Recombinant Human Polyadenylate-binding protein-interacting protein 2 (PAIP2)

中文名稱：

人PAIP2重組蛋白
貨號：

CSB-YP859027HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人PAIP2重組蛋白
貨號：

CSB-EP859027HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PAIP2重組蛋白
貨號：

CSB-BP859027HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人PAIP2重組蛋白
貨號：

CSB-MP859027HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

PAIP2
Uniprot No.：

Q9BPZ3
別名：

PABP-interacting protein 2; PAIP-2; PAIP2; PAIP2_HUMAN; poly(A) binding protein interacting protein 2; Poly(A)-binding protein-interacting protein 2; Polyadenylate-binding protein-interacting protein 2
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區(qū)域：

1-127
氨基酸序列

MKDPSRSSTS PSIINEDVII NGHSHEDDNP FAEYMWMENE EEFNRQIEEE LWEEEFIERC FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNDLVISDGS SLEDLVVKSN LNPNAKEFVP GVKYGNI
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.
基因功能參考文獻：
1. Paip2 is a host antiviral restriction factor antagonized by PABP accumulation in HCMV-infected cells PMID: 23964095
2. Role of PAIP2 in modulation of GLUT5 mRNA stability. PMID: 12820898
3. PAIP2 is a crucial regulator of VEGF mRNA and has a role in regulating angiogenesis PMID: 15175342
4. The turnover of Paip2 in the cell is mediated by EDD and is regulated by PABP. PMID: 16601676
亞細胞定位：

Cytoplasm.
蛋白家族：

PAIP2 family
組織特異性：

Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid.
數(shù)據(jù)庫鏈接：

HGNC: 17970

OMIM: 605604

KEGG: hsa:51247

STRING: 9606.ENSP00000265192

UniGene: Hs.396644