在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RIC3 Antibody

  • 中文名稱:
    RIC3兔多克隆抗體
  • 貨號:
    CSB-PA019707GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    RIC3
  • 別名:
    AYST720 antibody; FLJ11608 antibody; PRO1385 antibody; Protein RIC-3 antibody; Resistance to inhibitors of cholinesterase 3 homolog antibody; Resistant to inhibitor of cholinesterase 3 antibody; RIC3 acetylcholine receptor chaperone antibody; Ric3 antibody; RIC3_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human RIC3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.
  • 基因功能參考文獻:
    1. Two RIC3 gene haplotypes of four variants: A-G-C-G, and C-A-C-A might relate to either protection against or increased susceptibility to PD in the Han Chinese population, respectively. PMID: 28606768
    2. RIC3 mutations are not a common cause of PD in the French-Canadian and French populations. PMID: 28153381
    3. RIC3 is a known chaperone of neuronal nicotinic acetylcholine receptor subunit alpha-7 (CHRNA7). PMID: 27055476
    4. 5-HT3A-ICD is not only required but also sufficient for interaction with RIC-3 PMID: 27045630
    5. expression of chaperones such as Ric-3 can influence proteins associating with alpha7-nAChRs PMID: 26258666
    6. RIC-3 differentially regulates assembly and expression of different nicotinic receptor subunits. These results also show that nicotine-mediated upregulation of alpha4beta2 receptors can be dynamically regulated by the presence of the chaperone, RIC-3. PMID: 23586521
    7. RIC-3 gene rs1528133 variation was not found to be effective over any analyzed obesity related parameter, but associated with higher glycemic load, protein and fat eating behavior and antihypertensive drug use PMID: 23153976
    8. Xenopus laevis RIC-3 is more effective than either the homomeric human or C. elegans protein in chaperoning the expression of nematode nicotinic receptor ACR-16 in Xenopus oocytes. PMID: 22970690
    9. RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits. PMID: 20522555
    10. the hric3 locus encodes for multiple transcripts, is likely to produce multiple hric3 isoforms, and hric3 is expressed in neurons and muscles, thus enabling its interactions with nicotinic acetylcholine receptors in vivo PMID: 12821669
    11. ric-3 appears to be necessary for proper folding and/or assembly of alpha7 receptors in HEK293 cells PMID: 15504725
    12. RIC-3 may play a role in 5-HT(3A) receptor folding, assembly, or transport to the cell surface PMID: 15809299
    13. hRIC-3 can act as a specific regulator of alpha7 and 5-HT3 expression at different levels by increasing the number of mature receptors and facilitating its transport to the membrane PMID: 15927954
    14. Mutations in the ric-3 gene affect maturation of nicotinic acetylcholine receptors. PMID: 17192664
    15. both isoforms of RIC-3 play a role in determining 5-HT3 receptor composition. PMID: 17609200
    16. Immunohistochemistry demonstrated the presence of RIC-3 in rat brain localized, in general, in places where alpha7 nAChRs were found. PMID: 18179477
    17. When expressed in a human cell line, human RIC-3 enhances neuronal nicotinic acetylcholine receptor maturation more efficiently than Drosophila melanogaster RIC-3. PMID: 18208544
    18. this review provides a brief history of RIC-3--REVIEW PMID: 18246096
    19. we describe the generation and functional and pharmacological characterization of a Chinese hamster ovary (CHO)-K1 cell line co-expressing the human alpha7 nAChR and RIC-3 PMID: 18471073
    20. The RIC-3e protein is functionally active and enables surface expression of mature alpha7-nAChRs in cell lines not otherwise permissive for the expression of this receptor. PMID: 18691158

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
  • 蛋白家族:
    Ric-3 family
  • 組織特異性:
    Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophreni
  • 數(shù)據(jù)庫鏈接:

    HGNC: 30338

    OMIM: 610509

    KEGG: hsa:79608

    STRING: 9606.ENSP00000308820

    UniGene: Hs.231850



主站蜘蛛池模板: 被窝影院午夜无码国产| 天堂网www中文在线| 日韩精品一区二区av在线观看 | 女人夜夜春高潮爽a∨片| 亚洲精品成人网站在线观看| 亚洲欧美精品aaaaaa片| 四虎永久在线精品免费视频观看| 成人影院永久免费观看网址| 131美女爱做视频免费| 国产成人久久av免费高潮| 婷婷色香合缴缴情av第三区 | 国产成人免费无码av在线播放| 亚洲男人的天堂在线va| 草的我好爽视频| 久久久久久欧美精品se一二三四 | 亚洲国产午夜精品理论片在线播放 | 国产精品久久久久久亚洲| 亚洲熟妇无码久久精品| 国产女人天天春夜夜春| 久久99日韩国产精品久久99| 久久99精品九九九久久婷婷| 男女性杂交内射女bbwxz| 六月丁香综合在线视频| 9lporm自拍视频区| 久久亚洲精品成人av| 亚洲精品自产拍在线观看| 久久久女人与动物群交毛片| 久久精品久久久久观看99水蜜桃| 女人张开腿让男桶喷水高潮| 日韩av片无码一区二区三区| 久久理论片午夜琪琪电影院 | 国产精品久久久午夜夜伦鲁鲁| 亚洲欧洲专线一区| 又爽又黄又无遮挡网站| 亚洲国产精品一区二区成人片国内| 欧美性生 活18~19| 一本大道久久东京热av| 久久精品aⅴ无码中文字字幕| 免费ā片在线观看| 男女野外做爰全过程69影院| 色综合天天综合欧美综合|