在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PEAR1 Antibody, Biotin conjugated

  • 中文名稱:
    PEAR1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA017765LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PEAR1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    hPEAR1 antibody; JEDI antibody; MEGF12 antibody; Multiple EGF-like domains protein 12 antibody; Multiple epidermal growth factor-like domains protein 12 antibody; Pear1 antibody; PEAR1_HUMAN antibody; Platelet endothelial aggregation receptor 1 antibody; RP11-107D16.3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Platelet endothelial aggregation receptor 1 protein (932-1037AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.
  • 基因功能參考文獻:
    1. PEAR1 rs56260937 minor allele was an independent predictor of revascularization events. PMID: 29212986
    2. For Chinese patients with ACS treated with aspirin and clopidogrel, genetic mutations in rs822441/rs822442 in PEAR1 correlated significantly with platelet activity after adjusting for CYP2C19 *2/*3 alleles. PMID: 29407631
    3. PEAR1 methylation corresponded to variability in expression of ISGL20L2, RRNAD1, MRLP24, HDGF and PRCC. PMID: 29614055
    4. PEAR1 rs12041331 polymorphism may influence ticagrelor pharmacodynamics PMID: 27937053
    5. DNA methylation at 4 different loci of PEAR1 during in vitro megakaryopoiesis, was studied. PMID: 27313330
    6. In a White population, we could not replicate previous reports from experimental studies or obtained in patients suggesting that PEAR1 might be a susceptibility gene for cardiovascular complications PMID: 28449647
    7. PEAR1 genetic variations were strongly associated with platelet reactivity in a Chinese patient population with coronary heart disease undergoing dual antiplatelet therapy with aspirin and clopidogrel. PMID: 26962983
    8. A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 C3435T, TBXA2R (rs1131882), and PLA2G7 (rs1051931-rs7756935) polymorphisms. PMID: 27641736
    9. in a Chinese pedigree, SNP rs778026543, but not rs1952294 and rs822442, may be a susceptibility for pulmonary thromboembolism PMID: 28002340
    10. Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis. PMID: 26156496
    11. Results suggest that genetic variation of PEAR1 is a significant determinant of endothelial function through pathways implicated in cardiovascular disease. PMID: 26406321
    12. FcepsilonRI alpha-chain is an activating platelet endothelium aggregation receptor 1 (PEAR1) ligand. PMID: 25713122
    13. genetic variability of GAS6 and PEAR1 genes may be associated with platelet hyperaggregability PMID: 25703520
    14. A common genetic variant in PEAR1 (rs12041331) reproducibly influenced platelet aggregation in aspirin-treated patients with coronary artery disease. PMID: 25360888
    15. study suggests that PEAR1 is not a hypertension susceptibility gene in humans. PMID: 25541647
    16. The SNPs in two regions of the PEAR1 gene, from rs3737224 to rs822442, and from rs1214331 to rs12566888, probably play important roles in prasugrel pharmacodynamics PMID: 23859572
    17. additional exonic variants in PEAR1 that may also determine variability in platelet aggregation, were identified. PMID: 23704978
    18. A-allele carriers of rs12041331 in the platelet endothelial aggregation receptor-1 (PEAR1) gene were more likely to experience a cardiovascular event or death compared with GG homozygotes PMID: 23392654
    19. PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway. PMID: 23667054
    20. A specific intronic PEAR1 gene variant is ientified that associated with greater platelet aggregability and protein expression. PMID: 21791418
    21. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20526338
    22. PEAR1 is a novel platelet receptor that signals secondary to alpha(IIb)beta(3)-mediated platelet-platelet contacts PMID: 15851471
    23. C allele of PEAR1 (Platelet endothelial aggregation receptor-1)was generally associated in both ethnic groups with increased aggregation of native platelets PMID: 18511696
    24. Observational study of gene-disease association. (HuGE Navigator) PMID: 19429868
    25. Observational study of gene-disease association. (HuGE Navigator) PMID: 18511696

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass membrane protein.
  • 蛋白家族:
    MEGF family
  • 組織特異性:
    Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord
  • 數據庫鏈接:

    HGNC: 33631

    OMIM: 610278

    KEGG: hsa:375033

    STRING: 9606.ENSP00000292357

    UniGene: Hs.142003



主站蜘蛛池模板: 亚洲精品伦理熟女国产一区二区| 丁香激情综合久久伊人久久| 午夜精品久久久久久久| 色偷偷88888欧美精品久久久| 国产蝌蚪视频一区二区三区| 一区二区视频传媒有限公司| 国产精品亚洲a∨天堂| 性欧美丰满熟妇xxxx性仙踪林| 国产精品自在在线午夜出白浆| 国语做受对白xxxxx在线| 99久久国产亚洲高清观看 | 亚洲一区二区三区高清av| 国内揄拍国内精品对白86| 蜜臀av色欲a片无人一区| 国产成人三级在线视频网站观看 | 免费无码av一区二区三区| 99久久精品无码一区二区三区| 毛茸茸性xxxx毛茸茸毛茸茸| 最新国产aⅴ精品无码| 欧美va久久久噜噜噜久久| 西西人体大胆午夜视频| 强睡邻居人妻中文字幕| 四虎一区二区成人免费影院网址 | 97久久超碰国产精品2021| 久久九九精品99国产精品| 欧美孕妇xxxx做受欧美88| 撕开奶罩揉吮奶头视频| 又大又黄又粗又爽的免费视频| 欧美级特黄aaaaaa片| 国产av一二三无码影片| 奇米影视7777久久精品| 人妻少妇偷人精品无码| 夜夜精品无码一区二区三区| 中国xxx农村性视频| 欧美 日韩 国产 成人 在线观看| 波多野结衣在线播放| 久久久久蜜桃精品成人片| 免费又黄又爽又猛的毛片| 成人网站在线进入爽爽爽| 国产男女免费完整视频| 日本理论片午午伦夜理片2021|