在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Potassium channel subfamily T member 1 (KCNT1), partial

Recombinant Human Potassium channel subfamily T member 1 (KCNT1), partial

  • 中文名稱：
    人KCNT1重組蛋白
  • 貨號：
    CSB-YP686387HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人KCNT1重組蛋白
  • 貨號：
    CSB-EP686387HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人KCNT1重組蛋白
  • 貨號：
    CSB-EP686387HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人KCNT1重組蛋白
  • 貨號：
    CSB-BP686387HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人KCNT1重組蛋白
  • 貨號：
    CSB-MP686387HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    KCNT1
  • Uniprot No.：
  • 別名：
    bA100C15.2; EIEE14; ENFL5; KCa4.1; KCNT1; KCNT1_HUMAN; Potassium channel subfamily T member 1; Potassium channel, sodium activated subfamily T, member 1; Potassium channel, subfamily T, member 1 ; Sequence like a calcium-activated K+ channel; SLACK ; Slo2.2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro).
  • 基因功能參考文獻：
    1. G288S missense mutation, associated with seizures and neurodevelopmental delay resulted in larger whole cell K+ currents compared with wild-type KCNT1 currents. PMID: 28747464
    2. Case report describing 3 infants with malignant migrating partial seizures with KCNT1 mutations accompanied by massive systemic to pulmonary collateral arteries. PMID: 28987752
    3. Stimulation of Slack K(+) channels alters mass at the plasma membrane by triggering dissociation of Phactr-1. PMID: 27545877
    4. In the present study, we evaluated two other potential mechanisms for stabilization of Slo2 channels in a closed state: (1) dewetting and collapse of the inner pore (hydrophobic gating) and (2) constriction of the inner pore by tight criss-crossing of the cytoplasmic ends of the S6 alpha-helical segments. PMID: 27682982
    5. two de novo, heterozygous KCNT1 mutations were identified in two unrelated malignant migrating partial seizures probands. Both mutations induced a marked leftward shift in homomeric channel activation gating. PMID: 26784557
    6. Better understanding of the mechanisms underlying KCNT1-related disease will produce further improvements in treatment of the associated severe seizure disorders. PMID: 26740507
    7. The sodium sensitivity of these epilepsy causing mutants probably determines the [Na(+)]i concentration at which these mutants exert their pathological effects. PMID: 26725113
    8. We demonstrate that KCNT1 mutations are highly pleiotropic and are associated with phenotypes other than nocturnal frontal lobe epilepsy and malignant migrating focal seizures of infancy. PMID: 26122718
    9. This study demonstrate that KCNT1 mutations are strongly associated with early-onset epileptic encephalopathy. PMID: 26140313
    10. Five de novo mutations were identified in four genes (SCNN1A, KCNJ16, KCNB2, and KCNT1) in three Brugada syndrome patients (20%) PMID: 25339316
    11. Nine different mutations of the KCNT1 (Slack) Na(+)-activated K(+) channel give rise to three distinct forms of epilepsy. PMID: 25482562
    12. Slick channels, in contrast to the similar Slack channels, are the only high-conductance K+ channels strongly sensitive to small changes in cell volume. PMID: 25347289
    13. Genetic studies reveal two novel genes for Ohtahara Syndrome: KCNT1 and PIGQ. PMID: 24463883
    14. Novel variations in KCNT1 do not allow prediction of functional phenotypes that might explain, at least in part, the symptoms of malignant migrating partial seizures of infancy (MMPSI). PMID: 24315024
    15. This gene-wide tagging study revealed no association between KCNT1 17 common variations and susceptibility of GGEs or AEDs (anti-epileptic drugs) efficacy of genetic generalized epilepsies in Chinese population. PMID: 24279416
    16. This study demonistrated that KCNT1 mutations implicated in epilepsy cause a marked increase in function PMID: 24591078
    17. this study performed analysis of KCNT1 in two unrelated patients with malignant migrating partial seizures in infancy.Because the G-to-A transition was located at CG dinucleotide sequences as previously reported for KCNT1 mutations, the recurrent occurrence of de novo KCNT1 mutations indicated the hot spots of these locations. PMID: 24029078
    18. Mutations in KCNT1 cause a severe form of ADNFLE and sporadic NFLE. PMID: 23086396
    19. Our data identify KCNT1 as a major disease-associated gene in Malignant migrating partial seizures of infancy . PMID: 23086397

    顯示更多

    收起更多

  • 相關疾病：
    Epileptic encephalopathy, early infantile, 14 (EIEE14); Epilepsy, nocturnal frontal lobe, 5 (ENFL5)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel family, Calcium-activated (TC 1.A.1.3) subfamily, KCa4.1/KCNT1 sub-subfamily
  • 組織特異性：
    Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle.
  • 數據庫鏈接：

    HGNC: 18865

    OMIM: 608167

    KEGG: hsa:57582

    STRING: 9606.ENSP00000360822

    UniGene: Hs.104950



主站蜘蛛池模板： 夫前人妻被灌醉侵犯在线| 日韩精品一区二区在线观看| 国产乱妇无乱码大黄aa片| 99视频精品国产免费观看| 夜夜嗨av一区二区三区| 牲欲强的熟妇农村老妇女视频| 亚洲色婷婷婷婷五月基地| h漫全彩纯肉无码网站| 国内精品久久久久久久小说| 色妞色视频一区二区三区四区| 国产精品一区二区av蜜芽| 高潮射精日本韩国在线播放| 无码人妻h动漫中文字幕| 国产超碰人人爽人人做| 一区三区不卡高清影视| 成人特级毛片www免费版| 性史性农村dvd毛片| 无遮挡aaaaa大片免费看| 中字幕视频在线永久在线| 国产末成年女av片一区二区| 久久天天躁夜夜躁狠狠85麻豆| 人人澡人摸人人添| 亚洲狠狠爱综合影院网页| 国产疯狂伦交大片| 国产 麻豆 日韩 欧美 久久| 97在线成人国产在线视频| 亚洲区激情区无码区日韩区| 久久综合精品国产二区无码| 无码人妻品一区二区三区精99| 成年女人午夜性视频| 狠狠躁18三区二区一区| 老妇肥熟凸凹丰满刺激| 久久婷婷人人澡人人爽人人喊| 亚洲欧美日韩综合俺去了| 亚洲日韩成人无码| 18禁无遮挡无码网站免费| 无线乱码一二三区免费看| 日本熟妇人妻xxxx| 亚洲不乱码卡一卡二卡4卡5卡| 性色av一二三天美传媒| 欧美丰满熟妇xxxx性ppx人交|