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  4. Recombinant Human Protein MMS22-like (MMS22L), partial

Recombinant Human Protein MMS22-like (MMS22L), partial

  • 中文名稱：
    人MMS22L重組蛋白
  • 貨號：
    CSB-YP751174HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MMS22L重組蛋白
  • 貨號：
    CSB-EP751174HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MMS22L重組蛋白
  • 貨號：
    CSB-EP751174HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MMS22L重組蛋白
  • 貨號：
    CSB-BP751174HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MMS22L重組蛋白
  • 貨號：
    CSB-MP751174HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MMS22L
  • Uniprot No.：
  • 別名：
    C6orf167; C6orf167 chromosome 6 open reading frame 167; chromosome 6 open reading frame 167; dJ39B17.2; DKFZp686C20164; DKFZp781C2113; FLJ46180; homologous to yeast Mms22; KIAA1900; Methyl methanesulfonate-sensitivity protein 22-like; MMS22 like, DNA repair protein; Mms22-like protein; MMS22_HUMAN; MMS22L; OTTHUMP00000221009; Protein MMS22-like; Uncharacterized protein C6orf167
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA.
  • 基因功能參考文獻：
    1. By specifically regulating RAD51 activity at uncoupled replication forks, MMS22L-TONSL stabilizes perturbed replication forks by promoting replication fork reversal and stimulating their homologous recombination-mediated restart in vivo. PMID: 27797818
    2. new histones incorporated during DNA replication provide a signature of post-replicative chromatin, read by the human TONSL-MMS22L homologous recombination complex PMID: 27338793
    3. Our data strongly suggest that targeting MMS22L as well as its interaction with NFKBIL2 could be a promising strategy for novel cancer treatments. PMID: 22895565
    4. Results strongly suggest that the Mms22L-Nfkbil2 complex contributes to genome stability by regulating the chromatin state at stalled replication forks. PMID: 21113133
    5. These results indicate that MMS22L and TONSL are genome caretakers that stimulate the recombination-dependent repair of stalled or collapsed replication forks. PMID: 21055983
    6. MMS22L and TONSL are required for the maintenance of genome stability. PMID: 21055984
    7. This study identifies MMS22L-NFKBIL2 as components of the replication stress control pathway. PMID: 21055985

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  • 亞細胞定位：
    Nucleus. Note=Localizes to DNA damage sites, accumulates at stressed replication forks.
  • 蛋白家族：
    MMS22 family, MMS22L subfamily
  • 數據庫鏈接：

    HGNC: 21475

    OMIM: 615614

    KEGG: hsa:253714

    STRING: 9606.ENSP00000275053

    UniGene: Hs.444292



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