在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KCNT1 Antibody, Biotin conjugated

  • 中文名稱:
    KCNT1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA686387LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) KCNT1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KCNT1
  • 別名:
    bA100C15.2 antibody; EIEE14 antibody; ENFL5 antibody; KCa4.1 antibody; KCNT1 antibody; KCNT1_HUMAN antibody; Potassium channel subfamily T member 1 antibody; Potassium channel, sodium activated subfamily T, member 1 antibody; Potassium channel, subfamily T, member 1 antibody; Sequence like a calcium-activated K+ channel antibody; SLACK antibody; Slo2.2 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Potassium channel subfamily T member 1 protein (1026-1230AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro).
  • 基因功能參考文獻(xiàn):
    1. G288S missense mutation, associated with seizures and neurodevelopmental delay resulted in larger whole cell K+ currents compared with wild-type KCNT1 currents. PMID: 28747464
    2. Case report describing 3 infants with malignant migrating partial seizures with KCNT1 mutations accompanied by massive systemic to pulmonary collateral arteries. PMID: 28987752
    3. Stimulation of Slack K(+) channels alters mass at the plasma membrane by triggering dissociation of Phactr-1. PMID: 27545877
    4. In the present study, we evaluated two other potential mechanisms for stabilization of Slo2 channels in a closed state: (1) dewetting and collapse of the inner pore (hydrophobic gating) and (2) constriction of the inner pore by tight criss-crossing of the cytoplasmic ends of the S6 alpha-helical segments. PMID: 27682982
    5. two de novo, heterozygous KCNT1 mutations were identified in two unrelated malignant migrating partial seizures probands. Both mutations induced a marked leftward shift in homomeric channel activation gating. PMID: 26784557
    6. Better understanding of the mechanisms underlying KCNT1-related disease will produce further improvements in treatment of the associated severe seizure disorders. PMID: 26740507
    7. The sodium sensitivity of these epilepsy causing mutants probably determines the [Na(+)]i concentration at which these mutants exert their pathological effects. PMID: 26725113
    8. We demonstrate that KCNT1 mutations are highly pleiotropic and are associated with phenotypes other than nocturnal frontal lobe epilepsy and malignant migrating focal seizures of infancy. PMID: 26122718
    9. This study demonstrate that KCNT1 mutations are strongly associated with early-onset epileptic encephalopathy. PMID: 26140313
    10. Five de novo mutations were identified in four genes (SCNN1A, KCNJ16, KCNB2, and KCNT1) in three Brugada syndrome patients (20%) PMID: 25339316
    11. Nine different mutations of the KCNT1 (Slack) Na(+)-activated K(+) channel give rise to three distinct forms of epilepsy. PMID: 25482562
    12. Slick channels, in contrast to the similar Slack channels, are the only high-conductance K+ channels strongly sensitive to small changes in cell volume. PMID: 25347289
    13. Genetic studies reveal two novel genes for Ohtahara Syndrome: KCNT1 and PIGQ. PMID: 24463883
    14. Novel variations in KCNT1 do not allow prediction of functional phenotypes that might explain, at least in part, the symptoms of malignant migrating partial seizures of infancy (MMPSI). PMID: 24315024
    15. This gene-wide tagging study revealed no association between KCNT1 17 common variations and susceptibility of GGEs or AEDs (anti-epileptic drugs) efficacy of genetic generalized epilepsies in Chinese population. PMID: 24279416
    16. This study demonistrated that KCNT1 mutations implicated in epilepsy cause a marked increase in function PMID: 24591078
    17. this study performed analysis of KCNT1 in two unrelated patients with malignant migrating partial seizures in infancy.Because the G-to-A transition was located at CG dinucleotide sequences as previously reported for KCNT1 mutations, the recurrent occurrence of de novo KCNT1 mutations indicated the hot spots of these locations. PMID: 24029078
    18. Mutations in KCNT1 cause a severe form of ADNFLE and sporadic NFLE. PMID: 23086396
    19. Our data identify KCNT1 as a major disease-associated gene in Malignant migrating partial seizures of infancy . PMID: 23086397

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Epileptic encephalopathy, early infantile, 14 (EIEE14); Epilepsy, nocturnal frontal lobe, 5 (ENFL5)
  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Potassium channel family, Calcium-activated (TC 1.A.1.3) subfamily, KCa4.1/KCNT1 sub-subfamily
  • 組織特異性:
    Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18865

    OMIM: 608167

    KEGG: hsa:57582

    STRING: 9606.ENSP00000360822

    UniGene: Hs.104950



主站蜘蛛池模板: 成人欧美一区二区三区在线| 一二三四社区在线中文视频| 人妻丰满av无码久久不卡| 国产女主播喷水视频在线观看 | 成人影片麻豆国产影片免费观看| 国产jjzzjjzz视频全部免费| 欧美三級片黃色三級片黃色| 久久综合九色综合国产| 唐人社导航福利精品| 免费观看又污又黄在线观看| 精品亚洲成av人在线观看| 99热成人精品热久久6网站 | 精品久久久久久中文字幕202| 久久99精品国产麻豆宅宅| 精品国产综合区久久久久久| 97se狠狠狠狠狼鲁亚洲综合色 | 久久久国产精品亚洲一区| 中文人妻av久久人妻水密桃 | 亚洲综合av色婷婷| 亚洲精品tv久久久久久久久j | 狠狠色丁香久久婷婷综合_中| 无码人妻av一区二区三区波多野| 亚洲精品国产精品国自产观看| 色喜国模李晴超大尺度| 久久综合久久自在自线精品自| 男女做爰无遮挡性视频| 狠狠躁天天躁夜夜躁婷婷| 国产成a人亚洲精v品无码 | 国产波霸爆乳一区二区| 国产精品香蕉在线观看| 午夜无码一区二区三区在线| 国产精品久久久久久久久鸭| 国产精品sp调教打屁股| 久久久久久国产精品美女| 欲色欲色天天天www| 国产成人女人在线观看| av天堂永久资源网| 女人裸露免费视频无遮挡网站 | 欧美成人aaa片一区国产精品| 久久亚洲道色综合久久| 一边捏奶一边高潮视频|