B do not contribute to human monogenic obesity in our population. PMID: 23104151
    14. Hypoxia-inducible factor-2alpha-dependent hypoxic induction of Wnt10b expression in adipogenic cells. PMID: 23900840
    15. we identified WNT10B as a direct target of miR-148a in cancer-associated fibroblasts from endometrial cancers PMID: 22890324
    16. WNT10B/beta-catenin signalling induces HMGA2 and proliferation in metastatic breast cancer tumours devoid of ERalpha, PR and HER2 expression. PMID: 23307470
    17. Results suggest that Wnt10b likely plays an important role in the development of endometrial cancer (EC). The results also identify a role for Wnt10b in EC cells through promoting proliferation and inhibiting apoptosis. PMID: 23135473
    18. A novel sequence variant (c.986C>G, p.Thr329Arg) of WNT10B has been identified in familial split-hand/foot malformations in a large consanguineous Pakistani family. PMID: 21554266
    19. common variation in WNT10B was shown to be associated with BMI and weight in a case-control population of Belgian males. PMID: 22189080
    20. Wnt10b, but not Wnt3a, stimulates the NFkappaB and Notch pathways in U2OS osteosarcoma cells. PMID: 21321991
    21. This study is the first report of the association of common genetic polymorphism of WNT10B with human fat accumulation. PMID: 20579865
    22. Homozygous nonsense mutation in WNT10B is associated with sporadic split-hand/foot malformation with autosomal recessive inheritance. PMID: 20635353
    23. pyrethroid insecticides and estrogen can enhance the expression of the WNT10B proto-oncogene PMID: 12437293
    24. mutations represent the first naturally occurring missense variants of WNT10B PMID: 16477437
    25. suggest that fibroblast growth factor switches WNT10B from a negative to a positive cell growth regulator PMID: 17761539
    26. Metastatic osteosarcoma cell lines showed better chemotaxis response to Wnt10B than the non-metastatic osteosarcoma cell lines PMID: 18465804
    27. By homozygosity mapping a novel Split-Hand/Foot Malformation locus at 12q13.11-q13 with a maximum multipoint lod score of 5.47; by subsequent candidate gene approach a homozygous missense WNT10b mutation was identified. PMID: 18515319
    28. This analysis implicates the WNT10B locus as a genetic element in the regulation of bone mass and structural geometry. PMID: 19016593
    29. In Wnt10b-expressing mammary tumors, levels of p27(KIP1) were extremely low; conversely, Wnt10b-null mammary cells expressed high levels of this protein, suggesting Wnt-dependent regulation of p27(KIP1). PMID: 19056892
    30. S1P induces osteoblast precursor recruitment and promotes mature cell survival. Wnt10b and BMP6 also were significantly increased in mature osteoclasts, whereas sclerostin levels decreased during differentiation. PMID: 19075223
    31. We have not found evidence for a robust association of common WNT10B gene allelic variants with either BMD or fractures in postmenopausal women. PMID: 19458884

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  • 相關疾病：
    Split-hand/foot malformation 6 (SHFM6); Tooth agenesis, selective, 8 (STHAG8)
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix. Secreted.
  • 蛋白家族：
    Wnt family
  • 組織特異性：
    Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.
  • 數據庫鏈接：

    HGNC: 12775

    OMIM: 225300

    KEGG: hsa:7480

    STRING: 9606.ENSP00000301061

    UniGene: Hs.91985



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