在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein FAM134B (FAM134B), partial

  • 中文名稱:
    人RETREG1重組蛋白
  • 貨號:
    CSB-YP875683HU1
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人RETREG1重組蛋白
  • 貨號:
    CSB-EP875683HU1
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人RETREG1重組蛋白
  • 貨號:
    CSB-EP875683HU1-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人RETREG1重組蛋白
  • 貨號:
    CSB-BP875683HU1
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人RETREG1重組蛋白
  • 貨號:
    CSB-MP875683HU1
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    RETREG1
  • Uniprot No.:
  • 別名:
    RETREG1; FAM134B; JK1; Reticulophagy regulator 1; Reticulophagy receptor 1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons.
  • 基因功能參考文獻:
    1. the expression level of JK-1 is correlated with the clinicopathological features of esophageal carcinoma PMID: 29937447
    2. FAM134B promoter methylation plays a key role in regulating FAM134B expression in vitro and in vivo, which in turn contributes to the prediction of the biological aggressiveness of colorectal adenocarcinomas. PMID: 29318692
    3. These findings imply that mutation might be the major driving source of FAM134B genetic modulation in oesophageal squamous cell carcinoma. PMID: 27373372
    4. NS3-mediated cleavage of FAM134B blocks the formation of endoplasmic reticulum and viral protein-enriched autophagosomes. PMID: 28102736
    5. miR-186-5p expression promotes colorectal cancer pathogenesis by regulating tumour suppressor FAM134B PMID: 28549913
    6. FAM134B protein was noted in both cytoplasm and nuclei of colon cancer cells. In cancer cells derived from stage IV colon cancer, FAM134B expression was remarkably reduced when compared to non-cancer colon cells and cancer cells derived from stage II colon cancer. FAM134B knockdown significantly (P < 0.05) increased the proliferation of colon cancer cells following lentiviral transfection. PMID: 27120410
    7. FAM134B mutation is common in colorectal cancer. The association of the mutation of this gene with adverse clinical and pathological parameters is congruent with the tumour suppressive properties of the gene PMID: 28144752
    8. selective endoplasmic reticulum (ER)-phagy via FAM134 proteins is indispensable for mammalian cell homeostasis and controls ER morphology and turnover in mice and humans PMID: 26040720
    9. The changes in JK1 DNA copy number associated with progression of colorectal neoplasms.A decrease in JK-1 copy number was correlated with a shorter disease-free survival time. PMID: 24825067
    10. FAM134B represses cell migration in colon cancer.FAM134B has functional role in the pathogenesis of colon cancer. PMID: 24927874
    11. Low FAM134B expression is associated with colorectal cancer. PMID: 24973512
    12. Results show the interplay between promoter SNPs of CD39 and FAM134B results in an intercellular epistasis which influences the risk of a complex inflammatory disease. PMID: 24970562
    13. Homozygous FAM134B mutation was found in Turkish siblings with hereditary sensory neuropathy type 2. PMID: 24327336
    14. case report of homozygous nonsense mutation p.Q145X causing severe hereditary sensory neuropathy PMID: 21115472
    15. The FAM134B and TNFRSF19 showed a dramatically strong synergistic epistasis in explaining the genetic dissection of the susceptibility to complex vascular dementia. PMID: 21127458
    16. The overexpression of JK-1(FAM134b) and its transforming capacity in normal cells may play a critical role in the molecular pathogenesis of esophageal squamous cell carcinoma. PMID: 17487424
    17. show that loss-of-function mutations in FAM134B, encoding a newly identified cis-Golgi protein, cause hereditary sensory and autonomic neuropathy type II. PMID: 19838196

    顯示更多

    收起更多

  • 相關疾病:
    Neuropathy, hereditary sensory and autonomic, 2B (HSAN2B)
  • 亞細胞定位:
    Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    RETREG family
  • 組織特異性:
    Overexpressed in esophageal squamous cell carcinoma.
  • 數據庫鏈接:

    HGNC: 25964

    OMIM: 613114

    KEGG: hsa:54463

    STRING: 9606.ENSP00000304642

    UniGene: Hs.481704



主站蜘蛛池模板: 欧洲美洲精品一区二区三区| 日本一上一下爱爱免费| 少妇被又大又粗又爽毛片| 亚洲性无码av在线dvd| 美国人性欧美xxxx| 国产精品一区二区无线| 老熟女五十路乱子交尾中出一区| 自愉自愉产区二十四区| 18处破外女出血在线| 伊人伊成久久人综合网996 | 欧美 亚洲 日韩 中文2019| 亚洲精品久久久久午夜福禁果tⅴ| 又粗又大内射免费视频小说| 国产亚洲精品久久久久久| 呦男呦女视频精品八区| 亚洲成国产人片在线观看| 精品国产午夜福利精品推荐| 国产亚洲美女精品久久久2020| 特黄大片又粗又大又暴| 无码少妇精品一区二区免费动态| 国产美女精品自在线拍免费| 久久精品av一区二区免费| 中文毛片无遮挡高潮免费| 麻豆人妻少妇精品无码专区| 国产有奶水哺乳期无码avav| 中国少妇内射xxxhd| 蜜臀avwww国产天堂| 国产熟妇久久777777| 日本精品久久久久中文字幕| 国产亚洲精品美女在线| 丰满少妇高潮惨叫久久久| 亚洲免费观看在线视频| 欧美一区二区三区视频在线观看 | 青青草国产三级精品三级| 午夜无码成人免费视频| 国产大屁股喷水视频在线观看| 精品蜜臀av在线天堂| 大狠狠大臿蕉香蕉大视频| 无码视频一区二区三区| 国产精品人人爽人人做我的可爱| 国产精品亚洲精品日韩己满十八小 |