在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Polyadenylate-binding protein-interacting protein 1 (PAIP1)

  • 中文名稱:
    人PAIP1重組蛋白
  • 貨號:
    CSB-YP880930HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人PAIP1重組蛋白
  • 貨號:
    CSB-EP880930HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人PAIP1重組蛋白
  • 貨號:
    CSB-BP880930HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人PAIP1重組蛋白
  • 貨號:
    CSB-MP880930HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    PAIP1
  • Uniprot No.:
  • 別名:
    MGC12360; OTTHUMP00000221601; OTTMUSP00000026880; PABC1 interacting protein 1; PABP interacting protein 1; PABP-interacting protein 1; PAIP 1 ; PAIP-1; Paip1; PAIP1_HUMAN; Poly(A) binding protein interacting protein 1; Poly(A)-binding protein-interacting protein 1; Polyadenylate binding protein interacting protein 1; Polyadenylate-binding protein-interacting protein 1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-479
  • 氨基酸序列
    MSDGFDRAPG AGRGRSRGLG RGGGGPEGGG FPNGAGPAER ARHQPPQPKA PGFLQPPPLR QPRTTPPPGA QCEVPASPQR PSRPGALPEQ TRPLRAPPSS QDKIPQQNSE SAMAKPQVVV APVLMSKLSV NAPEFYPSGY SSSYTESYED GCEDYPTLSE YVQDFLNHLT EQPGSFETEI EQFAETLNGC VTTDDALQEL VELIYQQATS IPNFSYMGAR LCNYLSHHLT ISPQSGNFRQ LLLQRCRTEY EVKDQAAKGD EVTRKRFHAF VLFLGELYLN LEIKGTNGQV TRADILQVGL RELLNALFSN PMDDNLICAV KLLKLTGSVL EDAWKEKGKM DMEEIIQRIE NVVLDANCSR DVKQMLLKLV ELRSSNWGRV HATSTYREAT PENDPNYFMN EPTFYTSDGV PFTAADPDYQ EKYQELLERE DFFPDYEENG TDLSGAGDPY LDDIDDEMDP EIEEAYEKFC LESERKRKQ
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.; (Microbial infection) Upon interaction with SARS coronavirus SARS-CoV NSP3 protein, plays an important role in viral protein synthesis.
  • 基因功能參考文獻:
    1. Results showed that mRNA and protein expression of PAIP1, a miRNA-340 target gene, were down-regulated in women with gestational diabetes. PMID: 29358694
    2. Data provide evidence that the stability of Paip1 can be regulated by ubiquitin-mediated degradation, thus highlighting the importance of WWP2 as a suppressor of translation. PMID: 25266661
    3. The Paip1-eIF3 interaction is impaired by the mTORC1 inhibitors. PMID: 24396066
    4. the crystal structure of the middle domain of Paip1 isoform 2 (Paip1M) as determined by single-wavelength anomalous dispersion phasing is reported. PMID: 21539810
    5. Paip1 is translational activator in 5' cap-dependent translation by interacting with PABP & initiation factors eIF4A & eIF3. Crystallization & preliminary diffraction analysis of middle domain of Paip1 gives crystals that diffract to resolution of 2.2 A. PMID: 19851022
    6. Paip1 interacts with poly(A) binding protein through two independent binding motifs. PMID: 11997512
    7. eIF3-Paip1 stabilizes the interaction between PABP and eIF4G, which brings about the circularization of the mRNA. PMID: 18725400

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 16945

    OMIM: 605184

    KEGG: hsa:10605

    STRING: 9606.ENSP00000302768

    UniGene: Hs.482038



主站蜘蛛池模板: 亚洲熟妇无码av不卡在线播放| 蜜乳av久久久久久久久久久| 麻豆国产成人av在线播放欲色| 三级男人添奶爽爽爽视频| 亚洲老熟女性亚洲| 国产人妻人伦精品1国产丝袜| 中文在线а√在线天堂中文| 亚洲精品午夜理伦不卡在线观看| 国产在线观看无码免费视频| 伊人情人综合网| 日产无码中文字幕av| 国产日韩综合av在线观看一区| 免费网站观看www在线观看| 无码熟妇人妻av在线影片| 亚洲中文字幕永久在线不卡| 国产精品亚洲二区在线看| 亚洲自偷精品视频自拍| 无码人妻精品一区二区三区东京热| 国产av中文av无码av狼人| 800av凹凸视频在线观看| 性生交大片免费看女人按摩| 在线日韩日本国产亚洲| 黄网站免费永久在线观看下载| 久久久一本精品99久久精品88| 亚洲国产欧美国产综合一区| 久久影院九九被窝爽爽| 97熟女毛毛多熟妇人妻aⅴ| 亚洲 欧美 变态 另类 综合| 中文字幕人妻熟女人妻洋洋| 国产精品三级av及在线观看| 精品无码成人片一区二区98| 岛国av无码免费无禁网站 | 国产一区二区三区精品av| 国产人成无码视频在线1000| 国产午夜精品一区理论片飘花 | 久久青青草原精品国产app| 国产大陆亚洲精品国产| 国产在视频线精品视频| 中文字日产乱码免费1~3软件| 色婷婷五月综合色啪网| 久久综合伊人77777|