在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human NUT family member 1 (NUTM1), partial

Recombinant Human NUT family member 1 (NUTM1), partial

  • 中文名稱：
    人NUTM1重組蛋白
  • 貨號：
    CSB-YP773056HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NUTM1重組蛋白
  • 貨號：
    CSB-EP773056HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NUTM1重組蛋白
  • 貨號：
    CSB-EP773056HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NUTM1重組蛋白
  • 貨號：
    CSB-BP773056HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NUTM1重組蛋白
  • 貨號：
    CSB-MP773056HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NUTM1
  • Uniprot No.：
  • 別名：
    C15orf55; Chromosome 15 open reading frame 55; DKFZp434O192; MGC138683; MGC138684; Nuclear protein in testis; NUT; NUT_HUMAN; Protein NUT
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

相關產品

靶點詳情

  • 功能：
    Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites.
  • 基因功能參考文獻：
    1. Fluorescence in situ hybridization and targeted next-generation sequencing identified a CIC-NUTM1 fusion resulting from t(15;19)(q14;q13.2). In light of morphologic features that overlap with those of NC from typical anatomical sites we have seen previously, the tumor was best classified as falling within the NC spectrum rather than CIC-associated sarcoma. PMID: 29700887
    2. Review and case series found that NUT midline carcinoma has dismal prognosis. Radiotherapy and chemotherapy improves survival, but do not provide long term control except in anecdotal cases. No impact on overall survival was found based on type of molecular translocation, i.e., NUT-BRD4, NUT-BRD3 or other variants. PMID: 29356890
    3. We postulate that BRD4-NUT (B4N) complexes override the preexisting histone code with new posttranslational modifications patterns that reflect aberrant transcription and that epigenetically modulate the nucleosome environment toward the NUT-midline carcinoma (NMC) state. PMID: 27698495
    4. we also identified a complex genomic rearrangement involving the BRD4-NUT rearrangement underlying the simple t(15;19) karyotype in Nuclear protein in testis (NUT) midline carcinoma PMID: 28203693
    5. The clinical, radiographic, and histopathologic features of NUT midline carcinoma are discussed, as well as its management options. PMID: 24892275
    6. NUT gene rearrangement does not seem to be relevant in primary pulmonary carcinomas or carcinoid tumours of the lung PMID: 26341600
    7. Authors identified eight cases of primary pulmonary NMC over 4 years and, using a NUT immunohistochemistry screen, retrospectively identified one additional case from 166 consecutive biopsies of lung carcinomas lacking glandular differentiation. PMID: 26001144
    8. discovered that the translocation oncoprotein BRD4-NUT protein occupies approximately 100-200 extremely broad, cell type-specific hyperacetylated domains in the genome PMID: 26220994
    9. Thirty-seven (76%) malignant germ cell tumors were NUT positive but staining was usually of weak to moderate intensity and observed in a relatively small proportion of neoplastic cells. PMID: 25551299
    10. Data support a model in which BRD4-NUT-stimulated histone hyperacetylation recruits additional BRD4 and interacting partners to support transcriptional activation, which underlies the BRD4-NUT oncogenic mechanism in NMC. PMID: 25512383
    11. The involvement of the NSD3 methyltransferase as a component of the NUT fusion protein oncogenic complex identifies a new potential therapeutic target. PMID: 24875858
    12. Case Report: NUT midline carcinoma in the nasal cavity with BRD4-NUT-rearrangement. PMID: 24655834
    13. Four cases with the expression of P16 in NUT carcinomas with no association with human papillomavirus are being described. PMID: 24185123
    14. Determination of NUT protein expression and gene rearrangement can allow the differentiation of NUT midline carcinoma from upper-respiratory tract poorly differentiated malignant tumors PMID: 22777717
    15. immunohistochemical study of 21 cases revealed a lack of nuclear expression of NUT by undifferentiated (anaplastic) thyroid carcinomas PMID: 23701453
    16. The novel BRD4-NUT fusion in which Exon 15 of BRD4 was fused to Exon 2 of NUT encodes a functional protein that is central to the oncogenic mechanism in these cells. PMID: 23128391
    17. Only one thymic carcinoma (2.7% of thymic carcinomas or 0.68% of TETs) was found positive for NUT expression and rearrangement PMID: 22425924
    18. Case Reports: 2 pediatric cases of nuclear protein of the testis (NUT) midline carcinoma suggestive of pulmonary origin. PMID: 22301500
    19. study provides a novel mechanism by which the BRD4-NUT oncogene perturbs BRD4 functions to block cellular differentiation and to contribute to the oncogenic progression in the highly aggressive NUT midline carcinoma PMID: 21652721
    20. NUT gene rearrangement is associated with squamous cell carcinoma of the lung with long time survival. PMID: 20871268
    21. Using a patient-derived cell line, the authors show that p300 sequestration into the chromatin-bound BRD4-NUT fusion protein foci is the principal oncogenic mechanism leading to p53 inactivation. PMID: 20676058
    22. Wild type Brd4 inhibits G(1) to S progression and we also found that the Brd4-NUT fusion augments the inhibition of progression to S phase compared with wild type Brd4. PMID: 15994877
    23. BRD-NUT fusion proteins contribute to carcinogenesis by associating with chromatin and interfering with epithelial differentiation. PMID: 17934517
    24. Approximately, 20% of undifferentiated carcinomas of the upper aerodigestive tract not associated with EBV infection were found to have rearrangements of NUT by FISH. PMID: 18391746
    25. Some carcinomas of the upper aerodigestive tract have a rearrangement of the nuclear protein of the testis (NUT) gene (NUT midline carcinomas). PMID: 19550370

    顯示更多

    收起更多

  • 相關疾病：
    A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUT fusion protein.
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    NUT family
  • 組織特異性：
    Specifically expressed in testis.
  • 數據庫鏈接：

    HGNC: 29919

    OMIM: 608963

    KEGG: hsa:256646

    STRING: 9606.ENSP00000329448

    UniGene: Hs.525769



主站蜘蛛池模板： 亚洲日韩乱码中文字幕| 亚洲大片av毛片免费| 亚洲中字幕日产av片在线| 国产av天堂亚洲国产av麻豆| 无码人妻一区二区三区四区av| 精品久久久久久久国产潘金莲 | 亚洲精品天堂成人片av在线播放 | 无码av岛国片在线播放| 亚洲制服丝中文字幕| 色偷偷亚洲第一成人综合网址| 久久人妻夜夜做天天爽| 亚洲 a v无 码免 费 成 人 a v| 性欧美熟妇videofreesex| 少妇性俱乐部纵欲狂欢电影| 少妇又紧又深又湿又爽视频| 水蜜桃精品一二三| 欧美成人精品三级网站视频| 国产精品va在线播放| 国产精品久久久午夜夜伦鲁鲁| 欧美大成色www永久网站婷| 国产无遮挡又爽又刺激的视频老师| 真人性生交免费视频| 色综合视频一区中文字幕 | 99精品一区二区三区无码吞精| 亚洲 激情 小说 另类 欧美 | 亚洲精品一区二区| 国产精品久久自在自线青柠| 3d动漫精品啪啪一区二区中 | 无码h肉动漫在线观看免费| 精产国品一二三产品麻豆| 亚洲伊人久久大香线蕉av| 国产精品久久国产精品99| 国产精品亚洲片夜色在线| 久久亚洲国产精品影院| 无码纯肉动漫在线观看| 国产成人无码av一区二区| 精品熟女少妇av免费观看| 国产极品美女到高潮| 日韩综合亚洲色在线影院| 日本三级欧美三级人妇视频| 三上悠亚ssⅰn939无码播放 |