在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Pleckstrin homology domain-containing family M member 1 (PLEKHM1), partial

Recombinant Human Pleckstrin homology domain-containing family M member 1 (PLEKHM1), partial

  • 中文名稱：
    人PLEKHM1重組蛋白
  • 貨號(hào)：
    CSB-YP896516HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PLEKHM1重組蛋白
  • 貨號(hào)：
    CSB-EP896516HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PLEKHM1重組蛋白
  • 貨號(hào)：
    CSB-EP896516HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PLEKHM1重組蛋白
  • 貨號(hào)：
    CSB-BP896516HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PLEKHM1重組蛋白
  • 貨號(hào)：
    CSB-MP896516HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PLEKHM1
  • Uniprot No.：
  • 別名：
    162 kDa adapter protein; AP162; PH domain-containing family M member 1; PKHM1_HUMAN; Pleckstrin homology domain-containing family M member 1; PLEKHM1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7. May have a role in sialyl-lex-mediated transduction of apoptotic signals. Involved in bone resorption.; (Microbial infection) In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7.
  • 基因功能參考文獻(xiàn)：
    1. identified PLEKHM1 as an endolysosomal adaptor platform that acts as a central hub to integrate endocytic and autophagic pathways at the lysosome PMID: 25905573
    2. Authors show that Pleckstrin homology domain-containing protein family member 1 (PLEKHM1), a lysosomal adaptor, is targeted by Salmonella through direct interaction with SifA. PMID: 25500191
    3. PLEKHM1 regulates autophagosome-lysosome fusion through homotypic fusion and protein sorting complex and LC3/GABARAP proteins. PMID: 25498145
    4. These data indicate that B2 is a novel, ubiquitously expressed protein with a putative adapter function. The protein has been named AP162. PMID: 12820725
    5. PLEKHM1 is a novel gene implicated in the development of osteopetrosis, with a putative critical function in vesicular transport in the osteoclast. PMID: 17404618
    6. heterozygous mutation (R714C) of the osteopetrosis gene, pleckstrin homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP secretion in osteoclasts PMID: 17997709

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Osteopetrosis, autosomal recessive 6 (OPTB6)
  • 亞細(xì)胞定位：
    Autolysosome membrane. Endosome membrane. Late endosome membrane. Lysosome membrane.
  • 組織特異性：
    Expressed in placenta, liver, prostate, thymus, spleen, ovary, colon, colon carcinoma and peripheral blood lymphocytes (PBL). Weakly expressed in brain, lung, kidney, and testis. No expression in heart, skeletal muscle, pancreas and small intestine. Predo
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29017

    OMIM: 611466

    KEGG: hsa:9842

    STRING: 9606.ENSP00000389913

    UniGene: Hs.514242



主站蜘蛛池模板： 亚洲一区二区三区| 香蕉97超级碰碰碰免费公开| 挺进邻居丰满少妇的身体| 久久国产欧美成人网站| 天天躁日日躁aaaaxxxx| 色噜噜狠狠一区二区三区| 国产精品福利视频萌白酱| 99精品久久久久中文字幕| 奇米777四色影视在线看| 18禁美女裸体免费网站| 国产欧美va欧美va香蕉在线观看| 亚洲va在线va天堂va欧美va| 亚洲线精品一区二区三区影音先锋| 少妇熟女高潮流白浆| 青青青国产免a在线观看| 国产日韩精品视频无码| 日本在线视频www鲁啊鲁| 亚洲第一se情网站| 亚洲国产成人久久综合电影| 99大香伊乱码一区二区| 国产成人一区二区三区| 亚洲精品喷潮一区二区三区| 天堂资源中文最新版在线一区| 欧美极品色午夜在线视频| 丰满少妇人妻无码专区| 国产精品无码成人午夜电影| 欧美精品九九久久久久久久久| 亚洲精品久久午夜麻豆| 国产熟女一区二区三区五月婷| 精品一区二区三区在线观看视频| 永久免费男同av无码入口| 成人爽a毛片在线视频| 97久久超碰亚洲视觉盛宴| 亚洲精品无码av黄瓜影视| 九九久久精品国产免费看小说| 欧美精品一区二区蜜臀亚洲| 久久久免费精品re6| 国内一区二区三区香蕉aⅴ| 精品无码成人片一区二区98| 无尺码精品产品日韩| 国产精品乱子伦xxxx裸|