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  4. Recombinant Human Platelet endothelial aggregation receptor 1 (PEAR1), partial

Recombinant Human Platelet endothelial aggregation receptor 1 (PEAR1), partial

  • 中文名稱：
    人PEAR1重組蛋白
  • 貨號：
    CSB-YP017765HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PEAR1重組蛋白
  • 貨號：
    CSB-EP017765HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PEAR1重組蛋白
  • 貨號：
    CSB-EP017765HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PEAR1重組蛋白
  • 貨號：
    CSB-BP017765HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PEAR1重組蛋白
  • 貨號：
    CSB-MP017765HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    hPEAR1; JEDI; MEGF12; Multiple EGF-like domains protein 12; Multiple epidermal growth factor-like domains protein 12; Pear1; PEAR1_HUMAN; Platelet endothelial aggregation receptor 1; RP11-107D16.3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.
  • 基因功能參考文獻：
    1. PEAR1 rs56260937 minor allele was an independent predictor of revascularization events. PMID: 29212986
    2. For Chinese patients with ACS treated with aspirin and clopidogrel, genetic mutations in rs822441/rs822442 in PEAR1 correlated significantly with platelet activity after adjusting for CYP2C19 *2/*3 alleles. PMID: 29407631
    3. PEAR1 methylation corresponded to variability in expression of ISGL20L2, RRNAD1, MRLP24, HDGF and PRCC. PMID: 29614055
    4. PEAR1 rs12041331 polymorphism may influence ticagrelor pharmacodynamics PMID: 27937053
    5. DNA methylation at 4 different loci of PEAR1 during in vitro megakaryopoiesis, was studied. PMID: 27313330
    6. In a White population, we could not replicate previous reports from experimental studies or obtained in patients suggesting that PEAR1 might be a susceptibility gene for cardiovascular complications PMID: 28449647
    7. PEAR1 genetic variations were strongly associated with platelet reactivity in a Chinese patient population with coronary heart disease undergoing dual antiplatelet therapy with aspirin and clopidogrel. PMID: 26962983
    8. A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 C3435T, TBXA2R (rs1131882), and PLA2G7 (rs1051931-rs7756935) polymorphisms. PMID: 27641736
    9. in a Chinese pedigree, SNP rs778026543, but not rs1952294 and rs822442, may be a susceptibility for pulmonary thromboembolism PMID: 28002340
    10. Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis. PMID: 26156496
    11. Results suggest that genetic variation of PEAR1 is a significant determinant of endothelial function through pathways implicated in cardiovascular disease. PMID: 26406321
    12. FcepsilonRI alpha-chain is an activating platelet endothelium aggregation receptor 1 (PEAR1) ligand. PMID: 25713122
    13. genetic variability of GAS6 and PEAR1 genes may be associated with platelet hyperaggregability PMID: 25703520
    14. A common genetic variant in PEAR1 (rs12041331) reproducibly influenced platelet aggregation in aspirin-treated patients with coronary artery disease. PMID: 25360888
    15. study suggests that PEAR1 is not a hypertension susceptibility gene in humans. PMID: 25541647
    16. The SNPs in two regions of the PEAR1 gene, from rs3737224 to rs822442, and from rs1214331 to rs12566888, probably play important roles in prasugrel pharmacodynamics PMID: 23859572
    17. additional exonic variants in PEAR1 that may also determine variability in platelet aggregation, were identified. PMID: 23704978
    18. A-allele carriers of rs12041331 in the platelet endothelial aggregation receptor-1 (PEAR1) gene were more likely to experience a cardiovascular event or death compared with GG homozygotes PMID: 23392654
    19. PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway. PMID: 23667054
    20. A specific intronic PEAR1 gene variant is ientified that associated with greater platelet aggregability and protein expression. PMID: 21791418
    21. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20526338
    22. PEAR1 is a novel platelet receptor that signals secondary to alpha(IIb)beta(3)-mediated platelet-platelet contacts PMID: 15851471
    23. C allele of PEAR1 (Platelet endothelial aggregation receptor-1)was generally associated in both ethnic groups with increased aggregation of native platelets PMID: 18511696
    24. Observational study of gene-disease association. (HuGE Navigator) PMID: 19429868
    25. Observational study of gene-disease association. (HuGE Navigator) PMID: 18511696

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  • 亞細胞定位：
    Cell membrane; Single-pass membrane protein.
  • 蛋白家族：
    MEGF family
  • 組織特異性：
    Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord
  • 數據庫鏈接：

    HGNC: 33631

    OMIM: 610278

    KEGG: hsa:375033

    STRING: 9606.ENSP00000292357

    UniGene: Hs.142003



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