在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Protein RIC-3 (RIC3), partial

Recombinant Human Protein RIC-3 (RIC3), partial

  • 中文名稱：
    人RIC3重組蛋白
  • 貨號：
    CSB-YP800217HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RIC3重組蛋白
  • 貨號：
    CSB-EP800217HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RIC3重組蛋白
  • 貨號：
    CSB-EP800217HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RIC3重組蛋白
  • 貨號：
    CSB-BP800217HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RIC3重組蛋白
  • 貨號：
    CSB-MP800217HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RIC3
  • Uniprot No.：
  • 別名：
    AYST720; FLJ11608; PRO1385; Protein RIC-3; Resistance to inhibitors of cholinesterase 3 homolog; Resistant to inhibitor of cholinesterase 3; RIC3 acetylcholine receptor chaperone; Ric3; RIC3_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.
  • 基因功能參考文獻：
    1. Two RIC3 gene haplotypes of four variants: A-G-C-G, and C-A-C-A might relate to either protection against or increased susceptibility to PD in the Han Chinese population, respectively. PMID: 28606768
    2. RIC3 mutations are not a common cause of PD in the French-Canadian and French populations. PMID: 28153381
    3. RIC3 is a known chaperone of neuronal nicotinic acetylcholine receptor subunit alpha-7 (CHRNA7). PMID: 27055476
    4. 5-HT3A-ICD is not only required but also sufficient for interaction with RIC-3 PMID: 27045630
    5. expression of chaperones such as Ric-3 can influence proteins associating with alpha7-nAChRs PMID: 26258666
    6. RIC-3 differentially regulates assembly and expression of different nicotinic receptor subunits. These results also show that nicotine-mediated upregulation of alpha4beta2 receptors can be dynamically regulated by the presence of the chaperone, RIC-3. PMID: 23586521
    7. RIC-3 gene rs1528133 variation was not found to be effective over any analyzed obesity related parameter, but associated with higher glycemic load, protein and fat eating behavior and antihypertensive drug use PMID: 23153976
    8. Xenopus laevis RIC-3 is more effective than either the homomeric human or C. elegans protein in chaperoning the expression of nematode nicotinic receptor ACR-16 in Xenopus oocytes. PMID: 22970690
    9. RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits. PMID: 20522555
    10. the hric3 locus encodes for multiple transcripts, is likely to produce multiple hric3 isoforms, and hric3 is expressed in neurons and muscles, thus enabling its interactions with nicotinic acetylcholine receptors in vivo PMID: 12821669
    11. ric-3 appears to be necessary for proper folding and/or assembly of alpha7 receptors in HEK293 cells PMID: 15504725
    12. RIC-3 may play a role in 5-HT(3A) receptor folding, assembly, or transport to the cell surface PMID: 15809299
    13. hRIC-3 can act as a specific regulator of alpha7 and 5-HT3 expression at different levels by increasing the number of mature receptors and facilitating its transport to the membrane PMID: 15927954
    14. Mutations in the ric-3 gene affect maturation of nicotinic acetylcholine receptors. PMID: 17192664
    15. both isoforms of RIC-3 play a role in determining 5-HT3 receptor composition. PMID: 17609200
    16. Immunohistochemistry demonstrated the presence of RIC-3 in rat brain localized, in general, in places where alpha7 nAChRs were found. PMID: 18179477
    17. When expressed in a human cell line, human RIC-3 enhances neuronal nicotinic acetylcholine receptor maturation more efficiently than Drosophila melanogaster RIC-3. PMID: 18208544
    18. this review provides a brief history of RIC-3--REVIEW PMID: 18246096
    19. we describe the generation and functional and pharmacological characterization of a Chinese hamster ovary (CHO)-K1 cell line co-expressing the human alpha7 nAChR and RIC-3 PMID: 18471073
    20. The RIC-3e protein is functionally active and enables surface expression of mature alpha7-nAChRs in cell lines not otherwise permissive for the expression of this receptor. PMID: 18691158

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
  • 蛋白家族：
    Ric-3 family
  • 組織特異性：
    Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophreni
  • 數據庫鏈接：

    HGNC: 30338

    OMIM: 610509

    KEGG: hsa:79608

    STRING: 9606.ENSP00000308820

    UniGene: Hs.231850



主站蜘蛛池模板： 久久不见久久见免费视频1′| 初尝黑人嗷嗷叫中文字幕| 日本在线视频www色| 亚洲国产精品第一区二区| 美女又黄又免费的视频| 亚洲一区二区三区无码久久| 欧美黑人xxxx又粗又长| 麻豆自媒体 一区 二区| 制服丝袜亚洲中文欧美在线| 精品人妻二区中文字幕| 成人国产一区二区三区| 香蕉免费一区二区三区在| 国产精品午夜福利不卡120| 国产精品自在线拍亚洲另类| 熟妇高潮一区二区三区| 动漫av纯肉无码av在线播放| 亚洲男人的天堂网站| 一区二区三区鲁丝不卡麻豆 | 曰韩a∨无码一区二区三区| 免费国产黄线在线观看| 欧美成人猛片aaaaaaa| 性色av极品无码专区亚洲| 亚洲另类成人小说综合网| 青青草国产三级精品三级 | 国产三级韩国三级日产三级 | 内射少妇36p亚洲区| 国产 高清 无码 在线播放| 亚洲人成电影免费观看在线看| 日本无码人妻一区二区色欲| 国产精品理论片| 成人午夜看黄在线尤物成人| 五月综合缴情婷婷六月| 日韩免费无码专区精品观看 | 国产精品久久久久久久久久久不卡| 久久香港三级台湾三级播放| 久久综合色_综合色88| 亚洲乱色熟女一区二区三区丝袜| 日本免费大黄在线观看| 女人张开腿让男人桶爽| 337p日本大胆欧久久| 少妇人妻大乳在线视频|