在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PCSK5 Antibody, HRP conjugated

  • 中文名稱:
    PCSK5兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA017644LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PCSK5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PCSK5
  • 別名:
    FLJ11149 antibody; FLJ16215 antibody; hPC6 antibody; PC5 antibody; PC6 antibody; PC6A antibody; Pcsk5 antibody; PCSK5_HUMAN antibody; Prohormone convertase 5 antibody; Proprotein convertase 5 antibody; Proprotein convertase 6 antibody; Proprotein convertase PC5 antibody; Proprotein convertase subtilisin/kexin type 5 antibody; Protease PC6 antibody; SPC6 antibody; Subtilisin/kexin-like protease PC5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Proprotein convertase subtilisin/kexin type 5 protein (201-500AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.
  • 基因功能參考文獻:
    1. loss of the convertase furin or PC5/6 in hepatocytes results in a approximately 30% decrease in APC levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin activation. PMID: 28468828
    2. Case Report: whole exome sequencing of a case with the VACTERL association uncovered a novel frameshift mutation in the PCSK5 gene. PMID: 26055999
    3. full-length alpha-DG in the human endometrial epithelium is a barrier for embryo attachment and that removal of alpha-DG-N by proprotein convertase 5/6 (PC6; a protease critical for implantation PMID: 26077903
    4. Proprotein convertase 5/6 cleaves PDGFA in the human endometrium in preparation for embryo implantation. PMID: 25429785
    5. PC5/6A is involved in squamous differentiation of human nasal epithelial cells, possibly through up-regulation of the BMP-2 signaling pathway. PMID: 25350918
    6. study implicates PC6 as a key regulatory protein essential for the attachment of the blastocyst to the endometrial epithelium through the processing of pro-integrin-alphas PMID: 22740495
    7. PC6 plays a key role in regulating fundamental cellular remodeling processes, such as plasma membrane transformation and membrane-cytoskeletal interface reorganization. PMID: 21971156
    8. Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A. PMID: 21700711
    9. PC6 may have a role in uterine receptivity and its uterine lavage levels appear to be significantly lower in a subgroup of women with unexplained infertility PMID: 21273245
    10. PTPkappa was scissored by the processed form of proprotein convertase 5, and galectin-3 binding protein which is over-produced in colon cancer cells and tissues. PMID: 21094132
    11. The proteolytic activation and thus bioavailability of BMP2 is controlled by PC6. PMID: 20555025
    12. Variability at the PCSK5 locus influences high-density lipoprotein cholesterol levels. PMID: 20031622
    13. Results describe the mechanisms of PC6 action in decidualization and identify caldesmon as one of its physiological substrates. PMID: 19764806
    14. PC5/6 plays a key role for decidualization in human endometrium. PMID: 15522936
    15. PC6 is an essential molecule in modulating uterine function to support the establishment of embryo implantation PMID: 15601911
    16. in binding VEGFR-2, furin and PC5 promote cleavage of N-and C-terminal VEGF-D propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only PMID: 17242158
    17. after stimulation, the protease activity of PC5A is enhanced, as evidenced by the cleavage of the PC5A substrates Lefty, ADAMTS-4, endothelial lipase, and PCSK9. PMID: 18039650
    18. We propose that Pcsk5, at least in part via GDF11, coordinately regulates caudal Hox paralogs, to control anteroposterior patterning, nephrogenesis, skeletal, and anorectal development. PMID: 18519639

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform PC6A]: Secreted.; [Isoform PC6B]: Endomembrane system; Single-pass type I membrane protein.
  • 蛋白家族:
    Peptidase S8 family
  • 組織特異性:
    Expressed in T-lymphocytes.
  • 數據庫鏈接:

    HGNC: 8747

    OMIM: 600488

    KEGG: hsa:5125

    STRING: 9606.ENSP00000446280

    UniGene: Hs.368542



主站蜘蛛池模板: 久久久久国产精品无码免费看| 亚洲精品无码成人av电影网| 18女下面流水不遮图| 青青草国产精品久久久久| 中文字幕中文乱码www| 真实国产老熟女无套中出| 国产免国产免费| 精品国内自产拍在线播放观看 | 中文字幕av无码免费久久| 国产青榴视频在线观看| 日本一本二本三区免费 | 五月av综合av国产av| 少妇高潮无套内谢| 国产卡二卡三卡四卡免费网址| 日本丰满少妇bbb| 欧美大荫蒂毛茸茸视频| 女人18毛片水最多| 无遮挡午夜男女xx00动态| 亚洲精品国产一区二区在线观看| 麻豆妓女爽爽一区二区三| 乱人伦人妻中文字幕无码久久网| 亚洲精品国产熟女久久久| 高清av熟女一区| 欧美三级在线播放线观看| 日韩国产成人无码av毛片| 中国熟妇牲交视频免费| 中文字幕精品视频在线看免费 | 国产成人a区在线观看| 色欲天天天天天综合网| 一本大道东京热无码| 在线观看无码不卡av| 亚洲成色综合网站在线| 免费无码黄十八禁网站在线观看 | 亚洲精品乱码久久久久久久久久久久 | 国产男女猛烈无遮挡免费网站 | 特级a欧美做爰片第一次| 人妻巨大乳一二三区| 夜夜夜高潮夜夜爽夜夜爰爰| 亚洲性无码av在线| 夜夜爽妓女8888888视频| 亂倫近親相姦中文字幕|