在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Pre-mRNA-splicing factor SPF27 (BCAS2)

In Stock
  • 中文名稱:
    Recombinant Human Pre-mRNA-splicing factor SPF27(BCAS2)
  • 貨號:
    CSB-EP002597HU
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    BCAS2
  • Uniprot No.:
  • 別名:
    bcas2; Breast carcinoma amplified sequence 2; Breast carcinoma-amplified sequence 2; DAM 1; DAM-1; DAM1; DNA amplified in mammary carcinoma 1 protein; MGC7712; Pre mRNA splicing factor SPF27; Pre-mRNA-splicing factor spf27; Snt309; SPF27; SPF27_HUMAN; Spliceosome associated protein amplified in breast cancer; Spliceosome associated protein SPF 27; Spliceosome-associated protein SPF 27
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    53.0kDa
  • 表達區域:
    1-225aa
  • 氨基酸序列
    MAGTGLVAGEVVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSAFETDIMRNEFERLAARQPIELLSMKRYELPAPSSGQKNDITAWQECVNNSMAQLEHQAVRIENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHIQDLNWQRKNMQLTAGSKLREMESNWVSLVSKNYEIERTIVQLENEIYQIKQQHGEANKENIRQDF
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal GST-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
  • 基因功能參考文獻:
    1. Study showed that CDK4 and BCAS2 may be target genes of miR-486 and levels of CDK4 and BCAS2 were both significantly higher in the esophageal cancer tissues and cell lines than levels in the normal tissues and cells. PMID: 29115564
    2. Chromosomal breakpoints involved the BCAS2 gene in 1q31 is associated with Diffuse Large B-Cell Lymphomas. PMID: 27356265
    3. BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination. PMID: 26319152
    4. These results demonstrate that Aurora B inhibits both direct interaction with the microtubule and oligomerization of the Dam1 complex to drive error correction during mitosis. PMID: 26560693
    5. BCAS2 is a novel androgen receptor-interacting protein. PMID: 25461807
    6. ERRbeta signalling leads to BCAS2-mediated blockage of the G1/S transition and inhibition of the epithelial to mesenchymal transition through FST-mediated regulation of E-cadherin PMID: 24667650
    7. The BCAS2 gene was amplified in two of 60 primary breast cancer tissues, but not in other cancer cells, providing the first evidence of amplification within this region and indicating that BCAS2 gene codes for a nuclear protein. PMID: 12169396
    8. This study suggested that BCAS2 might play an important role in breast cancer development by increasing the estrogen receptor's function. PMID: 15694360
    9. BCAS2 directly interacts with p53 to reduce p53 transcriptional activity by mildly but consistently decreasing p53 protein in the absence of DNA damage. In the presence of DNA damage, BCAS2 prominently reduces p53 protein. PMID: 19903847

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Nucleus, nucleolus.
  • 蛋白家族:
    SPF27 family
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 975

    OMIM: 605783

    KEGG: hsa:10286

    STRING: 9606.ENSP00000358554

    UniGene: Hs.22960



主站蜘蛛池模板: 成人免费午夜无码视频在线播放| 国产av无码久久精品| 亚洲第一网站男人都懂| 日本牲交大片无遮挡| 中文字幕人妻偷伦在线视频| 天天av天天翘天天综合网| 高h纯肉无码视频在线观看| 亚洲精品日本一区二区三区| 国产成人久久av免费看| 天堂资源最新在线| 暖暖 在线 日本 免费 中文| 午夜寂寞少妇aaa片毛片| 亚洲中文字幕乱码av波多ji| 欧美日韩国产专区一区二区| 男人用嘴添女人下身免费视频| 高清无码午夜福利视频| 国产高清卡1卡2卡3麻豆| 免费三级现频在线观看播放| 中国老熟女重囗味hdxx| 青青草国产成人99久久| 免费一本色道久久一区| 国产美女露脸口爆吞精| 大地资源中文在线观看官网第二页| 欧美亚洲国产精品久久高清| 亚洲色成人网站www永久蜜芽| 无码a∨高潮抽搐流白浆| 国产午夜福利视频在线观看| 日本强伦姧人妻一区二区| 人妻影音先锋啪啪av资源| 国产md视频一区二区三区| 脱了美女内裤猛烈进入gif| 精品久久久久中文字幕加勒比| 国产欧美在线亚洲一区| 久久无码字幕中文久久无码| 久久99精品国产99久久6尤物 | 天干天干天啪啪夜爽爽av| 亚洲熟女久久色| 欧美性大战xxxxx久久久√| 一本大道无码人妻精品专区| 久久99国产只有精品| 成人黄网站高清免费视频|