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  4. PAIP1 Antibody

PAIP1 Antibody

  • 中文名稱：
    PAIP1兔多克隆抗體
  • 貨號：
    CSB-PA880930ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: PAIP1 antibody at 8μg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: PC-3 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 54, 46, 43 kDa
      Observed band size: 54 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PAIP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PAIP1
  • 別名：
    MGC12360 antibody; OTTHUMP00000221601 antibody; OTTMUSP00000026880 antibody; PABC1 interacting protein 1 antibody; PABP interacting protein 1 antibody; PABP-interacting protein 1 antibody; PAIP 1 antibody; PAIP-1 antibody; Paip1 antibody; PAIP1_HUMAN antibody; Poly(A) binding protein interacting protein 1 antibody; Poly(A)-binding protein-interacting protein 1 antibody; Polyadenylate binding protein interacting protein 1 antibody; Polyadenylate-binding protein-interacting protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Polyadenylate-binding protein-interacting protein 1 protein (1-260AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:200-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.; (Microbial infection) Upon interaction with SARS coronavirus SARS-CoV NSP3 protein, plays an important role in viral protein synthesis.
  • 基因功能參考文獻：
    1. Results showed that mRNA and protein expression of PAIP1, a miRNA-340 target gene, were down-regulated in women with gestational diabetes. PMID: 29358694
    2. Data provide evidence that the stability of Paip1 can be regulated by ubiquitin-mediated degradation, thus highlighting the importance of WWP2 as a suppressor of translation. PMID: 25266661
    3. The Paip1-eIF3 interaction is impaired by the mTORC1 inhibitors. PMID: 24396066
    4. the crystal structure of the middle domain of Paip1 isoform 2 (Paip1M) as determined by single-wavelength anomalous dispersion phasing is reported. PMID: 21539810
    5. Paip1 is translational activator in 5' cap-dependent translation by interacting with PABP & initiation factors eIF4A & eIF3. Crystallization & preliminary diffraction analysis of middle domain of Paip1 gives crystals that diffract to resolution of 2.2 A. PMID: 19851022
    6. Paip1 interacts with poly(A) binding protein through two independent binding motifs. PMID: 11997512
    7. eIF3-Paip1 stabilizes the interaction between PABP and eIF4G, which brings about the circularization of the mRNA. PMID: 18725400

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  • 亞細胞定位：
    Cytoplasm.
  • 數據庫鏈接：

    HGNC: 16945

    OMIM: 605184

    KEGG: hsa:10605

    STRING: 9606.ENSP00000302768

    UniGene: Hs.482038



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