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  4. Recombinant Human Proprotein convertase subtilisin/kexin type 5 (PCSK5), partial

Recombinant Human Proprotein convertase subtilisin/kexin type 5 (PCSK5), partial

  • 中文名稱：
    人PCSK5重組蛋白
  • 貨號：
    CSB-YP017644HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PCSK5重組蛋白
  • 貨號：
    CSB-EP017644HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PCSK5重組蛋白
  • 貨號：
    CSB-EP017644HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PCSK5重組蛋白
  • 貨號：
    CSB-BP017644HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PCSK5重組蛋白
  • 貨號：
    CSB-MP017644HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PCSK5
  • Uniprot No.：
  • 別名：
    FLJ11149; FLJ16215; hPC6; PC5; PC6; PC6A; Pcsk5; PCSK5_HUMAN; Prohormone convertase 5; Proprotein convertase 5; Proprotein convertase 6; Proprotein convertase PC5; Proprotein convertase subtilisin/kexin type 5; Protease PC6; SPC6; Subtilisin/kexin-like protease PC5
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.
  • 基因功能參考文獻：
    1. loss of the convertase furin or PC5/6 in hepatocytes results in a approximately 30% decrease in APC levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin activation. PMID: 28468828
    2. Case Report: whole exome sequencing of a case with the VACTERL association uncovered a novel frameshift mutation in the PCSK5 gene. PMID: 26055999
    3. full-length alpha-DG in the human endometrial epithelium is a barrier for embryo attachment and that removal of alpha-DG-N by proprotein convertase 5/6 (PC6; a protease critical for implantation PMID: 26077903
    4. Proprotein convertase 5/6 cleaves PDGFA in the human endometrium in preparation for embryo implantation. PMID: 25429785
    5. PC5/6A is involved in squamous differentiation of human nasal epithelial cells, possibly through up-regulation of the BMP-2 signaling pathway. PMID: 25350918
    6. study implicates PC6 as a key regulatory protein essential for the attachment of the blastocyst to the endometrial epithelium through the processing of pro-integrin-alphas PMID: 22740495
    7. PC6 plays a key role in regulating fundamental cellular remodeling processes, such as plasma membrane transformation and membrane-cytoskeletal interface reorganization. PMID: 21971156
    8. Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A. PMID: 21700711
    9. PC6 may have a role in uterine receptivity and its uterine lavage levels appear to be significantly lower in a subgroup of women with unexplained infertility PMID: 21273245
    10. PTPkappa was scissored by the processed form of proprotein convertase 5, and galectin-3 binding protein which is over-produced in colon cancer cells and tissues. PMID: 21094132
    11. The proteolytic activation and thus bioavailability of BMP2 is controlled by PC6. PMID: 20555025
    12. Variability at the PCSK5 locus influences high-density lipoprotein cholesterol levels. PMID: 20031622
    13. Results describe the mechanisms of PC6 action in decidualization and identify caldesmon as one of its physiological substrates. PMID: 19764806
    14. PC5/6 plays a key role for decidualization in human endometrium. PMID: 15522936
    15. PC6 is an essential molecule in modulating uterine function to support the establishment of embryo implantation PMID: 15601911
    16. in binding VEGFR-2, furin and PC5 promote cleavage of N-and C-terminal VEGF-D propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only PMID: 17242158
    17. after stimulation, the protease activity of PC5A is enhanced, as evidenced by the cleavage of the PC5A substrates Lefty, ADAMTS-4, endothelial lipase, and PCSK9. PMID: 18039650
    18. We propose that Pcsk5, at least in part via GDF11, coordinately regulates caudal Hox paralogs, to control anteroposterior patterning, nephrogenesis, skeletal, and anorectal development. PMID: 18519639

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  • 亞細胞定位：
    [Isoform PC6A]: Secreted.; [Isoform PC6B]: Endomembrane system; Single-pass type I membrane protein.
  • 蛋白家族：
    Peptidase S8 family
  • 組織特異性：
    Expressed in T-lymphocytes.
  • 數據庫鏈接：

    HGNC: 8747

    OMIM: 600488

    KEGG: hsa:5125

    STRING: 9606.ENSP00000446280

    UniGene: Hs.368542



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