Recombinant Human Proline-rich nuclear receptor coactivator 1 (PNRC1)

中文名稱：

人PNRC1重組蛋白
貨號(hào)：

CSB-YP018289HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人PNRC1重組蛋白
貨號(hào)：

CSB-EP018289HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人PNRC1重組蛋白
貨號(hào)：

CSB-EP018289HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PNRC1重組蛋白
貨號(hào)：

CSB-BP018289HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人PNRC1重組蛋白
貨號(hào)：

CSB-MP018289HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

PNRC1
Uniprot No.：

Q12796
別名：

PNRC1; PROL2; Proline-rich nuclear receptor coactivator 1; Proline-rich protein 2; Protein B4-2
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-327
氨基酸序列

MTVVSVPQRE PLVLGGRLAP LGFSSRGYFG ALPMVTTAPP PLPRIPDPRA LPPTLFLPHF LGGDGPCLTP QPRAPAALPN RSLAVAGGTP RAAPKKRRKK KVRASPAGQL PSRFHQYQQH RPSLEGGRSP ATGPSGAQEV PGPAAALAPS PAAAAGTEGA SPDLAPLRPA APGQTPLRKE VLKSKMGKSE KIALPHGQLV HGIHLYEQPK INRQKSKYNL PLTKITSAKR NENNFWQDSV SSDRIQKQEK KPFKNTENIK NSHLKKSAFL TEVSQKENYA GAKFSDPPSP SVLPKPPSHW MGSTVENSNQ NRELMAVHLK TLLKVQT
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Nuclear receptor coactivator. May play a role in signal transduction.
基因功能參考文獻(xiàn)：
1. PNRC and Grb2, by interacting with each other, can suppress nuclear receptor-mediated regulation and growth factor-mediated regulation in human breast tissue PMID: 15122321
2. Functional analysis of the 5' flanking region of the human PNRC gene by deletion mutagenesis, transient transfection and luciferase assays revealed that the -123/+27 region is the minimal promoter of the human PNRC gene. PMID: 18281297
3. Three human PNRC splicing variants designated PNRC1c, PNRC1d and PNRC1f, are identified. PMID: 18703122
4. RFX1 specifically bind to promoter region and negatively regulate the transcription of the human PNRC gene. PMID: 19334528
亞細(xì)胞定位：

Nucleus.
蛋白家族：

PNRC family, PNRC1 subfamily
組織特異性：

Expressed in liver, lung, fat and NK/T cells.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 17278

OMIM: 606714

KEGG: hsa:10957

STRING: 9606.ENSP00000336931

UniGene: Hs.75969