在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Potassium channel subfamily K member 18 (KCNK18), partial

Recombinant Human Potassium channel subfamily K member 18 (KCNK18), partial

  • 中文名稱：
    人KCNK18重組蛋白
  • 貨號(hào)：
    CSB-YP801805HU1
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人KCNK18重組蛋白
  • 貨號(hào)：
    CSB-EP801805HU1
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人KCNK18重組蛋白
  • 貨號(hào)：
    CSB-EP801805HU1-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人KCNK18重組蛋白
  • 貨號(hào)：
    CSB-BP801805HU1
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人KCNK18重組蛋白
  • 貨號(hào)：
    CSB-MP801805HU1
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    KCNK18
  • Uniprot No.：
  • 別名：
    KCNK18; TRESK; TRIK; Potassium channel subfamily K member 18; TWIK-related individual potassium channel; TWIK-related spinal cord potassium channel
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation.
  • 基因功能參考文獻(xiàn)：
    1. The presence of SCN1A mutations and absence of mutations in ATP1A2 or CACNA1A suggest that the Polish patients represent FHM type 3. PMID: 26747084
    2. This study reveals new pharmacological modulators of K2P18.1 activity useful in dissecting native K2P18.1 function PMID: 24972239
    3. Our study shows the presence of several KCNK18 gene mutations in both migraine with aura and migraine without aura PMID: 25324165
    4. Migraine-associated TRESK mutation, but not the C110R variant, reduces the endogenous TRESK currents to a degree that affects trigeminal ganglion neuron excitability PMID: 24805079
    5. LQLP site is a fundamental determinant of the calcium-sensitivity of human TRESK. PMID: 25202008
    6. No association was observed for three polymorphisms in the KCNK18 gene with migraine phenotype or with any haplotypes. PMID: 23911303
    7. T cell lymphoblastic leukemias/lymphomas express TRESK protein. PMID: 23541583
    8. dominant-negative mutation of human TRESK was found to be linked to migraine with aura in a large pedigree. It is hoped that future TRESK agonists may prevent or ameliorate the debilitating symptoms of migraine. PMID: 22115960
    9. A frameshift mutation in the two-pore potassium channel protein TRESK is linked to migraine pathogenesis. (Review) PMID: 21855646
    10. a role for TRESK in the pathogenesis of typical migraine with aura. PMID: 20871611
    11. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    12. single residue of TRESK was found to be glycosylated upon heterologous expression. Signals of the N-glycosylation mutants were reduced by >50% because of inadequate surface expression of the channel. PMID: 20006580
    13. TRESK is a novel two-pore domain K+ channel that may set the resting membrane potential of cells in the spinal cord PMID: 12754259
    14. TRESK is activated by increased cytoplasmic calcium concentration, calcineurin being involved in the regulation; Serine 276 was identified as the major functional target of calcineurin in TRESK PMID: 14981085
    15. TRESK-2 is a functional member of the K(2P) channel family and contributes to the background K+ conductance in many types of cells [TRESK-2] PMID: 15123670
    16. Because 14-3-3 proteins are ubiquitous, they are expected to control the duration of calcineurin-mediated TRESK activation in all the cell types that express the channel, depending on the phosphorylation state of serine 264. PMID: 18397886
    17. background K+ currents expressed in Jurkat cells are mediated by TRESK channels PMID: 18506476
    18. Observational study of gene-disease association. (HuGE Navigator) PMID: 16385451

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Migraine with or without aura 13 (MGR13)
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Two pore domain potassium channel (TC 1.A.1.8) family
  • 組織特異性：
    Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 19439

    OMIM: 613655

    KEGG: hsa:338567

    STRING: 9606.ENSP00000334650

    UniGene: Hs.449650



主站蜘蛛池模板： 亚洲 欧美 激情 小说 另类| 国产精品51麻豆cm传媒| 国产日韩欧美| 丰满少妇女裸体bbw| 日韩精品无码一本二本三本| 中文字幕av伊人av无码av| 国产精品久免费的黄牛仔短裤| 中文字幕人妻被公上司喝醉506| 夜夜夜夜猛噜噜噜噜噜| 精品无码黑人又粗又大又长| 成人毛片一区二区| 99re6热视频这里只精品首页| 国产毛片一区二区精品| 99精品国产高清一区二区麻豆| 99国精品午夜福利视频不卡| 国产麻豆成人传媒免费观看| 欧美变态另类牲交zozo| 在线 偷窥 制服 另类| 天堂а√在线地址8中文种子| 欧美乱强伦xxxx孕妇| 无码人妻人妻经典| 久久久久久人妻无码| 亚洲 日韩 国产 中文有码| 337p日本大胆欧久久| 香蕉在线 亚洲 欧美 专区| 亚洲熟妇无码另类久久久| 日韩欧美人妻一区二区三区| 免费又黄又裸乳的视频| 满春阁精品a∨在线观看| 色屁屁www影院免费观看| 国产98在线 | 免费、| 蜜桃一区二区三区| 水蜜桃av无码一区二区| 国产高清女同学巨大乳在线观看| 午夜精品影视国产一区在线麻豆| 国语自产偷拍精品视频偷| 久久综合88熟人妻| 伊人久久大香线蕉av最新| 92国产精品午夜福利无毒不卡| 国产成人精品aa毛片| 免费观看又色又爽又黄的韩国|