在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Polyadenylate-binding protein-interacting protein 1 (PAIP1)

  • 中文名稱:
    人PAIP1重組蛋白
  • 貨號:
    CSB-YP880930HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人PAIP1重組蛋白
  • 貨號:
    CSB-EP880930HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人PAIP1重組蛋白
  • 貨號:
    CSB-BP880930HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人PAIP1重組蛋白
  • 貨號:
    CSB-MP880930HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    PAIP1
  • Uniprot No.:
  • 別名:
    MGC12360; OTTHUMP00000221601; OTTMUSP00000026880; PABC1 interacting protein 1; PABP interacting protein 1; PABP-interacting protein 1; PAIP 1 ; PAIP-1; Paip1; PAIP1_HUMAN; Poly(A) binding protein interacting protein 1; Poly(A)-binding protein-interacting protein 1; Polyadenylate binding protein interacting protein 1; Polyadenylate-binding protein-interacting protein 1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-479
  • 氨基酸序列
    MSDGFDRAPG AGRGRSRGLG RGGGGPEGGG FPNGAGPAER ARHQPPQPKA PGFLQPPPLR QPRTTPPPGA QCEVPASPQR PSRPGALPEQ TRPLRAPPSS QDKIPQQNSE SAMAKPQVVV APVLMSKLSV NAPEFYPSGY SSSYTESYED GCEDYPTLSE YVQDFLNHLT EQPGSFETEI EQFAETLNGC VTTDDALQEL VELIYQQATS IPNFSYMGAR LCNYLSHHLT ISPQSGNFRQ LLLQRCRTEY EVKDQAAKGD EVTRKRFHAF VLFLGELYLN LEIKGTNGQV TRADILQVGL RELLNALFSN PMDDNLICAV KLLKLTGSVL EDAWKEKGKM DMEEIIQRIE NVVLDANCSR DVKQMLLKLV ELRSSNWGRV HATSTYREAT PENDPNYFMN EPTFYTSDGV PFTAADPDYQ EKYQELLERE DFFPDYEENG TDLSGAGDPY LDDIDDEMDP EIEEAYEKFC LESERKRKQ
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.; (Microbial infection) Upon interaction with SARS coronavirus SARS-CoV NSP3 protein, plays an important role in viral protein synthesis.
  • 基因功能參考文獻:
    1. Results showed that mRNA and protein expression of PAIP1, a miRNA-340 target gene, were down-regulated in women with gestational diabetes. PMID: 29358694
    2. Data provide evidence that the stability of Paip1 can be regulated by ubiquitin-mediated degradation, thus highlighting the importance of WWP2 as a suppressor of translation. PMID: 25266661
    3. The Paip1-eIF3 interaction is impaired by the mTORC1 inhibitors. PMID: 24396066
    4. the crystal structure of the middle domain of Paip1 isoform 2 (Paip1M) as determined by single-wavelength anomalous dispersion phasing is reported. PMID: 21539810
    5. Paip1 is translational activator in 5' cap-dependent translation by interacting with PABP & initiation factors eIF4A & eIF3. Crystallization & preliminary diffraction analysis of middle domain of Paip1 gives crystals that diffract to resolution of 2.2 A. PMID: 19851022
    6. Paip1 interacts with poly(A) binding protein through two independent binding motifs. PMID: 11997512
    7. eIF3-Paip1 stabilizes the interaction between PABP and eIF4G, which brings about the circularization of the mRNA. PMID: 18725400

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 16945

    OMIM: 605184

    KEGG: hsa:10605

    STRING: 9606.ENSP00000302768

    UniGene: Hs.482038



主站蜘蛛池模板: 中文字幕无码人妻aaa片| 亚洲裸男gv网站| 人人妻人人澡人人爽欧美二区| 97影院理论片手机在线观看| 一本一本久久a久久综合精品蜜桃| 国内少妇偷人精品视频| 国产三级精品三级| 五级黄高潮片90分钟视频| 强迫大乳人妻中文字幕| 国自产拍偷拍精品啪啪av| 性按摩玩人妻hd中文字幕| 国产av综合影院| 欧美制服丝袜人妻另类| 久久天天躁狠狠躁夜夜2019| 国产一区二区三区小说| 人妻无码中文字幕| 激情97综合亚洲色婷婷五| 久久精品女人天堂av免费观看| 国产精品9999久久久久仙踪林| 在线亚洲高清揄拍自拍一品区 | 日韩精品乱码av一区二区| 西西人体大胆无码视频| 国产99久久久欧美黑人刘玥| 亚洲欧洲日产国码无码av一| 国内精品视频自在一区| 奇米影视色777四色在线首页| 大黑人交xxxx18视频| 国产精品久久久久久妇女| 国产卡二卡三卡四卡免费网址| 中日产幕无线码一区| 精品国产一区二区三区av 性色| 婷婷色香合缴缴情av第三区 | 少妇把腿扒开让我舔18| 丰满少妇高潮惨叫久久久一| 中文资源在线天堂库8| 夜夜高潮夜夜爽夜夜爱| 在线观看的网站| 成 人 网 站94免费观看| 欧美丰满熟妇bbb久久久| 亚洲精品久久区二区三区蜜桃臀| 午夜三级a三级三点|