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  4. FAM134B Antibody, Biotin conjugated

FAM134B Antibody, Biotin conjugated

  • 中文名稱：
    FAM134B兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA875683LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RETREG1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RETREG1
  • 別名：
    RETREG1; FAM134B; JK1; Reticulophagy regulator 1; Reticulophagy receptor 1
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Reticulophagy receptor FAM134B protein (1-131AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons.
  • 基因功能參考文獻(xiàn)：
    1. the expression level of JK-1 is correlated with the clinicopathological features of esophageal carcinoma PMID: 29937447
    2. FAM134B promoter methylation plays a key role in regulating FAM134B expression in vitro and in vivo, which in turn contributes to the prediction of the biological aggressiveness of colorectal adenocarcinomas. PMID: 29318692
    3. These findings imply that mutation might be the major driving source of FAM134B genetic modulation in oesophageal squamous cell carcinoma. PMID: 27373372
    4. NS3-mediated cleavage of FAM134B blocks the formation of endoplasmic reticulum and viral protein-enriched autophagosomes. PMID: 28102736
    5. miR-186-5p expression promotes colorectal cancer pathogenesis by regulating tumour suppressor FAM134B PMID: 28549913
    6. FAM134B protein was noted in both cytoplasm and nuclei of colon cancer cells. In cancer cells derived from stage IV colon cancer, FAM134B expression was remarkably reduced when compared to non-cancer colon cells and cancer cells derived from stage II colon cancer. FAM134B knockdown significantly (P < 0.05) increased the proliferation of colon cancer cells following lentiviral transfection. PMID: 27120410
    7. FAM134B mutation is common in colorectal cancer. The association of the mutation of this gene with adverse clinical and pathological parameters is congruent with the tumour suppressive properties of the gene PMID: 28144752
    8. selective endoplasmic reticulum (ER)-phagy via FAM134 proteins is indispensable for mammalian cell homeostasis and controls ER morphology and turnover in mice and humans PMID: 26040720
    9. The changes in JK1 DNA copy number associated with progression of colorectal neoplasms.A decrease in JK-1 copy number was correlated with a shorter disease-free survival time. PMID: 24825067
    10. FAM134B represses cell migration in colon cancer.FAM134B has functional role in the pathogenesis of colon cancer. PMID: 24927874
    11. Low FAM134B expression is associated with colorectal cancer. PMID: 24973512
    12. Results show the interplay between promoter SNPs of CD39 and FAM134B results in an intercellular epistasis which influences the risk of a complex inflammatory disease. PMID: 24970562
    13. Homozygous FAM134B mutation was found in Turkish siblings with hereditary sensory neuropathy type 2. PMID: 24327336
    14. case report of homozygous nonsense mutation p.Q145X causing severe hereditary sensory neuropathy PMID: 21115472
    15. The FAM134B and TNFRSF19 showed a dramatically strong synergistic epistasis in explaining the genetic dissection of the susceptibility to complex vascular dementia. PMID: 21127458
    16. The overexpression of JK-1(FAM134b) and its transforming capacity in normal cells may play a critical role in the molecular pathogenesis of esophageal squamous cell carcinoma. PMID: 17487424
    17. show that loss-of-function mutations in FAM134B, encoding a newly identified cis-Golgi protein, cause hereditary sensory and autonomic neuropathy type II. PMID: 19838196

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  • 相關(guān)疾病：
    Neuropathy, hereditary sensory and autonomic, 2B (HSAN2B)
  • 亞細(xì)胞定位：
    Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    RETREG family
  • 組織特異性：
    Overexpressed in esophageal squamous cell carcinoma.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25964

    OMIM: 613114

    KEGG: hsa:54463

    STRING: 9606.ENSP00000304642

    UniGene: Hs.481704



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