在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein AF1q (MLLT11)

  • 中文名稱:
    人MLLT11重組蛋白
  • 貨號:
    CSB-YP618752HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人MLLT11重組蛋白
  • 貨號:
    CSB-EP618752HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人MLLT11重組蛋白
  • 貨號:
    CSB-EP618752HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人MLLT11重組蛋白
  • 貨號:
    CSB-BP618752HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人MLLT11重組蛋白
  • 貨號:
    CSB-MP618752HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    MLLT11
  • Uniprot No.:
  • 別名:
    AF1Q; AF1Q_HUMAN; ALL1 fused gene from chromosome 1q; MLLT 11; MLLT11; Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog; Drosophila) translocated to 11; Protein AF1q; RP11 316M1.10
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-90
  • 氨基酸序列
    MRDPVSSQYS SFLFWRMPIP ELDLSELEGL GLSDTATYKV KDSSVGKMIG QATAADQEKN PEGDGLLEYS TFNFWRAPIA SIHSFELDLL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate.
  • 基因功能參考文獻:
    1. AF1q was up-regulated in human colorectal cancer tissues, and that this up-regulation was associated with tumor metastasis. AF1q contributes to CRC tumorigenesis through the activation of the AKT signaling pathway. PMID: 28475127
    2. Data show that MLLT11/AF1q-induced PDGFR signaling enhanced STAT3 activity through Src kinase activation. PMID: 27259262
    3. AF1q was significantly lower in borderline ovarian tumors (i.e., tumors of low malignant potential without stromal invasion) than in invasive tumors, thus corroborating the association between high AF1q expression and increased migratory/invasive cell behavior and confirming its potential role in ovarian cancer progression. PMID: 28423573
    4. These results suggest that AF1q would have a role as an enhancer in generation of stem-like population through activation of Wnt signaling pathway. PMID: 28188793
    5. Findings indicate that breast cancer cells with a hyperactive AF1q/TCF7/CD44 regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties. PMID: 26079538
    6. Results demonstrate that AF1q gene transcription is regulated by REST through direct binding at -383 to -363 bp of AF1q promoter. PMID: 26341630
    7. AF1Q had a KFERQ-like motif. PMID: 24880125
    8. AF1q plays a role in the onset of basal apoptosis in ovarian cancer cells, thus providing new information about the activity of this protein whose biologic functions are mostly unknown PMID: 22761939
    9. Using in vitro assays based on either forced expression or shRNA-mediated silencing of AF1q, the study provides evidence that the protein promotes T- over B-cell differentiation in multipotent hematopoietic progenitors. PMID: 21715312
    10. AF1q up-regulation of BAD is through its effect on NF-kappaB and this may hint of its oncogenic mechanism in cancer. PMID: 20596645
    11. The ectopic expression of human AF1q triggered the expression of the neuronal marker TuJ1 in non-neuronal human embryonic kidney (HEK) cells. PMID: 15530661
    12. overexpression of AF1Q leads to more progression in human breast cancer PMID: 17929166
    13. The study provides the first evidence that AF1q plays a critical role in the regulation of apoptosis and drug resistance. PMID: 18852119
    14. high AF1q expression is a poor prognostic marker for adult patients with normal cytogenetics acute myeloid leukemia PMID: 19396856

    顯示更多

    收起更多

  • 相關疾?。?/div>
    A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.
  • 亞細胞定位:
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族:
    MLLT11 family
  • 組織特異性:
    Expressed in myoepithelial cells of normal breast tissue (at protein level). Highly expressed in thymus. Expressed in colon, small intestine, prostate and ovary. Not detected in peripheral blood lymphocytes and spleen.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 16997

    OMIM: 604684

    KEGG: hsa:10962

    STRING: 9606.ENSP00000357917

    UniGene: Hs.75823



主站蜘蛛池模板: 欧美裸体xxxx极品少妇 | 综合亚洲综合图区网友自拍| 欧美日韩无线码在线观看| 国产网红无码精品视频| 亚洲精品成人久久久| 色综合天天综合网中文| 久热这里只有精品99在线观看 | 又粗又大又硬毛片免费看| 久久久综合九色综合鬼色| 大又大粗又爽又黄少妇毛片免费 | 96国产xxxx免费视频| 午夜片无码区私人影院| 色偷拍 自怕 亚洲 10p| 在线无码免费的毛片视频| 午夜大片男女免费观看爽爽爽尤物| 放荡的少妇2欧美版| 亚洲精品一区二区三区不卡| 九九热线有精品视频| 久久精品国产久精国产爱| 少妇激情一区二区三区视频| 亚欧洲乱码视频一二三区| 开心五月综合亚洲| 五月色婷婷丁香无码三级| 少妇久久久久久被弄高潮| 色婷婷综合久久久久中文字幕| 国产成人午夜福利在线小电影| 久久人人做人人爽人人av| 欧美性受xxxx白人性爽| 国产成人亚洲精品无码h在线| 久久亚洲精品无码网站| 天堂在线最新版www中文| 天堂无码人妻精品av一区 | 亚洲最大成人av在线天堂网| 美女国产毛片a区内射| 亚洲欧美日韩中文播放| 亚洲精品无码乱码成人| 无码孕妇孕交在线观看| 亚洲精品~无码抽插| 久久久久久成人综合网| 亚洲中文字幕无码久久| 欧美日韩免费做爰大片人|